DNA repair after oxidative stress: current challenges.
TLDR
This data indicates that chronic oxidative stress can induce protective pathways lowering genotoxicity, and mitochondria lack nucleotide excision repair, which is critical for the understanding of a wide range of human disorders.About:
This article is published in Current Opinion in Toxicology.The article was published on 2018-02-01 and is currently open access. It has received 65 citations till now. The article focuses on the topics: Nucleotide excision repair & DNA repair.read more
Citations
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Targeted and Persistent 8-Oxoguanine Base Damage at Telomeres Promotes Telomere Loss and Crisis
Elise Fouquerel,Ryan P. Barnes,Shikhar Uttam,Simon C. Watkins,Marcel P. Bruchez,Patricia L. Opresko,Patricia L. Opresko +6 more
TL;DR: It is shown that telomeric 8-oxoG accumulation directly drives telomere crisis, leading to chromatin bridges and micronucleus formation upon cell division by confining base damage to the telomeres.
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Beneficial and Detrimental Effects of Reactive Oxygen Species on Lifespan: A Comprehensive Review of Comparative and Experimental Studies.
TL;DR: The relationship between ROS and lifespan is complex as mentioned in this paper, and it can have both beneficial or detrimental effects on longevity depending on the species and conditions of the ROS and the ROS levels.
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Cisplatin-Induced Ototoxicity: Updates on Molecular Targets.
TL;DR: This review looks at the molecular targets of cisplatin, and the intracellular pathways underlying its ototoxicity, and special attention is devoted to signal transduction processes involving cis platin that may promote the development of new strategies to prevent cisplin-induced hearing loss.
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Interplay of Guanine Oxidation and G-Quadruplex Folding in Gene Promoters.
TL;DR: The mechanisms described drive induction of stress response, DNA repair, or estrogen-induced genes, and these pathways are novel potential anticancer targets for therapeutic intervention.
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The role of curcumin in aging and senescence: Molecular mechanisms.
TL;DR: Curcumin, a polyphenolic compound isolated from the Curcuma longa, has been shown to exert anti-aging characteristics as discussed by the authors, such as antioxidative, anti-inflammatory, anticancer, chemopreventive, and anti-neurodegenerative characteristics.
References
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Superoxide Dismutase AN ENZYMIC FUNCTION FOR ERYTHROCUPREIN (HEMOCUPREIN)
Joe M. McCord,Irwin Fridovich +1 more
TL;DR: The demonstration that O2·- can reduce ferricytochrome c and tetranitromethane, and that superoxide dismutase, by competing for the superoxide radicals, can markedly inhibit these reactions, is demonstrated.
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Signal transduction by reactive oxygen species
TL;DR: Emerging evidence suggests that ROS regulate diverse physiological parameters ranging from the response to growth factor stimulation to the generation of the inflammatory response, and that dysregulated ROS signaling may contribute to a host of human diseases.
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Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress
TL;DR: Results indicate that mitochondrial DNA is a critical cellular target for ROS, and persistent mitochondrial DNA damage may serve as a useful biomarker for ROS-associated diseases.
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Adaptive Response of Human Lymphocytes to Low Concentrations of Radioactive Thymidine
TL;DR: When human lymphocytes were cultured with [3H]thymidine, which acts as a source of low-level chronic radiation, and then exposed to 150 rad of x-rays at 5, 7, 9, or 11 hours before fixation, the yield of chromatid aberrations was less than the sum of the yields of aberration induced by [3 H]thcyidine and x-ray separately.
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Free radicals and antioxidants: updating a personal view.
TL;DR: This article looks back to the antioxidant/free radical field in 1994 and discusses how it has progressed in the past 18 years and suggests that increasing endogenous antioxidant levels (e.g., by supplying "pro-oxidants") may be a better approach to therapeutics and disease prevention than consuming large doses of "dietary antioxidants."
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