Does mRNA SARS-CoV-2 vaccine detrimentally affect male fertility, as reflected by semen analysis?
Dror Lifshitz,Dror Lifshitz,Dror Lifshitz,Jigal Haas,Jigal Haas,Oshrit Lebovitz,Oshrit Lebovitz,Gil Raviv,Gil Raviv,Raoul Orvieto,Raoul Orvieto,Adva Aizer,Adva Aizer +12 more
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TLDR
In this paper, a prospective cohort study was conducted at a single large tertiary centre in Israel between February and March of 2021, where semen samples from 75 fertile men were analyzed 1-2 months following their second dose of Pfizer's COVID-19 vaccine.Abstract:
Research question Does Pfizer's coronavirus disease 2019 (COVID-19) vaccination detrimentally affect semen analysis parameters? Design A prospective cohort study was conducted at a single large tertiary centre in Israel between February and March of 2021. Semen samples from 75 fertile men were analysed 1–2 months following their second dose of Pfizer's COVID-19 vaccine. The semen parameters were compared with the World Health Organization (WHO) reference ranges. The primary outcome was the percentage of abnormal semen parameters in those who were vaccinated, i.e. the rates of oligozoospermia, reduced percentage of motile spermatozoa and abnormal sperm morphology. Results The interval from the time of the second vaccination to the date of participation was on average 37 days, with most subjects describing either mild or no side effects after the first or second dose. The mean sperm concentration was 63.2 ± 33.6 × 106/ml, with only a single participant (1.3%) with a sperm count of 12.5 × 106/ml, considered by the WHO to be oligozoospermic. The mean sperm motility percentage was 64.5 ± 16.7%, with only a single man (1.3%) displaying reduced motility. No notable morphological abnormalities were observed. This constituted a lower percentage of abnormal semen parameters compared with the 5% rates reported in fertile men by the WHO. Conclusions The semen parameters following COVID-19 vaccination were predominantly within the normal reference ranges as set by the WHO and do not reflect any causative detrimental effect from COVID-19 vaccination. The results strengthen the notion that the Pfizer's severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine is safe and should be recommended to men wishing to conceive.read more
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The BNT162b2 mRNA Covid-19 vaccine does not impair sperm parameters
TL;DR: In this paper , the BNT162b2 COVID-19 vaccine does not seem to affect sperm parameters, and sperm parameters showed no significant changes after vaccination among men with a normal and abnormal semen analysis.
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COVID-19 Vaccination Does Not Affect Reproductive Health Parameters in Men
Marco Reschini,Luca Pagliardini,Luca Boeri,Francesca Piazzini,Veronica Bandini,Gianfranco Fornelli,C Dolci,Greta Chiara Cermisoni,Paola Viganò,Edgardo Somigliana,Maria Elisabetta Coccia,Enrico Papaleo +11 more
TL;DR: COVID-19 vaccination did not affect sperm quality and fertilization capacity of men undergoing ART treatments and should be considered safe for men's reproductive health.
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No Effect of Inactivated SARS-CoV-2 Vaccination on in vitro Fertilization Outcomes: A Propensity Score-Matched Study
TL;DR: In this paper , the authors investigated the impact of inactivated SARS-CoV-2 vaccination on in vitro fertilization (IVF) outcomes, and provided the first-time evidence that SARS vaccination in females did not result in any measurable detrimental effects on IVF treatment.
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Covid‐19 vaccination BNT162b2 temporarily impairs semen concentration and total motile count among semen donors
TL;DR: Systemic immune response after BNT162b2 vaccine is a reasonable cause for transient semen concentration and TMC decline and long-term prognosis remains good.
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The impact of COVID-19 vaccines on fertility-A systematic review and meta-analysis
TL;DR: In this article , a systematic review was conducted to answer the question: Is there any impact of COVID-19 vaccines on the fertility of men and women of reproductive age? PubMed, Scopus, Web of Science, Cochrane and Embase databases were searched for eligible studies until June 8th, 2022.
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