Does the addition of time-lapse morphokinetics in the selection of embryos for transfer improve pregnancy rates? A randomized controlled trial
Reads0
Chats0
TLDR
The addition of time-lapse morphokinetic data did not significantly improve clinical reproductive outcomes in all patients and in those with blastocyst transfers, and absence of multinucleation, timing of blastulation, and Morphokinetic score were found to be associated with blastocytes implantation rates.About:
This article is published in Fertility and Sterility.The article was published on 2016-02-01 and is currently open access. It has received 162 citations till now. The article focuses on the topics: Embryo transfer & Pregnancy rate.read more
Citations
More filters
Journal ArticleDOI
Time-lapse systems for embryo incubation and assessment in assisted reproduction.
TL;DR: The potential advantages of a TLS include the ability to maintain a stable culture environment, therefore limiting the exposure of embryos to changes in gas composition, temperature and movement, and improving embryo selection for ART treatment by utilising additional information gained through monitoring embryo development.
Journal ArticleDOI
Deep learning as a predictive tool for fetal heart pregnancy following time-lapse incubation and blastocyst transfer
TL;DR: A retrospective analysis demonstrating that the deep learning model has a high level of predictability of the likelihood that an embryo will implant and may improve the effectiveness of previous approaches used for time-lapse imaging in embryo selection.
Journal ArticleDOI
Development of a generally applicable morphokinetic algorithm capable of predicting the implantation potential of embryos transferred on Day 3
TL;DR: The algorithm presented here can be used independently of culture conditions and fertilization method and provides predictive power not surpassed by other published algorithms for ranking embryos according to their blastocyst formation potential.
Journal ArticleDOI
Assessment of human embryo development using morphological criteria in an era of time-lapse, algorithms and 'OMICS': is looking good still important?
David K. Gardner,Basak Balaban +1 more
TL;DR: It is proposed that key features, such as multinucleation, cell size and blastocyst differentiation should be included in future iterations of selection/deselection algorithms.
Journal ArticleDOI
Time-lapse culture with morphokinetic embryo selection improves pregnancy and live birth chances and reduces early pregnancy loss: a meta-analysis
TL;DR: Although time-lapse is shown to significantly improve overall clinical outcome, further high-quality evidence is needed before universal conclusions can be drawn, and selective application and variability were also limitations.
References
More filters
Journal ArticleDOI
The use of morphokinetics as a predictor of embryo implantation
TL;DR: A multivariable model is proposed based on the findings to classify embryos according to their probability of implantation and it is proposed that the image acquisition and time-lapse analysis system makes it possible to determine exact timing of embryo cleavages in a clinical setting.
Journal ArticleDOI
Non-invasive imaging of human embryos before embryonic genome activation predicts development to the blastocyst stage
Wong Connie C,Kevin E. Loewke,Nancy L. Bossert,Barry Behr,Christopher J. De Jonge,Thomas M. Baer,Renee A. Reijo Pera +6 more
TL;DR: It is found that success in progression to the blastocyst stage can be predicted with >93% sensitivity and specificity by measuring three dynamic, noninvasive imaging parameters by day 2 after fertilization, before embryonic genome activation (EGA).
Journal ArticleDOI
A formula for scoring human embryo growth rates in in vitro fertilization: its value in predicting pregnancy and in comparison with visual estimates of embryo quality.
TL;DR: EQ and EDR were significantly associated with each other and together provide a valuable guide in predicting pregnancy, in selecting embryos for freezing, and in monitoring day-to-day performance in the in vitro fertilization (IVF) program.
Journal ArticleDOI
Early cleavage of in-vitro fertilized human embryos to the 2-cell stage: a novel indicator of embryo quality and viability.
TL;DR: A new method to evaluate embryo viability based on the timing of the first cell division is proposed, 'early cleavage' as a simple and effective non-invasive method for selection and evaluation of embryos prior to transfer.
Journal ArticleDOI
Embryo incubation and selection in a time-lapse monitoring system improves pregnancy outcome compared with a standard incubator: a retrospective cohort study
Marcos Meseguer,I. Rubio,María del Carmen de la Orden de la Cruz,N. Basile,Julián Marcos,Antonio Requena +5 more
TL;DR: Analysis of retrospective data indicated that culturing and selecting embryos by TMS significantly improved the relative probability of clinical pregnancy and was attributed to a combination of stable culture conditions and the use of morphokinetic parameters for embryo selection.