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Dual role of quercetin in enhancing the efficacy of cisplatin in chemotherapy and protection against its side effects: a review
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TLDR
This review investigates the dual role of quercetin in enhancing anti-tumour activity of cisplatin and simultaneous reduction in its adverse effects.Abstract:
Chemotherapy has opened a new window in cancer therapy. However, the resistance of cancer cells has dramatically reduced the efficacy of chemotherapy. Cisplatin is a chemotherapeutic agent and its potential in cancer therapy has been restricted by resistance of cancer cells. As a consequence, the scientists have attempted to find new strategies in elevating chemotherapy efficacy. Due to great anti-tumour activity, naturally occurring compounds are of interest in polychemotherapy. Quercetin is a flavonoid with high anti-tumour activity against different cancers that can be used with cisplatin to enhance its efficacy and also are seen to sensitise cancer cells into chemotherapy. Furthermore, cisplatin has side effects such as nephrotoxicity and ototoxicity. Administration of quercetin is advantageous in reducing the adverse effects of cisplatin without compromising its anti-tumour activity. In this review, we investigate the dual role of quercetin in enhancing anti-tumour activity of cisplatin and simultaneous reduction in its adverse effects.read more
Citations
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Caffeic acid and its derivatives as potential modulators of oncogenic molecular pathways: New hope in the fight against cancer.
Sepideh Mirzaei,Mohammad Hossein Gholami,Amirhossein Zabolian,Hossein Saleki,Mahdi Vasheghani Farahani,Soodeh Hamzehlou,Fatemeh Bakhtiari Far,Seyed Omid Sharifzadeh,Saeed Samarghandian,Haroon Khan,Amir Reza Aref,Milad Ashrafizadeh,Ali Zarrabi,Gautam Sethi +13 more
TL;DR: In this article, a review of the potential of CA and its derivatives in cancer therapy is presented, with a focus on molecular pathways to pave the way for rapid translation of CA for clinical use.
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Non-coding RNAs and macrophage interaction in tumor progression.
Maliheh Entezari,Mehrdokht Sadrkhanloo,Mohsen Rashidi,Sholeh Etehad Asnaf,Afshin Taheriazam,M. Hashemi,Milad Ashrafizadeh,Ali Zarrabi,Navid Rabiee,Kiavash Hushmandi,Sepideh Mirzaei,Gautam Sethi +11 more
TL;DR: In this paper , the role of non-coding RNAs (ncRNAs) and exosomal ncRNAs derived from tumor cells or macrophages can be considered as non-invasive biomarkers for tumor diagnosis.
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Effect of Quercetin-Loaded Mesoporous Silica Nanoparticles on Myocardial Ischemia-Reperfusion Injury in Rats and Its Mechanism.
TL;DR: In this paper, the effect of quercetin-loaded mesoporous silica nanoparticles (Q-MSNs) on myocardial ischemia-reperfusion injury in rats and its mechanism was investigated.
DNA Damage-Mediated Induction of a Chemoresistant Niche
TL;DR: It is shown that paracrine factors in the tumor microenvironment modulate lymphoma cell survival following the administration of genotoxic chemotherapy, creating a "chemo-resistant niche" that promotes the survival of a minimal residual tumor burden and serves as a reservoir for eventual tumor relapse.
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Flavonoids-Based Delivery Systems towards Cancer Therapies
TL;DR: This review is to present the most reliable flavonoids-based delivery systems developed for anticancer therapies and the progress accomplished, with a special focus on cervical cancer therapy, and highlights the relevance of delivery systems application.
References
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Drug Resistance and the Solid Tumor Microenvironment
TL;DR: How the tumor microenvironment may be involved in the resistance of solid tumors to chemotherapy and potential strategies to improve the effectiveness of drug treatment by modifying factors relating to the tumormicroenvironment are described.
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Hepatocellular carcinoma pathogenesis: from genes to environment
TL;DR: The current state of knowledge of hepatitis C, the most common and dreaded liver neoplasm, is summarized, and the principal challenges and scientific opportunities that are relevant to controlling this accelerating global health crisis are highlighted.