Dynamic Fungal Cell Wall Architecture in Stress Adaptation and Immune Evasion.
TLDR
This review focuses on dynamics of the fungal polysaccharide cell wall, which plays an outsized role in fungal pathogenesis and therapy because it acts as both an environmental barrier and as the major interface with the host immune system.About:
This article is published in Trends in Microbiology.The article was published on 2018-04-01 and is currently open access. It has received 112 citations till now. The article focuses on the topics: Population & Modern medicine.read more
Citations
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Multiscale Simulations of Biological Membranes: The Challenge To Understand Biological Phenomena in a Living Substance.
TL;DR: This review discusses the current state-of-the-art of biomembrane simulations that, until now, have largely focused on a rather narrow picture of the complexity of the membranes, and discusses the challenges that should unravel in the foreseeable future.
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Hypoxia Promotes Immune Evasion by Triggering β-Glucan Masking on the Candida albicans Cell Surface via Mitochondrial and cAMP-Protein Kinase A Signaling
Arnab Pradhan,Gabriela Mol Avelar,Judith M. Bain,Delma S. Childers,Daniel E. Larcombe,Mihai G. Netea,Elena Shekhova,Carol A. Munro,Gordon D. Brown,Lars P. Erwig,Lars P. Erwig,Neil A. R. Gow,Alistair J. P. Brown +12 more
TL;DR: It is shown that adaptation to hypoxia in the major fungal pathogen of humans Candida albicans includes changes in cell wall structure and reduced exposure, at the cell surface, of β-glucan, a key pathogen-associated molecular pattern (PAMP).
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The fungal cell wall as a target for the development of new antifungal therapies
TL;DR: The fungal cell wall and its relevance in biotechnology as a target for the development of new antifungal compounds is reviewed, disclosing the most promising cell wall inhibitors that are currently in experimental or clinical development for the treatment of some invasive mycoses.
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Polysaccharides of mushroom Pleurotus spp.: New extraction techniques, biological activities and development of new technologies
Jhonatas Rodrigues Barbosa,Maurício Madson dos Santos Freitas,Luiza Helena da Silva Martins,Raul Nunes de Carvalho Junior +3 more
TL;DR: This review seeks to revisit the genus Pleurotus, making an updated approach on the recent discoveries of polysaccharides, new extraction techniques and bioactivities, emphasising on their mechanisms and routes in order to update the reader on the recently technologies related to these polymers.
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Vaccines for human fungal diseases: close but still a long way to go.
TL;DR: A review of the progress that has been made and the challenges that lie ahead in the quest towards efficacious fungal vaccines can be found in this paper, where the authors present three vaccines that have reached human clinical trials.
References
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Hidden Killers: Human Fungal Infections
Gordon D. Brown,David W. Denning,Neil A. R. Gow,Stuart M. Levitz,Mihai G. Netea,Theodore C. White +5 more
TL;DR: The importance of fungi as human pathogens is highlighted and the challenges the authors face in combating the devastating invasive infections caused by these microorganisms are discussed, in particular in immunocompromised individuals.
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Emerging fungal threats to animal, plant and ecosystem health.
Matthew C. Fisher,Daniel A. Henk,Cheryl J. Briggs,John S. Brownstein,Lawrence C. Madoff,Sarah L. McCraw,Sarah J. Gurr +6 more
TL;DR: It is argued that nascent fungal infections will cause increasing attrition of biodiversity, with wider implications for human and ecosystem health, unless steps are taken to tighten biosecurity worldwide.
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Immune recognition. A new receptor for beta-glucans.
Gordon D. Brown,Siamon Gordon +1 more
TL;DR: This work identifies this unknown receptor on macrophages as dectin-1 (ref. 2), a finding that provides new insights into the innate immune recognition of β-glucans.
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Cell Wall Integrity Signaling in Saccharomyces cerevisiae
TL;DR: This review discusses recent advances in understanding the various signal transduction pathways that allow cells to monitor the state of the cell wall and respond to environmental challenges to this structure.
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Regulation of Cell Wall Biogenesis in Saccharomyces cerevisiae: The Cell Wall Integrity Signaling Pathway
TL;DR: This review article centers on CWI signaling in Saccharomyces cerevisiae through the cell cycle and in response to cell wall stress.