A
Alex Hopke
Researcher at Harvard University
Publications - 30
Citations - 970
Alex Hopke is an academic researcher from Harvard University. The author has contributed to research in topics: Candida albicans & Medicine. The author has an hindex of 10, co-authored 23 publications receiving 675 citations. Previous affiliations of Alex Hopke include University of Maine & Shriners Hospitals for Children.
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Journal ArticleDOI
Differential Adaptation of Candida albicans In Vivo Modulates Immune Recognition by Dectin-1
Mohlopheni J. Marakalala,Simon Vautier,Joanna Potrykus,Louise A. Walker,Kelly M. Shepardson,Alex Hopke,Héctor M. Mora-Montes,Ann M. Kerrigan,Mihai G. Netea,Graeme I. Murray,Donna M. MacCallum,Robert T. Wheeler,Carol A. Munro,Neil A. R. Gow,Robert A. Cramer,Alistair J. P. Brown,Gordon D. Brown,Gordon D. Brown +17 more
TL;DR: It is established that differences in the levels of cell-wall chitin influence the role of Dectin-1, and that these effects can be modulated by antifungal drug treatment and have significant implications for the understanding of susceptibility and treatment of human infections with this pathogen.
Journal ArticleDOI
Differential adaptation of Candida albicans in vivo modulates immune recognition by dectin-1
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Dynamic Fungal Cell Wall Architecture in Stress Adaptation and Immune Evasion.
TL;DR: This review focuses on dynamics of the fungal polysaccharide cell wall, which plays an outsized role in fungal pathogenesis and therapy because it acts as both an environmental barrier and as the major interface with the host immune system.
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Humoral signatures of protective and pathological SARS-CoV-2 infection in children.
Yannic C. Bartsch,Chuangqi Wang,Tomer Zohar,Tomer Zohar,Stephanie Fischinger,Caroline Atyeo,John S. Burke,Jaewon Kang,Andrea G. Edlow,Alessio Fasano,Lindsey R. Baden,Eric J. Nilles,Ann E. Woolley,Elizabeth W. Karlson,Alex Hopke,Daniel Irimia,Eric S. Fischer,Edward T. Ryan,Richelle C. Charles,Boris Julg,Douglas A. Lauffenburger,Lael M. Yonker,Galit Alter +22 more
TL;DR: Using systems serology, the authors found that in children with acute mild COVID-19 a functional phagocyte and complement-activating IgG response to SARS-CoV-2, similar to the acute responses generated in adults with mild disease.
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Neutrophil attack triggers extracellular trap-dependent Candida cell wall remodeling and altered immune recognition
TL;DR: It is found that fungal epitope unmasking requires an active fungal response in addition to the stimulus provided by neutrophil attack, which highlights the important but underappreciated concept that pattern recognition during infection is dynamic and depends on the host-pathogen dialog.