Journal ArticleDOI
Early decline in the catecholamine release-inhibitory peptide catestatin in humans at genetic risk of hypertension.
Daniel T. O'Connor,Mala T. Kailasam,Brian P. Kennedy,Michael G. Ziegler,Noboru Yanaihara,Robert J. Parmer +5 more
TLDR
It is concluded that catestatin is diminished early in the course of development of hypertension, even in the normotensive offspring of patients with the disease.Abstract:
Background Hypertension is a complex trait with an ill-defined genetic predisposition, in which adrenergic mechanisms seem to be involved even at the early stages. Chromogranin A is a pro-hormone stored and released with catecholamines by exocytosis; its fragment catestatin, formed in vivo, inhibitsread more
Citations
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The Chromogranin–Secretogranin Family
TL;DR: The members of the chromogranin–secretogran in family of peptide hormones, biogenic amines, and neurotransmitters are enclosed within vesicles in the neuroendocrine system and a variety of neurons.
Journal ArticleDOI
Hypertension from targeted ablation of chromogranin A can be rescued by the human ortholog
Nitish R. Mahapatra,Daniel T. O'Connor,Sucheta M. Vaingankar,Amiya P. Sinha Hikim,Manjula Mahata,Saugata Ray,Eugenie Staite,Hongjiang Wu,Yusu Gu,Nancy D. Dalton,Brian P. Kennedy,Michael G. Ziegler,John Ross,Sushil K. Mahata +13 more
TL;DR: Loss of the physiological "brake" catestatin in Chga mice coupled with dysregulation of transmitter storage and release may act in concert to alter autonomic control of the circulation in vivo, eventuating in hypertension.
Journal ArticleDOI
The Extended Granin Family: Structure, Function, and Biomedical Implications
Alessandro Bartolomucci,Roberta Possenti,Sushil K. Mahata,Reiner Fischer-Colbrie,Y. Peng Loh,Stephen R.J. Salton +5 more
TL;DR: The structure and function of granins and granin-derived peptides and expansive new genetic evidence are reviewed, including recent single-nucleotide polymorphism mapping, genomic sequence comparisons, and analysis of transgenic and knockout mice, which together support an important and evolutionarily conserved role for these proteins in large dense-core vesicle biogenesis and regulated secretion.
Journal ArticleDOI
The granin family of uniquely acidic proteins of the diffuse neuroendocrine system: comparative and functional aspects.
TL;DR: The chromogranins A and B and SgII constitute the main members of a family of uniquely acidic secretory proteins in elements of the diffuse neuroendocrine system, characterised by numerous pairs of basic amino acids as potential cleavage sites for processing by the co‐stored prohormone converting enzymes PC 1/3 and PC2.
Journal ArticleDOI
The Antihypertensive Chromogranin A Peptide Catestatin Acts as a Novel Endocrine/Paracrine Modulator of Cardiac Inotropism and Lusitropism
Tommaso Angelone,A.M. Quintieri,Bhawanjit K. Brar,Pauline T. Limchaiyawat,Bruno Tota,Sushil K. Mahata,Maria Carmela Cerra +6 more
TL;DR: The cardioinhibitory influence exerted on basal mechanical performance and the counterregulatory action against beta-adrenergic and endothelin-1 stimulations point to Cts as a novel cardiac modulator, able to protect the heart against excessive sympathochromaffin overactivation, e.g. hypertensive cardiomyopathy.
References
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Journal ArticleDOI
Genetic dissection of complex traits.
TL;DR: This article synthesizes the current state of the genetic dissection of complex traits--describing the methods, limitations, and recent applications to biological problems.
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Obesity and impaired prohormone processing associated with mutations in the human prohormone convertase 1 gene
Robert S. Jackson,John W.M. Creemers,Shinya Ohagi,Marie-Laure Raffin-Sanson,Louise Sanders,C. T. Montague,John C. Hutton,Stephen O'Rahilly +7 more
TL;DR: It is inferred that molecular defects in prohormone conversion may represent a generic mechanism for obesity, common to humans and rodents.
Journal ArticleDOI
Novel autocrine feedback control of catecholamine release. A discrete chromogranin a fragment is a noncompetitive nicotinic cholinergic antagonist.
Sushil K. Mahata,Daniel T. O'Connor,Manjula Mahata,Seung Hyun Yoo,Laurent Taupenot,Hongjiang Wu,B. M. Gill,R J Parmer +7 more
TL;DR: This small domain within chromogranin A may contribute to a novel, autocrine, homeostatic (negative-feedback) mechanism controlling catecholamine release from chromaffin cells and neurons.