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ECPPA: Randomised trial of low dose aspirin for the prevention of maternal and fetal complications in high risk pregnant women

Álvaro Nagib Atallah, +194 more
- 01 Jan 1996 - 
- Vol. 103, Iss: 1, pp 39-47
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TLDR
The objective was to determine the effectiveness of low dose aspirin in women at high risk of adverse outcomes associated with pre‐eclampsia.
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This article is published in British Journal of Obstetrics and Gynaecology.The article was published on 1996-01-01 and is currently open access. It has received 130 citations till now.

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Journal ArticleDOI

Platelet-Active Drugs: The Relationships Among Dose, Effectiveness, and Side Effects

TL;DR: Abbreviations: ACE trial 5 Acetylsalicylic Acid and Carotid Endarterectomy; CAPRIE study 5 Clopidogrel vs Aspirin in Patients at Risk of Ischemic Events; CI 5 confidence interval; COX 5 cyclooxygenase; DVT 5 deep venous thrombosis; EPISTENT trial 5 Evaluation of Platelet IIb/IIIa Inhibitors for Stenting.
Reference EntryDOI

Calcium supplementation during pregnancy for preventing hypertensive disorders and related problems

TL;DR: The average risk of high blood pressure was reduced with calcium supplementation compared with placebo and the composite outcome maternal death or serious morbidity was reduced, but there was an anomalous increase in the risk of HELLP.
Journal ArticleDOI

Prevention of preeclampsia and intrauterine growth restriction with aspirin started in early pregnancy: a meta-analysis

TL;DR: Low-dose aspirin initiated in early pregnancy is an efficient method of reducing the incidence of preeclampsia and intrauterine growth restriction and IUGR.
Journal ArticleDOI

Antiplatelet agents for prevention of pre-eclampsia: a meta-analysis of individual patient data

TL;DR: Antiplatelet agents during pregnancy are associated with moderate but consistent reductions in the relative risk of pre-eclampsia, of birth before 34 weeks' gestation, and of having a pregnancy with a serious adverse outcome.
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Journal Article

Collaborative overview of randomized trials of antiplatelet therapy .1. prevention of death, myocardial-infarction, and stroke by prolonged antiplatelet therapy in various categories of patients

R Altman, +418 more
- 08 Jan 1994 - 
TL;DR: There was no appreciable evidence that either a higher aspirin dose or any other antiplatelet regimen was more effective than medium dose aspirin in preventing vascular events, so in each of the four main high risk categories overall mortality was significantly reduced.
Journal ArticleDOI

Low-dose aspirin prevents pregnancy-induced hypertension and pre-eclampsia in angiotensin-sensitive primigravidae.

TL;DR: Low-dose aspirin may restore prostacyclin/thromboxane imbalance, previously suggested as an important aetiological factor in PIH and pre-eclampsia, and be reinstated in mothers or infants.
Journal ArticleDOI

Clasp - a randomized trial of low-dose aspirin for the prevention and treatment of preeclampsia among 9364 pregnant-women

G Beroyz, +566 more
- 12 Mar 1994 - 
TL;DR: The findings do not support routine prophylactic or therapeutic administration of antiplatelet therapy in pregnancy to all women at increased risk of pre-eclampsia or IUGR, but low-dose aspirin may be justified in women judged to be especially liable to early-onset pre- eClampsia severe enough to need very preterm delivery.
Journal ArticleDOI

Prevention of pre-eclampsia by early antiplatelet therapy

TL;DR: Antiplatelet therapy given early in pregnancy to high-risk patients may protect against pre-eclampsia and fetal growth retardation.
Related Papers (5)

Clasp - a randomized trial of low-dose aspirin for the prevention and treatment of preeclampsia among 9364 pregnant-women

G Beroyz, +566 more
- 12 Mar 1994 -