Effect of circumcision of HIV-negative men on transmission of human papillomavirus to HIV-negative women: a randomised trial in Rakai, Uganda
Maria J. Wawer,Aaron A.R. Tobian,Godfrey Kigozi,Xiangrong Kong,Patti E. Gravitt,David Serwadda,Fred Nalugoda,Frederick Makumbi,Victor Ssempiija,Nelson K. Sewankambo,Stephen Watya,Kevin P. Eaton,Amy E. Oliver,Michael Z. Chen,Steven J. Reynolds,Steven J. Reynolds,Thomas C. Quinn,Thomas C. Quinn,Ronald H. Gray +18 more
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TLDR
The findings indicate that male circumcision should now be accepted as an efficacious intervention for reducing the prevalence and incidence of HPV infections in female partners.About:
This article is published in The Lancet.The article was published on 2011-01-15 and is currently open access. It has received 190 citations till now. The article focuses on the topics: Acquired immunodeficiency syndrome (AIDS) & Randomized controlled trial.read more
Citations
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Journal ArticleDOI
Voluntary medical male circumcision: modeling the impact and cost of expanding male circumcision for HIV prevention in eastern and southern Africa.
Emmanuel Njeuhmeli,Steven Forsythe,Jason Reed,Marjorie Opuni,Lori Bollinger,Nathan Heard,Delivette Castor,John Stover,Timothy M.M. Farley,Veena Menon,Catherine Hankins +10 more
TL;DR: It is found that reaching 80% coverage and maintaining it until 2025 would avert 3.36 million new HIV infections, and the impact and cost of scaling up adult medical male circumcision in 13 priority countries in eastern and southern Africa is estimated to be $1.3bn.
Journal ArticleDOI
HIV prevention transformed: the new prevention research agenda
Nancy Padian,Nancy Padian,Sandra I. McCoy,Salim S. Abdool Karim,Salim S. Abdool Karim,Nina. Hasen,Julia. Kim,Michael Bartos,Elly Katabira,Stefano M. Bertozzi,Stefano M. Bertozzi,Bernhard Schwartländer,Myron S. Cohen +12 more
TL;DR: In this paper, the authors analyse trends in the rapidly changing landscape of HIV prevention, and chart a new path for HIV prevention research that focuses on the implementation of effective and efficient combination prevention strategies to turn the tide on the HIV pandemic.
Journal ArticleDOI
Epidemiology and burden of HPV infection and related diseases: implications for prevention strategies.
TL;DR: HPV 16 and 18 are responsible for 70% of cervical cancer cases and, especially HPV 16, for a large proportion of other cancers, and prophylactic vaccination targeting these genotypes is expected to have a major impact on the burden of cervicalcancer as well as that of other HPV-related cancers.
Journal ArticleDOI
The Burden of Human Papillomavirus Infections and Related Diseases in Sub-Saharan Africa
Hugo De Vuyst,Laia Alemany,Charles J.N. Lacey,Carla J. Chibwesha,Vikrant V. Sahasrabuddhe,Cecily Banura,Lynette Denny,Groesbeck P. Parham +7 more
TL;DR: Strategies to reduce the excessive burden of HPV-related diseases in SSA include age-appropriate prophylactic HPV vaccination, cervical cancer prevention services for women of the reproductive ages, and control of HIV/AIDS.
Journal ArticleDOI
Clinical trials of human papillomavirus vaccines and beyond
Matti Lehtinen,Joakim Dillner +1 more
TL;DR: A strong increase in vaccine efficacy with increasing severity of the precancerous lesion is explained by accumulation of the most-oncogenic HPV types 16 and 18 in these lesions, and prophylactic HPV vaccination will exceed the best results from screening for cancer.
References
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Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008.
TL;DR: The results for 20 world regions are presented, summarizing the global patterns for the eight most common cancers, and striking differences in the patterns of cancer from region to region are observed.
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Longitudinal data analysis using generalized linear models
Kung Yee Liang,Scott L. Zeger +1 more
TL;DR: In this article, an extension of generalized linear models to the analysis of longitudinal data is proposed, which gives consistent estimates of the regression parameters and of their variance under mild assumptions about the time dependence.
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Epidemiologic Classification of Human Papillomavirus Types Associated with Cervical Cancer
Nubia Muñoz,F. Xavier Bosch,Silvia de Sanjosé,Rolando Herrero,Xavier Castellsagué,Keerti V. Shah,Peter J.F. Snijders,Chris J.L.M. Meijer +7 more
TL;DR: In addition to HPV types 16 and 18, types 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 68, 73, and 82Should be considered carcinogenic, or high-risk, types, and types 26, 53, and 66 should be considered probably carcinogenic.
Journal ArticleDOI
Randomized, controlled intervention trial of male circumcision for reduction of HIV infection risk: the ANRS 1265 Trial.
Bertran Auvert,Dirk Taljaard,Emmanuel Lagarde,Joelle Sobngwi-Tambekou,Rémi Sitta,Adrian Puren +5 more
TL;DR: Male circumcision provides a degree of protection against acquiring HIV infection, equivalent to what a vaccine of high efficacy would have achieved in sub-Saharan Africa.
Journal ArticleDOI
Human papillomavirus and cervical cancer
TL;DR: The new HPV-oriented model of cervical carcinogenesis should gradually replace older morphological models based only on cytology and histology, and can minimise the incidence of cervical cancer, and the morbidity and mortality it causes, even in low-resource settings.
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Male circumcision for HIV prevention in men in Rakai, Uganda: a randomised trial
Ronald H. Gray,Godfrey Kigozi,David Serwadda,Frederick Makumbi,Stephen Watya,Fred Nalugoda,Noah Kiwanuka,Lawrence H. Moulton,Mohammad A Chaudhary,Michael Z. Chen,Nelson K. Sewankambo,Fred Wabwire-Mangen,Melanie C. Bacon,Carolyn Williams,Pius Opendi,Steven J. Reynolds,Steven J. Reynolds,Oliver Laeyendecker,Oliver Laeyendecker,Thomas C. Quinn,Thomas C. Quinn,Maria J. Wawer +21 more