Effect of COVID-19 on Male Reproductive System - A Systematic Review.
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In this paper, the authors reviewed the relevant publications on the possible impact of Coronavirus Disease 2019 (COVID-19) on male reproductive system and summarized the latest and most important research results so far.Abstract:
Background Angiotensin-converting enzyme II (ACE2), a receptor for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) to enter host cells, is widely expressed in testes and prostate tissues. The testis and prostate produce semen. At present, there are contradictory reports about whether SARS-CoV-2 can exist in the semen of infected men. Objective To provide a comprehensive overview of the topic of whether COVID-19 can impact on male reproductive system. Methods We reviewed the relevant publications on the possible impact of Coronavirus Disease 2019 (COVID-19) on male reproductive system and summarized the latest and most important research results so far. Literature published in English from December 2019 to January 31, 2021 regarding the existence of SARS-CoV-2 in semen, testis, and prostatic fluid and the effects of COVID-19 on male reproductive were included. Results We identified 28 related studies, only one of which reported the presence of SARS-CoV-2 in semen. The study found that the semen quality of patients with moderate infection was lower than that of patients with mild infection and healthy controls. The impaired semen quality may be related to fever and inflammation. Pathological analysis of the testis/epididymis showed that SARS-CoV-2 viral particles were positive in 10 testicular samples, and the spermatogenic function of the testis was impaired. All 94 expressed prostatic secretion (EPS) samples were negative for SARS-CoV-2 RNA. Conclusion The likelihood of SARS-CoV-2 in the semen of COVID-19 patients is very small, and semen should rarely be regarded as a carrier of SARS-CoV-2 genetic material. However, COVID-19 may cause testicular spermatogenic dysfunction via immune or inflammatory reactions. Long-term follow-up is needed for COVID-19 male patients and fetuses conceived during the father's infection period.read more
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Journal ArticleDOI
Does mRNA SARS-CoV-2 vaccine detrimentally affect male fertility, as reflected by semen analysis?
Dror Lifshitz,Dror Lifshitz,Dror Lifshitz,Jigal Haas,Jigal Haas,Oshrit Lebovitz,Oshrit Lebovitz,Gil Raviv,Gil Raviv,Raoul Orvieto,Raoul Orvieto,Adva Aizer,Adva Aizer +12 more
TL;DR: In this paper, a prospective cohort study was conducted at a single large tertiary centre in Israel between February and March of 2021, where semen samples from 75 fertile men were analyzed 1-2 months following their second dose of Pfizer's COVID-19 vaccine.
Journal ArticleDOI
Does mRNA SARS-CoV-2 vaccine detrimentally affect male fertility, as reflected by semen analysis?
TL;DR: A prospective cohort study was conducted at a single large tertiary centre in Israel between February and March of 2021 as mentioned in this paper , where semen samples from 75 fertile men were analyzed 1-2 months following their second dose of Pfizer's COVID-19 vaccine.
Journal ArticleDOI
Andrological effects of SARS-Cov-2 infection: a systematic review and meta-analysis
Giovanni Corona,Walter Vena,Alessandro Pizzocaro,Fabrizio Pallotti,Donatella Paoli,Giulia Rastrelli,Elisabetta Baldi,Nicola Cilloni,Mauro Gacci,F Semeraro,Andrea Salonia,Shailender Minhas,Rosario Pivonello,Alessandra Sforza,Linda Vignozzi,Andres Isidori,Andrea Lenzi,Mattia Maggi,Francesco Lombardo +18 more
TL;DR: In this article , the authors evaluated the available evidence regarding possible andrological consequences of COVID-19 either on seminal or hormonal parameters, and showed that the use of mRNA CoV-19 vaccines does not affect sperm quality.
Journal ArticleDOI
COVID-19 Vaccination Does Not Affect Reproductive Health Parameters in Men
Marco Reschini,Luca Pagliardini,Luca Boeri,Francesca Piazzini,Veronica Bandini,Gianfranco Fornelli,C Dolci,Greta Chiara Cermisoni,Paola Viganò,Edgardo Somigliana,Maria Elisabetta Coccia,Enrico Papaleo +11 more
TL;DR: COVID-19 vaccination did not affect sperm quality and fertilization capacity of men undergoing ART treatments and should be considered safe for men's reproductive health.
Journal ArticleDOI
SARS-CoV-2 infection and multi-organ system damage: A review
Ali A. Rabaan,Samira Smajlovic,Huseyin Tombuloglu,Sabahudin Cordic,Azra Hajdarević,Nudzejma Kudic,Abbas Al Mutai,Safaa A. Turkistani,Shamsah H. Al-Ahmed,Nisreen A. Al-Zaki,Mona J. Al Marshood,Amal Alfaraj,Saad Alhumaid,Ebtesam A. Al-Suhaimi +13 more
TL;DR: The study comprehensively elucidates the most recent studies on the effects of SARS-CoV-2 infection on multiple organs and systems, including respiratory, cardiovascular, gastrointestinal, renal, nervous, endocrine, reproductive, immune, and parts of the integumentary system.
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