Effect of non-steroidal anti-inflammatory drugs on radiographic spinal progression in patients with axial spondyloarthritis: results from the German Spondyloarthritis Inception Cohort
Denis Poddubnyy,Martin Rudwaleit,Hildrun Haibel,Joachim Listing,Elisabeth Märker-Hermann,Henning Zeidler,Jürgen Braun,Joachim Sieper +7 more
Reads0
Chats0
TLDR
A high NSAIDs intake over 2 years is associated with retarded radiographic spinal progression in AS, and in non-radiographic axial SpA this effect is less evident, probably due to a low grade of new bone formation in the spine at this stage.Abstract:
Objective To investigate the influence of non-steroidal anti-inflammatory drugs (NSAIDs) intake on radiographic spinal progression over 2 years in patients with ankylosing spondylitis (AS) and non-radiographic axial spondyloarthritis (SpA). Methods 164 patients with axial SpA (88 with AS and 76 with non-radiographic axial SpA) were selected for this analysis based on availability of spinal radiographs at baseline and after 2 years of follow-up and the data on NSAIDs intake. Spinal radiographs were scored by two trained readers in a concealed randomly selected order according to the modified Stoke Ankylosing Spondylitis Spine Score (mSASSS) system. An index of the NSAID intake counting both dose and duration of drug intake was calculated. Results High NSAIDs intake (NSAID index≥50) in AS was associated with lower likelihood of significant radiographic progression defined as an mSASSS worsening by ≥2 units: OR=0.15, 95% CI 0.02 to 0.96, p=0.045 (adjusted for baseline structural damage, elevated C reactive protein (CRP) and smoking status) in comparison with patients with low NSAIDs intake (NSAID index Conclusion A high NSAIDs intake over 2 years is associated with retarded radiographic spinal progression in AS. In non-radiographic axial SpA this effect is less evident, probably due to a low grade of new bone formation in the spine at this stage.read more
Citations
More filters
Journal ArticleDOI
2016 update of the ASAS-EULAR management recommendations for axial spondyloarthritis
Désirée van der Heijde,Sofia Ramiro,Robert Landewé,Xenofon Baraliakos,Filip Van den Bosch,Alexandre Sepriano,Alexandre Sepriano,Andrea Regel,Adrian Ciurea,Hanne Dagfinrud,Maxime Dougados,Maxime Dougados,Floris A. van Gaalen,Pál Géher,Irene E. van der Horst-Bruinsma,Robert D. Inman,Merryn Jongkees,Uta Kiltz,Tore K Kvien,Pedro Machado,Helena Marzo-Ortega,Anna Molto,Anna Molto,Victoria Navarro-Compán,Salih Ozgocmen,Fernando Pimentel-Santos,John D. Reveille,Martin Rudwaleit,Martin Rudwaleit,J. Sieper,Percival D. Sampaio-Barros,Dieter Wiek,Jürgen Braun +32 more
TL;DR: The 2016 Assessment of SpondyloArthritis international Society-EULAR recommendations provide up-to-date guidance on the management of patients with axSpA and three overarching principles and 13 recommendations deal with surgery and spinal fractures.
Journal ArticleDOI
Treating spondyloarthritis, including ankylosing spondylitis and psoriatic arthritis, to target: recommendations of an international task force
Josef S Smolen,Jürgen Braun,Maxime Dougados,Paul Emery,Oliver FitzGerald,Philip S. Helliwell,Arthur Kavanaugh,Tore K Kvien,Robert Landewé,Thomas A. Luger,Philip J. Mease,Ignazio Olivieri,John D. Reveille,Christopher T. Ritchlin,Martin Rudwaleit,Monika Schoels,Joachim Sieper,Martinus de Wit,Xenofon Baraliakos,Neil Betteridge,Ruben Burgos-Vargas,Eduardo Collantes-Estevez,Atul Deodhar,Dirk Elewaut,Laure Gossec,Merryn Jongkees,Mara Maccarone,Kurt Redlich,Filip Van den Bosch,James Cheng-Chung Wei,Kevin L. Winthrop,Désirée van der Heijde +31 more
TL;DR: The task force defined the treatment target for SpA as remission or, alternatively, low disease activity, being aware that the evidence base is not strong and needs to be expanded by future research.
Journal ArticleDOI
The impact of tumor necrosis factor α inhibitors on radiographic progression in ankylosing spondylitis.
Nigil Haroon,Robert D. Inman,Thomas J. Learch,Michael H. Weisman,MinJae Lee,Mohammad H. Rahbar,Michael M. Ward,John D. Reveille,Lianne S. Gensler +8 more
TL;DR: Treatment with TNFα inhibitors appears to reduce radiographic progression in patients with ankylosing spondylitis, especially with early initiation and with longer duration of followup, and the protective effect of TNF α inhibitors was stronger after propensity score matching.
Journal ArticleDOI
Enthesitis: from pathophysiology to treatment
Georg Schett,Rik Lories,Maria Antonietta D'Agostino,Dirk Elewaut,Bruce Kirkham,Enrique R. Soriano,Dennis McGonagle +6 more
TL;DR: The role of biomechanics, prostaglandin E2-mediated vasodilation and the activation of innate immune cells in the initiation phase of enthesitis, as well as the role of entheseal IL-23-responsive cells that augment inflammation by producing pro-inflammatory mediators such as IL-17A, IL-22 and TNF are addressed.
Journal ArticleDOI
Continuous long-term anti-TNF therapy does not lead to an increase in the rate of new bone formation over 8 years in patients with ankylosing spondylitis
TL;DR: The radiographic progression of ankylosing spondylitis patients treated with infliximab versus historical controls never treated with tumour necrosis factor (TNF)-blockers over 8 years argues against a major role for the TNF-brake hypothesis.
References
More filters
Journal ArticleDOI
Evaluation of diagnostic criteria for ankylosing spondylitis. A proposal for modification of the New York criteria.
TL;DR: The study showed the clinical history screening test for AS to be moderately sensitive, but it might be better in clinical practice, and substitution of the Rome pain criterion for the New York pain criterion is proposed.
Journal ArticleDOI
The European spondylarthropathy study group preliminary criteria for the classification of spondylarthropathy
Maxime Dougados,van der Linden S,Juhlin R,Huitfeldt B,Bernard Amor,Andrei Calin,A. Cats,Ben A. C. Dijkmans,Ignazio Olivieri,Pasero G +9 more
TL;DR: The proposed classification criteria for spondylarthropathy are easy to apply in clinical practice and performed well in all 7 participating centers and are regarded as preliminary until they have been further evaluated in other settings.
Journal ArticleDOI
2010 update of the ASAS/EULAR recommendations for the management of ankylosing spondylitis
Jürgen Braun,R. van den Berg,Xenofon Baraliakos,H. Boehm,Ruben Burgos-Vargas,Eduardo Collantes-Estevez,B. Dijkmans,Paul Emery,Muhammad Asim Khan,Karel Pavelka +9 more
TL;DR: The ASAS/EULAR recommendations on the management of ankylo sing spondylitis (AS) are based on the original paper, a systematic review of existing recommendations and the literature since 2005 and the discussion and agreement among 21 international experts, 2 patients and 2 physiotherapists in a meeting in February 2010 as mentioned in this paper.
2010 Update of the ASAS/EULAR recommendations for the management of ankylosing spondylitis
Jürgen Braun,R. van den Berg,Xenofon Baraliakos,H. Boehm,Ruben Burgos-Vargas,Eduardo Collantes-Estevez,Hanne Dagfinrud,B. Dijkmans,Maxime Dougados,Paul Emery,P. Geher,Mohammed Hammoudeh,Robert D. Inman,Merryn Jongkees,Muhammad Asim Khan,Uta Kiltz,Tore K Kvien,Marjatta Leirisalo-Repo,Walter P. Maksymowych,I. Olivieri,Karel Pavelka,Joachim Sieper,Ewa Stanislawska-Biernat,D. Wendling,Salih Ozgocmen,C. Van Drogen,B.J. van Royen,D. van der Heijde +27 more
TL;DR: This first update of the ASAS/EULAR recommendations on the management of ankylosing spondylitis is based on the original paper, a systematic review of existing recommendations and the literature since 2005 and the discussion and agreement among 21 international experts, 2 patients and 2 physiotherapists in a meeting in February 2010.
Journal ArticleDOI
Cyclooxygenase-2 regulates mesenchymal cell differentiation into the osteoblast lineage and is critically involved in bone repair
Xinping Zhang,Edward M. Schwarz,Donald A. Young,J. Edward Puzas,Randy N. Rosier,Regis J. O'Keefe +5 more
TL;DR: It is demonstrated that COX-2 plays an essential role in both endochondral and intramembranous bone formation during skeletal repair and regulates the induction of cbfa1 and osterix to mediate normal skeletal repair.
Related Papers (5)
Evaluation of diagnostic criteria for ankylosing spondylitis. A proposal for modification of the New York criteria.
The development of Assessment of SpondyloArthritis international Society classification criteria for axial spondyloarthritis (part II): validation and final selection
Martin Rudwaleit,D. van der Heijde,Robert Landewé,Joachim Listing,Nurullah Akkoc,J Brandt,Jürgen Braun,C.T. Chou,Eduardo Collantes-Estevez,Maxime Dougados,Feng Huang,Jieruo Gu,Muhammad Asim Khan,Yesim Kirazli,Walter P. Maksymowych,Herman Mielants,Inge Juul Sørensen,Salih Ozgocmen,Euthalia Roussou,R. Valle-Oñate,Ulrich Weber,James Cheng-Chung Wei,Joachim Sieper +22 more