Effect of vitamin D deficiency and replacement on endothelial function in asymptomatic subjects.
Ozlem Tarcin,Dilek Gogas Yavuz,Beste Ozben,Ahu Telli,Ayliz Velioğlu Öğünç,Meral Yüksel,Ahmet Toprak,Dilek Yazici,Seda Sancak,Oguzhan Deyneli,Sema Akalin +10 more
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It is shown that 25(OH)D deficiency is associated with endothelial dysfunction and increased lipid peroxidation and may predispose to higher rates of cardiovascular disease in the winter.Abstract:
Context: Vitamin D receptors are present in many tissues. Hypovitaminosis D is considered to be a risk factor for atherosclerosis. Objective: This study explores the effects of vitamin D replacement on insulin sensitivity, endothelial function, inflammation, oxidative stress, and leptin in vitamin D-deficient subjects. Design, Setting, and Patients: Twenty-three asymptomatic vitamin D-deficient subjects with 25-hydroxyvitamin D [25(OH)D] levels below 25 nmol/liter were compared with a control group that had a mean 25(OH)D level of 75 nmol/liter. The vitamin D-deficient group received 300,000 IU im monthly for 3 months. The following parameters were evaluated before and after treatment: vitamin D metabolites, leptin, endothelial function by brachial artery flow mediated dilatation (FMD), insulin sensitivity index based on oral glucose tolerance test, and lipid peroxidation as measures of thiobarbituric acid reactive substances (TBARS). Results: FMD measurements were significantly lower in 25(OH)D-deficient...read more
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Vitamin D and Cardiovascular Disease
Paul Norman,Janet T. Powell +1 more
TL;DR: This review summarizes the clinical studies showing associations between vitamin D status and cardiovascular disease and the experimental studies that explore the mechanistic basis for these associations.
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Maternal vitamin D status and adverse pregnancy outcomes: a systematic review and meta-analysis
TL;DR: Low maternal vitamin D levels in pregnancy may be associated with an increased risk of preeclampsia, GDM, preterm birth and SGA.
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The link between obesity and low circulating 25-hydroxyvitamin D concentrations: considerations and implications.
TL;DR: Additional research is needed to elucidate the complex and multifaceted factors underlying the association between low circulating 25-hydroxyvitamin D and obesity, and to identify optimal treatment approaches in obese individuals and in bariatric surgical patients both before and after surgery.
Journal ArticleDOI
25-Hydroxyvitamin D deficiency is associated with inflammation-linked vascular endothelial dysfunction in middle-aged and older adults
TL;DR: Inadequate serum 25(OH)D is associated with vascular endothelial dysfunction among healthy middle-aged/older adults, and this is mediated in part by nuclear factor &kgr;B–related inflammation.
Journal ArticleDOI
Vitamin D Status Is Associated With Arterial Stiffness and Vascular Dysfunction in Healthy Humans
Ibhar Al Mheid,Riyaz S. Patel,Riyaz S. Patel,Jonathan R. Murrow,Alanna A. Morris,Ayaz Rahman,Lucy Fike,Nino Kavtaradze,Irina Uphoff,Craig Hooper,Vin Tangpricha,R. Wayne Alexander,Kenneth L. Brigham,Kenneth L. Brigham,Arshed A. Quyyumi +14 more
TL;DR: Vitamin D insufficiency is associated with increased arterial stiffness and endothelial dysfunction in the conductance and resistance blood vessels in humans, irrespective of traditional risk burden, and provides impetus for larger trials to assess the effects of vitamin D therapy in cardiovascular disease.
References
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TL;DR: State-of-the-art information is presented and insights are provided into the strengths and limitations of high-resolution ultrasonography of the brachial artery to evaluate vasomotor function, with guidelines for its research application in the study of endothelial physiology.
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Vitamin D Deficiency and Risk of Cardiovascular Disease
Thomas J. Wang,Michael J. Pencina,Sarah L. Booth,Paul F. Jacques,Erik Ingelsson,Katherine J. Lanier,Emelia J. Benjamin,Ralph B. D'Agostino,Myles Wolf,Ramachandran S. Vasan +9 more
TL;DR: Vitamin D deficiency is associated with incident cardiovascular disease and further clinical and experimental studies may be warranted to determine whether correction of vitamin D deficiency could contribute to the prevention of cardiovascular disease.
Journal ArticleDOI
Estimation of optimal serum concentrations of 25-hydroxyvitamin D for multiple health outcomes
Heike A. Bischoff-Ferrari,Edward Giovannucci,Walter C. Willett,Thomas Dietrich,Bess Dawson-Hughes +4 more
TL;DR: Evidence from studies that evaluated thresholds for serum 25(OH)D concentrations in relation to bone mineral density, lower-extremity function, dental health, and risk of falls, fractures, and colorectal cancer suggests that an increase in the currently recommended intake of vitamin D is warranted.
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Vitamin D: importance in the prevention of cancers, type 1 diabetes, heart disease, and osteoporosis
TL;DR: The role of vitamin D deficiency in increasing the risk of many common and serious diseases, including some common cancers, type 1 diabetes, cardiovascular disease, and osteoporosis is discussed in this article.