Journal ArticleDOI
Effects of acteoside on lipopolysaccharide-induced inflammation in acute lung injury via regulation of NF-κB pathway in vivo and in vitro
Wang Jing,Ma Chunhua,Wang Shumin +2 more
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The experimental results indicated that the protective mechanism of AC might be attributed partly to the inhibition of proinflammatory cytokine production and NF-κB activation.About:
This article is published in Toxicology and Applied Pharmacology.The article was published on 2015-06-01. It has received 180 citations till now. The article focuses on the topics: Lung injury & Proinflammatory cytokine.read more
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The protective effect of dexmedetomidine on LPS-induced acute lung injury through the HMGB1-mediated TLR4/NF-κB and PI3K/Akt/mTOR pathways.
TL;DR: It is shown that DEX exerted a protective effect on LPS‐induced ALI rats likely through the HMGB1‐mediated TLR4/NF‐&kgr;B and PI3K/Akt/mTOR pathways.
Journal ArticleDOI
The protective effect of Trillin LPS-induced acute lung injury by the regulations of inflammation and oxidative state.
Wenjiao Jiang,Fen Luo,Qianfeng Lu,Jingyan Liu,Peijin Li,Xiaofan Wang,Yeliu Fu,Kun Hao,Tianhua Yan,Xuansheng Ding +9 more
TL;DR: The results indicated that Tr exhibited protective effect on LPS-induced ALI by the regulations of related inflammatory events via the activations of Nrf2, HO-1 and NF-κB pathway and could be a potentially effective candidate medicine for the treatment of ALI.
Journal ArticleDOI
Protective effects of polydatin on lipopolysaccharide-induced acute lung injury through TLR4-MyD88-NF-κB pathway.
Qi Jiang,Min Yi,Qianqian Guo,Ciman Wang,Huimin Wang,Shanshan Meng,Chao Liu,Yeliu Fu,Hui Ji,Tong Chen +9 more
TL;DR: It is indicated that PD played a protective role in LPS-induced ALI and BEAS-2B cells and supported further study of PD as potential candidate for acute lung injury.
Journal ArticleDOI
Salidroside suppressing LPS-induced myocardial injury by inhibiting ROS-mediated PI3K/Akt/mTOR pathway in vitro and in vivo.
TL;DR: Sal exerts pronounced cardioprotective effect in rats subjected to LPS possibly through inhibiting the iNOS, COX‐2, NF‐κB and PI3K/Akt/mTOR pathway in vivo, and the results indicated that Sal could be a potential therapeutic agent for the treatment of cardiovascular disease.
Journal ArticleDOI
Natural product derived phytochemicals in managing acute lung injury by multiple mechanisms.
Yu-Qiong He,Can-Can Zhou,Lu-Yao Yu,Liang Wang,Jiu-Ling Deng,Yu-Long Tao,Feng Zhang,Feng Zhang,Wansheng Chen,Wansheng Chen +9 more
TL;DR: This review focuses on the potential therapeutic effects of natural compounds on ALI and the underlying mechanisms, and discusses 159 compounds and summarizes more than 400 references to present the protective effects ofnatural compounds against ALI.
References
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The acute respiratory distress syndrome
TL;DR: An overview of the definitions, clinical features, and epidemiology of the acute respiratory distress syndrome is provided and advances in the areas of pathogenesis, resolution, and treatment are discussed.
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Incidence and Outcomes of Acute Lung Injury
Gordon D. Rubenfeld,Ellen Caldwell,Eve Peabody,Jim Weaver,Diane P. Martin,Margaret J. Neff,Eric J. Stern,Leonard D. Hudson +7 more
TL;DR: It is estimated that each year in the United States there are 190,600 cases of acute lung injury, which are associated with 74,500 deaths and 3.6 million hospital days, considerably higher than previous reports have suggested.
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The value of the lipopolysaccharide-induced acute lung injury model in respiratory medicine
TL;DR: The goal of this article is to summarize and evaluate the results of experimental findings in LPS-induced ALI/ARDS, and the possible mechanisms and treatments elucidated, and disadvantages of such models in pulmonary research and new directions for future investigations are discussed.
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Epidemiology of acute lung injury.
TL;DR: Recent studies of the epidemiology of ALI have reported higher incidence rates for this syndrome than previously described, and the mortality and morbidity rates associated with ALI are considerable, with significant impact on public health.