Journal ArticleDOI
The protective effect of dexmedetomidine on LPS-induced acute lung injury through the HMGB1-mediated TLR4/NF-κB and PI3K/Akt/mTOR pathways.
TLDR
It is shown that DEX exerted a protective effect on LPS‐induced ALI rats likely through the HMGB1‐mediated TLR4/NF‐&kgr;B and PI3K/Akt/mTOR pathways.About:
This article is published in Molecular Immunology.The article was published on 2018-02-01. It has received 197 citations till now. The article focuses on the topics: Lung injury & Protein kinase B.read more
Citations
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Journal ArticleDOI
Extracellular HMGB1: a therapeutic target in severe pulmonary inflammation including COVID-19?
Ulf Andersson,William Ottestad,William Ottestad,Kevin J. Tracey,Kevin J. Tracey,Kevin J. Tracey +5 more
TL;DR: It is proposed that extracellular HMGB1 should be considered as a therapeutic target for COVID-19 because it is plausible that these complexes are specifically removed in the lungs revealed by a 40% reduction ofHMGB1 plasma levels in arterial versus venous blood.
Journal ArticleDOI
High-Mobility Group Box 1 (HMGB1) and Autophagy in Acute Lung Injury (ALI): A Review
TL;DR: An update is provided on the current status of the role of HMBG1 and autophagy in ALI and a potential target for blocking inflammatory pathways is identified.
Journal ArticleDOI
TLR4 promotes microglial pyroptosis via lncRNA-F630028O10Rik by activating PI3K/AKT pathway after spinal cord injury.
Shun Xu,Jin Wang,Jianyuan Jiang,Jian Song,Wei Zhu,Fan Zhang,Minghao Shao,Haocheng Xu,Xiaosheng Ma,Feizhou Lyu +9 more
TL;DR: The results showed that TLR4 was activated following SCI and promoted the expression of lncRNA-F630028O10Rik, which functioned as a ceRNA for miR-1231-5p/Col1a1 axis and enhanced microglial pyroptosis after SCI by activating the PI3K/AKT pathway.
Journal ArticleDOI
Dexmedetomidine Protects Against Lipopolysaccharide-Induced Acute Kidney Injury by Enhancing Autophagy Through Inhibition of the PI3K/AKT/mTOR Pathway.
TL;DR: A novel mechanism in which DEX protects against LPS-induced AKI is demonstrated, which results in the removal of damaged mitochondria and reduces oxidative stress and apoptosis in L PS- induced AKI through the α2-AR and inhibition of the PI3K/AKT/mTOR pathway.
Journal Article
Glycyrrhizic acid ameliorates LPS-induced acute lung injury by regulating autophagy through the PI3K/AKT/mTOR pathway.
Lihua Qu,Chao Chen,Wei He,Yangye Chen,Yi Li,Yi Wen,Sichun Zhou,Yiqun Jiang,Xiaoping Yang,Ran Zhang,Li Shen +10 more
TL;DR: It is indicated that GA inhibited the production of inflammatory factors in LPS-induced ALI by regulating the PI3K/AKT/mTOR pathway related autophagy, which may provide a novel therapeutic perspective of GA in ameliorating ALI.
References
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Journal ArticleDOI
Incidence and Outcomes of Acute Lung Injury
Gordon D. Rubenfeld,Ellen Caldwell,Eve Peabody,Jim Weaver,Diane P. Martin,Margaret J. Neff,Eric J. Stern,Leonard D. Hudson +7 more
TL;DR: It is estimated that each year in the United States there are 190,600 cases of acute lung injury, which are associated with 74,500 deaths and 3.6 million hospital days, considerably higher than previous reports have suggested.
Journal ArticleDOI
The Acute Respiratory Distress Syndrome: Pathogenesis and Treatment
TL;DR: There is no effective pharmacologic therapy, although cell-based therapy and other therapies currently being tested in clinical trials may provide novel treatments for ARDS.
Journal ArticleDOI
Synthetic Oleanane Triterpenoids: Multifunctional Drugs with a Broad Range of Applications for Prevention and Treatment of Chronic Disease
Karen T. Liby,Michael B. Sporn +1 more
TL;DR: In these interactions, the addition of SOs to reactive cysteine residues in specific molecular targets triggers biological activity, Ultimately, SOs are multifunctional drugs that regulate the activity of entire networks.
Journal ArticleDOI
Effects of acteoside on lipopolysaccharide-induced inflammation in acute lung injury via regulation of NF-κB pathway in vivo and in vitro
Wang Jing,Ma Chunhua,Wang Shumin +2 more
TL;DR: The experimental results indicated that the protective mechanism of AC might be attributed partly to the inhibition of proinflammatory cytokine production and NF-κB activation.
Journal ArticleDOI
The protective effect of Trillin LPS-induced acute lung injury by the regulations of inflammation and oxidative state.
Wenjiao Jiang,Fen Luo,Qianfeng Lu,Jingyan Liu,Peijin Li,Xiaofan Wang,Yeliu Fu,Kun Hao,Tianhua Yan,Xuansheng Ding +9 more
TL;DR: The results indicated that Tr exhibited protective effect on LPS-induced ALI by the regulations of related inflammatory events via the activations of Nrf2, HO-1 and NF-κB pathway and could be a potentially effective candidate medicine for the treatment of ALI.
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Effects of acteoside on lipopolysaccharide-induced inflammation in acute lung injury via regulation of NF-κB pathway in vivo and in vitro
Wang Jing,Ma Chunhua,Wang Shumin +2 more