Effects of chocolate, cocoa, and flavan-3-ols on cardiovascular health: a systematic review and meta-analysis of randomized trials
Lee Hooper,Colin D. Kay,Asmaa Abdelhamid,Paul A. Kroon,Jeffrey S Cohn,Eric B. Rimm,Aedin Cassidy +6 more
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TLDR
Chocolate or cocoa improved FMD regardless of the dose consumed, whereas doses >50 mg epicatechin/d resulted in greater effects on systolic and diastolic BP, and previously unreported promising effects on insulin and HOMA-IR were found.About:
This article is published in The American Journal of Clinical Nutrition.The article was published on 2012-03-01 and is currently open access. It has received 543 citations till now.read more
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Dietary and Policy Priorities for Cardiovascular Disease, Diabetes, and Obesity: A Comprehensive Review
TL;DR: This review considers the history, new evidence, controversies, and corresponding lessons for modern dietary and policy priorities for cardiovascular diseases, obesity, and diabetes mellitus, and identifies major identified themes.
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Benefits of polyphenols on gut microbiota and implications in human health.
Fernando Cardona,Cristina Andres-Lacueva,Sara Tulipani,Francisco J. Tinahones,María Isabel Queipo-Ortuño +4 more
TL;DR: This review focuses on the reciprocal interactions between the gut microbiota and polyphenols, the mechanisms of action and the consequences of these interactions on human health.
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The effects of polyphenols and other bioactives on human health
TL;DR: Although deficiencies in polyphenol intake do not result in specific deficiency diseases, adequate intake of polyphenols could confer health benefits, especially with regard to chronic diseases, because tea, cocoa, fruits, and berries, as well as vegetables, are rich inpolyphenols.
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Bioavailability, bioactivity and impact on health of dietary flavonoids and related compounds: an update
Ana Rodriguez-Mateos,David Vauzour,Christian G. Krueger,Dhanansayan Shanmuganayagam,Jess D. Reed,Luca Calani,Pedro Mena,Daniele Del Rio,Alan Crozier +8 more
TL;DR: Recent findings on the bioavailability and biological activity of (poly)phenols are summarized, focusing on the epidemiological and clinical evidence of beneficial effects of flavonoids and related compounds on urinary tract infections, cognitive function and age-related cognitive decline, cancer and cardiovascular disease.
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Resveratrol and clinical trials: the crossroad from in vitro studies to human evidence.
Joao Tomé-Carneiro,Mar Larrosa,Antonio González-Sarrías,Francisco A. Tomás-Barberán,María Teresa García-Conesa,Juan Carlos Espín +5 more
TL;DR: This review will focus on the currently available evidence regarding resveratrol’s effects on humans obtained from randomized clinical trials and provide a critical outlook for further research on this molecule that is evolving from a minor dietary compound to a possible multi-target therapeutic drug.
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Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement
TL;DR: Moher et al. as mentioned in this paper introduce PRISMA, an update of the QUOROM guidelines for reporting systematic reviews and meta-analyses, which is used in this paper.
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Preferred reporting items for systematic reviews and meta-analyses: the PRISMA Statement.
TL;DR: The QUOROM Statement (QUality Of Reporting Of Meta-analyses) as mentioned in this paper was developed to address the suboptimal reporting of systematic reviews and meta-analysis of randomized controlled trials.
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Measuring inconsistency in meta-analyses
TL;DR: A new quantity is developed, I 2, which the authors believe gives a better measure of the consistency between trials in a meta-analysis, which is susceptible to the number of trials included in the meta- analysis.
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Bias in meta-analysis detected by a simple, graphical test
TL;DR: Funnel plots, plots of the trials' effect estimates against sample size, are skewed and asymmetrical in the presence of publication bias and other biases Funnel plot asymmetry, measured by regression analysis, predicts discordance of results when meta-analyses are compared with single large trials.
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Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement
TL;DR: A structured summary is provided including, as applicable, background, objectives, data sources, study eligibility criteria, participants, interventions, study appraisal and synthesis methods, results, limitations, conclusions and implications of key findings.