Effects of crocin and zinc chloride on blood levels of zinc and metabolic and oxidative parameters in streptozotocin-induced diabetic rats.
Siamak Asri-Rezaei,Esmaeal Tamaddonfard,Behnaz Gasemsoltani-Momtaz,Amir Erfanparast,Sima Gholamalipour +4 more
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Results indicated that separate and combined treatments with crocin and zinc chloride produced improving effects on the blood levels of zinc, glucose, insulin, MDA and TAC in STZ-induced diabetic rats.Abstract:
Objectives:Crocin is one of constituents of saffron and has antioxidant property. Zinc chloride is one of the common compounds of zinc with antioxidant activity. The present study was aimed to investigate separate and combined treatment effects of crocin and zinc chloride on blood levels of zinc and metabolic and oxidative parameters in diabetic rats. Materials and Methods:Diabetes was induced by intraperitoneal (i.p.) injection of 50 mg/kg of streptozotocin (STZ) and was confirmed by blood glucose levels higher than 250 mg/dL. After confirmation of diabetes, injections (i.p.) of crocin and zinc chloride were performed for six weeks. At the end of the experiment, blood levels of zinc, glucose, insulin, malodialdehyde (MDA), and total antioxidant capacity (TAC) were measured. Results:Crocin (25 and 50 mg/kg) and zinc chloride (5 mg/kg) significantly recovered the decreased levels of zinc, insulin, and TAC and improved the increased levels of glucose and MDA in STZ-induced diabetic rats. In a combination treatment performed with an ineffective dose of crocin (12.5 mg/kg) and a low dose of zinc chloride (1.25 mg/kg), improving effects were observed on the above-mentioned biochemical parameters. Conclusions: The results indicated that separate and combined treatments with crocin and zinc chloride produced improving effects on the blood levels of zinc, glucose, insulin, MDA and TAC in STZ-induced diabetic rats.read more
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Saffron: a promising natural medicine in the treatment of metabolic syndrome.
TL;DR: It is suggested that after randomised clinical trials, saffron may be implicated as a preventive or therapeutic agent against metabolic syndrome.
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Protective effects of crocin and zinc sulfate on hepatic ischemia-reperfusion injury in rats: a comparative experimental model study.
TL;DR: This study demonstrated that Cr, ZnSO4 and their combination through increasing antioxidant activity and Nrf2 expression, decreasing the serum levels of liver enzymes, miR-122, 34a, p53 expression, and amelioration of histopathological changes, protected liver against IR-induced injury.
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Histopathological and behavioral evaluations of the effects of crocin, safranal and insulin on diabetic peripheral neuropathy in rats
TL;DR: Crocin, safranal and insulin improved STZ-induced behavioral, histopathological and biochemical changes and enhanced the neuroprotective effect of insulin in a rat model of diabetic neuropathy.
Journal ArticleDOI
Protective effect of crocin and voluntary exercise against oxidative stress in the heart of high-fat diet-induced type 2 diabetic rats.
Ghorbanzadeh,Mustafa Mohammadi,Gisou Mohaddes,Hassan Dariushnejad,Leila Chodari,Shima Mohammadi +5 more
TL;DR: It is suggested that a combination of crocin with voluntary exercise treatment may cause more beneficial effects in antioxidant defense system of heart tissues than the use of croin or voluntary exercise alone.
Journal ArticleDOI
The effects of crocin, insulin and their co-administration on the heart function and pathology in streptozotocin-induced diabetic rats.
TL;DR: The results showed cardioprotective effects of crocin and insulin in STZ-induced diabetic rats, suggesting the antioxidant and anti-hyperglycemic properties of croin and insulin may be involved in their cardioprotsective actions.
References
More filters
Journal ArticleDOI
The ferric reducing ability of plasma (FRAP) as a measure of 'antioxidant power' : the FRAP assay
TL;DR: The FRAP assay offers a putative index of antioxidant, or reducing, potential of biological fluids within the technological reach of every laboratory and researcher interested in oxidative stress and its effects.
Journal ArticleDOI
Global Prevalence of Diabetes: Estimates for the year 2000 and projections for 2030
TL;DR: Findings indicate that the "diabetes epidemic" will continue even if levels of obesity remain constant, and given the increasing prevalence of obesity, it is likely that these figures provide an underestimate of future diabetes prevalence.
Journal Article
The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas.
TL;DR: The cytotoxic action of both these diabetogenic agents is mediated by reactive oxygen species, however, the source of their generation is different in the case of alloxan and streptozotocin.
Journal ArticleDOI
The biochemical basis of zinc physiology
TL;DR: Majors topics addressed in this review on zinc physiology are chemistry and biochemistry; interface of biochemistry and physiology of zinc; physiology and cell and molecular biology; and pathology.
Book ChapterDOI
Assay for blood plasma or serum.
TL;DR: It was anticipated that platelet aggregation, if it occurs during the drawing of the blood, would liberate the TBA-reacting substances, and the effect of the aggregation was found to be eliminated by treatment with phosphotungstic acid–sulfuric acid system.