Effects of early life stress on cognitive and affective function: an integrated review of human literature.
Pia Pechtel,Diego A. Pizzagalli +1 more
TLDR
Higher-order, complex cognitive and affective functions associated with brain regions undergoing protracted postnatal development are particularly vulnerable to the deleterious effects of ELS, and the amygdala is particularly sensitive to early ELS.Abstract:
Rationale
The investigation of putative effects of early life stress (ELS) in humans on later behavior and neurobiology is a fast developing field. While epidemiological and neurobiological studies paint a somber picture of negative outcomes, relatively little attention has been devoted to integrating the breadth of findings concerning possible cognitive and emotional deficits associated with ELS. Emerging findings from longitudinal studies examining developmental trajectories of the brain in healthy samples may provide a new framework to understand mechanisms underlying ELS sequelae.read more
Citations
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The effect of multiple adverse childhood experiences on health: a systematic review and meta-analysis
Karen Hughes,Mark A Bellis,Katherine A. Hardcastle,Dinesh Sethi,Alexander Butchart,Christopher Mikton,Lisa Jones,Michael P. Dunne +7 more
TL;DR: In this paper, a systematic review and meta-analysis was conducted to identify the harmful effects that adverse childhood experiences (ACEs; occurring during childhood or adolescence; eg, child maltreatment or exposure to domestic violence) have on health throughout life.
Journal ArticleDOI
Depression, stress, and anhedonia: toward a synthesis and integrated model.
TL;DR: A heuristic model is presented postulating that anhedonia arises from dysfunctional interactions between stress and brain reward systems, and a synthesis of these four literatures is provided.
Journal ArticleDOI
Neuroimaging of child abuse: a critical review
Heledd Hart,Katya Rubia +1 more
TL;DR: The better controlled studies that show a direct correlation between childhood abuse and brain measures suggest that the most prominent deficits associated with early childhood abuse are in the function and structure of lateral and ventromedial fronto-limbic brain areas and networks that mediate behavioral and affect control.
Journal ArticleDOI
Behavioral Problems After Early Life Stress: Contributions of the Hippocampus and Amygdala
Jamie L. Hanson,Brendon M. Nacewicz,Matthew J. Sutterer,Amelia A. Cayo,Stacey M. Schaefer,Karen D. Rudolph,Elizabeth A. Shirtcliff,Seth D. Pollak,Richard J. Davidson +8 more
TL;DR: This study suggests ELS may shape the development of brain areas involved with emotion processing and regulation in similar ways, and differences in the amygdala and hippocampus may be a shared diathesis for later negative outcomes related to ELS.
Journal ArticleDOI
More than a feeling: A unified view of stress measurement for population science.
Elissa S. Epel,Alexandra D. Crosswell,Stefanie E. Mayer,Aric A. Prather,George M. Slavich,Eli Puterman,Wendy Berry Mendes +6 more
TL;DR: An integrative working model is articulated, highlighting how stressor exposures across the life course influence habitual responding and stress reactivity, and how health behaviors interact with stress, and a Stress Typology articulating timescales for stress measurement is offered.
References
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Journal ArticleDOI
Brain development during childhood and adolescence: a longitudinal MRI study.
Jay N. Giedd,Jonathan D. Blumenthal,Neal Jeffries,F X Castellanos,Hong Liu,Alex P. Zijdenbos,Tomáš Paus,Alan C. Evans,Judith L. Rapoport +8 more
TL;DR: This large-scale longitudinal pediatric neuroimaging study confirmed linear increases in white matter, but demonstrated nonlinear changes in cortical gray matter, with a preadolescent increase followed by a postadolescent decrease.
Journal ArticleDOI
Dynamic mapping of human cortical development during childhood through early adulthood
Nitin Gogtay,Jay N. Giedd,Leslie Lusk,Kiralee M. Hayashi,Deanna Greenstein,A. Catherine Vaituzis,Tom F. Nugent,David H. Herman,Liv S. Clasen,Arthur W. Toga,Judith L. Rapoport,Paul M. Thompson +11 more
TL;DR: The dynamic anatomical sequence of human cortical gray matter development between the age of 4-21 years using quantitative four-dimensional maps and time-lapse sequences reveals that higher-order association cortices mature only after lower-order somatosensory and visual cortices are developed.
Journal ArticleDOI
Effects of stress throughout the lifespan on the brain, behaviour and cognition
TL;DR: In this Review a model is developed to explain why different disorders emerge in individuals exposed to stress at different times in their lives.
Journal ArticleDOI
The cognitive control of emotion.
Kevin N. Ochsner,James J. Gross +1 more
TL;DR: The results suggest a functional architecture for the cognitive control of emotion that dovetails with findings from other human and nonhuman research on emotion.
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The enduring effects of abuse and related adverse experiences in childhood: A convergence of evidence from neurobiology and epidemiology
Robert F. Anda,Vincent J. Felitti,J. Douglas Bremner,John D Walker,Charles L. Whitfield,Bruce D Perry,Shanta R. Dube,Wayne H. Giles +7 more
TL;DR: The graded relationship of the ACE score to 18 different outcomes in multiple domains theoretically parallels the cumulative exposure of the developing brain to the stress response with resulting impairment in multiple brain structures and functions.