Journal ArticleDOI
Effects of stress throughout the lifespan on the brain, behaviour and cognition
TLDR
In this Review a model is developed to explain why different disorders emerge in individuals exposed to stress at different times in their lives.Abstract:
Chronic exposure to stress hormones, whether it occurs during the prenatal period, infancy, childhood, adolescence, adulthood or aging, has an impact on brain structures involved in cognition and mental health. However, the specific effects on the brain, behaviour and cognition emerge as a function of the timing and the duration of the exposure, and some also depend on the interaction between gene effects and previous exposure to environmental adversity. Advances in animal and human studies have made it possible to synthesize these findings, and in this Review a model is developed to explain why different disorders emerge in individuals exposed to stress at different times in their lives.read more
Citations
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Journal ArticleDOI
Stress signalling pathways that impair prefrontal cortex structure and function
TL;DR: Recent research has provided clues as to why genetic or environmental insults that disinhibit stress signalling pathways can lead to symptoms of profound prefrontal cortical dysfunction in mental illness.
Journal ArticleDOI
Allostatic load biomarkers of chronic stress and impact on health and cognition.
TL;DR: This article reviews theoretical and empirical work using the allostatic load model vis-à-vis the effects of chronic stress on physical and mental health and proposes policies for promoting successful aging.
Journal ArticleDOI
Psychological Stress in Childhood and Susceptibility to the Chronic Diseases of Aging: Moving toward a Model of Behavioral and Biological Mechanisms.
TL;DR: A biological embedding model is presented that maintains that childhood stress gets "programmed" into macrophages through epigenetic markings, posttranslational modifications, and tissue remodeling, and proposes that over the life course, these proinflammatory tendencies are exacerbated by behavioral proclivities and hormonal dysregulation, themselves the products of exposure to early stress.
Journal ArticleDOI
Differential susceptibility to the environment: an evolutionary--neurodevelopmental theory.
Bruce J. Ellis,W. Thomas Boyce,Jay Belsky,Marian J. Bakermans-Kranenburg,Marinus H. van IJzendoorn +4 more
TL;DR: The differential susceptibility paradigm has far-reaching implications for understanding whether and how much child and adult development responds, for better and for worse, to the gamut of species-typical environmental conditions.
Journal ArticleDOI
Serotonin, tryptophan metabolism and the brain-gut-microbiome axis.
TL;DR: Therapeutic targeting of the gut microbiota might be a viable treatment strategy for serotonin-related brain-gut axis disorders.
References
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Journal ArticleDOI
Meta-Analysis: A Constantly Evolving Research Integration Tool
TL;DR: The four articles in this special section onMeta-analysis illustrate some of the complexities entailed in meta-analysis methods and contributes both to advancing this methodology and to the increasing complexities that can befuddle researchers.
Journal ArticleDOI
Epigenetic programming by maternal behavior.
Ian C. G. Weaver,Nadia Cervoni,Frances A. Champagne,Ana C. D'Alessio,Shakti Sharma,Jonathan R. Seckl,Sergiy Dymov,Moshe Szyf,Michael J. Meaney +8 more
TL;DR: It is shown that an epigenomic state of a gene can be established through behavioral programming, and it is potentially reversible, suggesting a causal relation among epigenomicState, GR expression and the maternal effect on stress responses in the offspring.
Book
The Emotional Brain: The Mysterious Underpinnings of Emotional Life
TL;DR: The Emotional Brain this article investigates the origins of human emotions and explains that many exist as part of complex neural systems that evolved to enable us to survive, and this may be the key to understanding, even changing, our emotional makeup.
Journal ArticleDOI
Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse
Patrick O. McGowan,Aya Sasaki,Aya Sasaki,Ana C. D'Alessio,Sergiy Dymov,Benoit Labonté,Moshe Szyf,Gustavo Turecki,Michael J. Meaney,Michael J. Meaney +9 more
TL;DR: Findings translate previous results from rat to humans and suggest a common effect of parental care on the epigenetic regulation of hippocampal glucocorticoid receptor expression.
Journal ArticleDOI
Maternal Care, Hippocampal Glucocorticoid Receptors, and Hypothalamic-Pituitary-Adrenal Responses to Stress
Dong Liu,Josie Diorio,Josie Diorio,Beth Tannenbaum,Beth Tannenbaum,Christian Caldji,Christian Caldji,Darlene D. Francis,Darlene D. Francis,Alison Freedman,Alison Freedman,Shakti Sharma,Shakti Sharma,Deborah Pearson,Deborah Pearson,Paul M. Plotsky,Paul M. Plotsky,Michael J. Meaney,Michael J. Meaney +18 more
TL;DR: It is suggested that maternal behavior serves to "program" hypothalamic-pituitary-adrenal responses to stress in the offspring.