Journal ArticleDOI
Effects of losartan or atenolol in hypertensive patients without clinically evident vascular disease: a substudy of the LIFE randomized trial.
Richard B. Devereux,Bjrn Dahlf,Sverre E. Kjeldsen,Stevo Julius,Peter Aurup,Gareth Beevers,Jonathan M. Edelman,Ulf de Faire,Frej Fyhrquist,Sigrid Helle Berg,Hans Ibsen,Krister Kristianson,Ole Lederballe-Pedersen,Lars H Lindholm,Markku S. Nieminen,Per Omvik,Suzanne Oparil,Steven M. Snapinn,Hans Wedel +18 more
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TLDR
A subgroup analysis in the LIFE study was performed to determine whether angiotensin II AT1-receptor antagonism with losartan reduces cardiovascular morbidity and mortality, compared with active therapy with established -blockerbased therapy, in hypertensive participants with electrocardiogram-defined LVH.Abstract:
In hypertensive patients without clinically evident vascular disease, losartan and atenolol were equally effective in reducing blood pressure, but losartan was more effective in preventing cardiova...read more
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Factors Influencing the Decline in Stroke Mortality A Statement From the American Heart Association/American Stroke Association
Daniel T. Lackland,Edward J. Roccella,Anne Deutsch,Myriam Fornage,Mary G. George,George Howard,Brett M. Kissela,Steven J. Kittner,Judith H. Lichtman,Lynda D. Lisabeth,Lee H. Schwamm,Eric E. Smith,Amytis Towfighi +12 more
TL;DR: There is strong evidence that the decline in stroke mortality can be attributed to a combination of interventions and programs based on scientific findings and implemented with the purpose of reducing stroke risks, the most likely being improved control of hypertension.
Journal ArticleDOI
Improved islet morphology after blockade of the renin-angiotensin system in the ZDF rat
Chris Tikellis,Peter J. Wookey,Riccardo Candido,Sofianos Andrikopoulos,Sofianos Andrikopoulos,Merlin C. Thomas,Mark E. Cooper +6 more
TL;DR: Improvements in structural parameters were also associated with functional improvements in first-phase insulin secretion and provide a possible mechanism for the reduced incidence of new-onset diabetes that has been observed in clinical trials of RAS blockade.
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Morbidity and mortality in the Swedish trial in old patients with hypertension (STOP-hypertension). Commentary
Journal ArticleDOI
Increased expression of NAD(P)H oxidase in islets of animal models of Type 2 diabetes and its improvement by an AT1 receptor antagonist.
Mieko Nakayama,Toyoshi Inoguchi,Toshiyo Sonta,Yasutaka Maeda,Shuji Sasaki,Fumi Sawada,Hirotaka Tsubouchi,Noriyuki Sonoda,Kunihisa Kobayashi,Hideki Sumimoto,Hajime Nawata +10 more
TL;DR: Immunostaining analysis showed that staining intensities of NAD(P)H oxidase components, gp91phox and p22phox, significantly increased in islets of animal models of Type 2 diabetes, OLETF rats and db/db mice, compared with age-matched controls, correlating with increased levels of oxidative stress marker.
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Chronic Management of Blood Pressure After Stroke
Laura Pedelty,Philip B. Gorelick +1 more
TL;DR: A 70-year-old, right-handed African American woman with diabetes mellitus, treated with an oral hypoglycemic, and untreated mild hypertension developed right-sided face, arm, and leg weakness while at home preparing breakfast.
References
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Journal ArticleDOI
Effects of an angiotensin-converting -enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients
TL;DR: Ramipril significantly reduces the rates of death, myocardial infarction, and stroke in a broad range of high-risk patients who are not known to have a low ejection fraction or heart failure.
Journal ArticleDOI
Cardiovascular morbidity and mortality in the Losartan Intervention For Endpoint reduction in hypertension study (LIFE): a randomised trial against atenolol.
Björn Dahlöf,Richard B. Devereux,Sverre E. Kjeldsen,Stevo Julius,Gareth Beevers,Ulf de Faire,Frej Fyhrquist,Hans Ibsen,Krister Kristiansson,Ole Lederballe-Pedersen,Lars H Lindholm,Markku S. Nieminen,Per Omvik,Suzanne Oparil,Hans Wedel +14 more
TL;DR: Losartan prevents more cardiovascular morbidity and death than atenolol for a similar reduction in blood pressure and is better tolerated, while new-onset diabetes was less frequent with losartan.
Journal ArticleDOI
Effect of angiotensin-converting-enzyme inhibition compared with conventional therapy on cardiovascular morbidity and mortality in hypertension: the Captopril Prevention Project (CAPPP) randomised trial
Lennart Hansson,Lars H Lindholm,Leo Niskanen,Jan Lanke,Thomas Hedner,Anders Niklason,Kimmo Luomanmäki,Björn Dahlöf,Ulf de Faire,Claes Mörlin,Bengt E. Karlberg,P. O. Wester,Jan-Erik Björck +12 more
TL;DR: Captopril and conventional treatment did not differ in efficacy in preventing cardiovascular morbidity and mortality and the difference in stroke risk was probably due to the lower levels of blood pressure obtained initially in previously treated patients randomised to conventional therapy.
Journal ArticleDOI
An updated coronary risk profile. A statement for health professionals.
TL;DR: Using a simple worksheet, a patient's 5- and 10-year CHD risks can be estimated using components of the profile selected because they are objective and strongly and independently related to CHD.
Journal ArticleDOI
Effects of ACE inhibitors, calcium antagonists, and other blood-pressure-lowering drugs: results of prospectively designed overviews of randomised trials. Blood Pressure Lowering Treatment Trialists' Collaboration
TL;DR: Strong evidence of benefits of ACE inhibitors and calcium antagonists is provided by the overviews of placebo-controlled trials, and data from continuing trials of blood-pressure-lowering drugs will substantially increase the evidence available about any real differences that might exist between regimens.
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