Effects of Metallic and Carbon-Based Nanomaterials on Human Pancreatic Cancer Cell Lines AsPC-1 and BxPC-3.
Barbara Wójcik,Ewa Sawosz,Jarosław Szczepaniak,Barbara Strojny,Malwina Sosnowska,Karolina Daniluk,Marlena Zielińska-Górska,Jaśmina Bałaban,André Chwalibog,Mateusz Wierzbicki +9 more
TLDR
In this article, the authors evaluated the toxicity of nanomaterials against human pancreatic adenocarcinoma cell lines and found that the highest cytotoxicity was obtained after the diamond treatment.Abstract:
Pancreatic cancer, due to its asymptomatic development and drug-resistance, is difficult to cure. As many metallic and carbon-based nanomaterials have shown anticancer properties, we decided to investigate their potential use as anticancer agents against human pancreatic adenocarcinoma. The objective of the study was to evaluate the toxic properties of the following nanomaterials: silver (Ag), gold (Au), platinum (Pt), graphene oxide (GO), diamond (ND), and fullerenol (C60(OH)40) against the cell lines BxPC-3, AsPC-1, HFFF-2, and HS-5. The potential cytotoxic properties were evaluated by the assessment of the cell morphology, cell viability, and cell membrane damage. The cancer cell responses to GO and ND were analysed by determination of changes in the levels of 40 different pro-inflammatory proteins. Our studies revealed that the highest cytotoxicity was obtained after the ND treatment. Moreover, BxPC-3 cells were more sensitive to ND than AsPC-1 cells due to the ND-induced ROS production. Furthermore, in both of the cancer cell lines, ND caused an increased level of IL-8 and a decreased level of TIMP-2, whereas GO caused only decreased levels of TIMP-2 and ICAM-1 proteins. This work provides important data on the toxicity of various nanoparticles against pancreatic adenocarcinoma cell lines.read more
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Ewing Sarcoma Meets Epigenetics, Immunology and Nanomedicine: Moving Forward into Novel Therapeutic Strategies
Sara Sanchez-Molina,Elisabet Figuerola-Bou,Víctor Sánchez-Margalet,L. De La Cruz Merino,Jaume Mora,E. de Álava Casado,Daniel J. García-Domínguez,Lourdes Hontecillas-Prieto +7 more
TL;DR: In this article , the authors provide a comprehensive overview of emerging therapeutic strategies and summarize the potential of the latest preclinical and clinical trials in Ewing sarcoma research, and underline the value and future directions of these new treatments.
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Design, Characterization and in vitro Simulations of nano-HAP/GO Composite Drug Delivery System Produced by Hydrothermal Methods Loaded with Paclitaxel
TL;DR: In this paper , a nano drug system that can be used in passive targeting in pancreatic cancer treatment was developed. But, it was only used for passive targeting, and the results showed that the drug release profile was observed according to the Hixson model.
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