Journal ArticleDOI
Effects of surface properties on fluid engineering generated by the surface-driven capillary flow of water in microfluidic lab-on-a-chip systems for bioengineering applications
Subhadeep Mukhopadhyay,Jyoti Prasad Banerjee,Susanta Sinha Roy,Sanjeev Kumar Metya,Mark Tweedie,James McLaughlin +5 more
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In this paper, the effect of bend angle as channel geometry to control the surface-driven capillary flow is investigated as a novel approach to control separation time in microfluidic lab-on-a-chip systems.Abstract:
In this research paper, in total 212 individual leakage-free Polymethylmethacrylate (PMMA) microfluidic devices are fabricated by maskless lithography, hot embossing lithography and direct bonding technique. The effect of channel aspect ratio on dyed water flow is investigated using these microfluidic devices. Experimental studies show that the dyed water flow is faster on the surface of higher wettability. The effect of capillary pressure on dyed water flow is studied in the fabricated PMMA microfluidic devices. According to the experimental observations, the centrifugal force has prominent effect on the dyed water flow. Also, the effect of bend angle is investigated on the surface-driven capillary flow of water. The polystyrene microparticles have been separated in the microfluidic lab-on-a-chip systems using the investigated flow features. A 100% separation efficiency is achieved in these lab-on-a-chip systems. These microfluidic lab-on-a-chip systems can be used to separate blood cells from human whole blood for further clinical tests. These experimental studies are important in bioengineering applications. The effect of bend angle as channel geometry to control the surface-driven capillary flow is investigated as a novel approach to control the separation time in microfluidic lab-on-a-chip systems. Also, the effect of surface wettability as surface property to control the surface-driven capillary flow is investigated as a novel approach to control the separation time in microfluidic lab-on-a-chip systems.read more
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Continuous Separation of Microparticles in a Microfluidic Channel via the Elasto-inertial Effect of Non-Newtonian Fluid
TL;DR: Conclusively, the microparticle separation technique using elasto-inertial forces in non-Newtonian fluid is an effective method for separating and collecting microparticles on the basis of size differences with high purity.
Journal ArticleDOI
Advances in passively driven microfluidics and lab-on-chip devices: a comprehensive literature review and patent analysis
Vigneswaran Narayanamurthy,Vigneswaran Narayanamurthy,Z. E. Jeroish,Z. E. Jeroish,K. S. Bhuvaneshwari,K. S. Bhuvaneshwari,Pouriya Bayat,R. Premkumar,Fahmi Samsuri,Mashitah M. Yusoff +9 more
TL;DR: A comprehensive review, along with patent analysis, is presented here, listing the latest advances in passive microfluidic techniques,Along with the related mechanisms and applications.
Journal ArticleDOI
Experimental investigations on the surface-driven capillary flow of aqueous microparticle suspensions in the microfluidic laboratory-on-a-chip systems
TL;DR: In this paper, the surface-driven microfluidic flow of aqueous microparticle suspensions with the investigations on the separation time in particle-size based separation mechanism to control these suspensions in the micro fluididic lab-on-a-chip systems.
Journal ArticleDOI
Experimental investigations on the interactions between liquids and structures to passively control the surface-driven capillary flow in microfluidic lab-on-a-chip systems to separate the microparticles for bioengineering applications
TL;DR: In this article, the effect of surface area to volume ratio on the surface-driven capillary flow of different liquids has been experimentally investigated in these microfluidic devices fabricated by polymethylmethacrylate (PMMA).
Aspects of Diamond-Like Carbon based MEMS and Microfluidic Devices
TL;DR: In this paper, the diamond-like carbon (DLC) is used in the fabrication of micro electromechanical systems (MEMS) and microfluidic devices and different features of DLC are briefly highlighted.
References
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Electrowetting: from basics to applications
TL;DR: In this paper, the authors compare the various approaches used to derive the basic electrowetting equation, which has been shown to be very reliable as long as the applied voltage is not too high.
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Polymer microfluidic devices
Holger Becker,Laurie E. Locascio +1 more
TL;DR: This article presents a review of polymer-based microfluidic systems including their material properties, fabrication methods, device applications, and finally an analysis of the market that drives their development.
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Review Article—Dielectrophoresis: Status of the theory, technology, and applications
TL;DR: Current trends suggest that the theory and technology have matured sufficiently for most effort to now be directed towards applying DEP to unmet needs in such areas as biosensors, cell therapeutics, drug discovery, medical diagnostics, microfluidics, nanoassembly, and particle filtration.
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Studies on surface wettability of poly(dimethyl) siloxane (PDMS) and glass under oxygen-plasma treatment and correlation with bond strength
TL;DR: In this article, the authors explored the possibility of the existence of a common scale, which can be used to gauge bond strength between various surfaces and found that the changes in wettability of surfaces owing to various levels of plasma exposure can be a useful parameter to gauge the bond strength.
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Chip integrated strategies for acoustic separation and manipulation of cells and particles
TL;DR: This tutorial review outlines the fundamental work performed on continuous flow acoustic standing wave separation of particles in macro scale systems and discusses several potential applications in life science research and in the medical clinic.