Journal ArticleDOI
Efficient photosensitization of malignant human cells in vitro by liposome-bound porphyrins
I Cozzani,Giulio Jori,Giulio Bertoloni,Carla Milanesi,Paola Carlini,Tiziana Sicuro,Antonia Ruschi +6 more
TLDR
Electron microscopy investigations on cell damages caused by loading with liposome-bound porphyrins and subsequent illumination show that the plasmatic membrane is one important cell site of p Morphyrin interaction and photodynamic effect.About:
This article is published in Chemico-Biological Interactions.The article was published on 1985-01-01. It has received 33 citations till now. The article focuses on the topics: Porphyrin & Hematoporphyrin.read more
Citations
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Journal ArticleDOI
Photodynamic therapy - mechanisms, photosensitizers and combinations.
Stanisław Kwiatkowski,Bartosz Knap,Dawid Przystupski,Jolanta Saczko,Ewa Kędzierska,Karolina Knap-Czop,Jolanta Kotlinska,Olga Michel,Krzysztof Kotowski,Julita Kulbacka +9 more
TL;DR: The object of this review is the anticancer application of PDT, its advantages and possible modifications to potentiate its effects, and the use of nanoparticles enables achievement a targeted method which is focused on specific receptors, and, as a result, increases the selectivity of the photodynamic therapy.
Journal ArticleDOI
Liposomal delivery of photosensitising agents
TL;DR: Progress in the use of liposomal photosensitisers is covered, currentliposomal formulations are summarised, and future directions for the liposome delivery of photosensitising agents are project.
Journal ArticleDOI
Spectrofluorimetric study of porphyrin incorporation into membrane models - evidence for pH effects
TL;DR: The effects of hydrophobicity and charges of dicarboxylic porphyrins upon their interactions with membrane model systems are investigated and the hypothesis of a possible role of pH in the preferential uptake of p Morphyrins by tumors is discussed.
Journal ArticleDOI
Controlled targeting of different subcellular sites by porphyrins in tumour-bearing mice.
TL;DR: Intraperitoneal injection of the liposome-bound porphyrins to mice bearing a MS-2 fibrosarcoma results in remarkably more efficient tumour targeting than that obtained by administration of the same porphyrs dissolved in homogeneous aqueous solution.
Journal ArticleDOI
An insight on the role of photosensitizer nanocarriers for Photodynamic Therapy
Mariana Q. Mesquita,Cristina J. Dias,Sara R.D. Gamelas,Margarida Fardilha,Maria G. P. M. S. Neves,Maria A. F. Faustino +5 more
TL;DR: In this review a special attention will be given to the role of some drug delivery systems to improve the efficiency of tetrapyrrolic photosensitizers to this type of treatment.
References
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Journal ArticleDOI
THE USE OF LEAD CITRATE AT HIGH pH AS AN ELECTRON-OPAQUE STAIN IN ELECTRON MICROSCOPY
TL;DR: The stain reported here differs from previous alkaline lead stains in that the chelating agent, citrate, is in sufficient excess to sequester all lead present, and is less likely to contaminate sections.
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The mechanism of photodynamic inactivation of human cells in vitro in the presence of haematoporphyrin
TL;DR: Two findings indicate that the photoinduced damage is repairable: firstly, the fraction of cells surviving a given light dose decreases with decreasing irradiation temperature, and secondly, the survival curves have a shoulder at low exposures of light.
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A reliable and easily sectioned epoxy embedding medium.
W. R. Lockwood,L. L. Langston +1 more
TL;DR: The sections were strong enough to withstand intense electron beams on bare 150 mesh copper grids, and the inherent contrast was good without staining, but additional contrast was obtained by brief treatment with aqueous solutions of lead or uranyl salts.
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General observations on the ingrowth of new blood vessels into standardized chambers in the rabbit's ear, and the subsequent changes in the newly grown vessels over a period of months
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Preferential delivery of liposome-incorporated porphyrins to neoplastic cells in tumour-bearing rats.
TL;DR: Preferential delivery of liposome-incorporated porphyrins to neoplastic cells in tumour-bearing rats is shown to be preferential and beneficial in both the stationary and the moving parts of the immune system.