Journal ArticleDOI
Eight-membered ring templates for stereoselective radical cyclizations
TLDR
The ratio of cyclization to reduction of the cyclodec-6-enylmethyl radical depends critically on the alkene geometry as mentioned in this paper, which is a structural feature of the taxane diterpenes.About:
This article is published in Tetrahedron Letters.The article was published on 1988-01-01. It has received 16 citations till now. The article focuses on the topics: Radical cyclization.read more
Citations
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Journal ArticleDOI
Chemistry and Biology of Taxol
TL;DR: This account attempts to bring together in a cogent overview the chemistry and biology of taxol, one of the few organic compounds, which, like benzene and aspirin, is recognizable by name to the average citizen.
Journal ArticleDOI
The synthesis of carbocyclic eight-membered rings
Journal ArticleDOI
Free radicals in the synthesis of medium-sized rings
TL;DR: In this paper, free radical chemistry in the synthesis of seven-to-nine-membered rings is presented, and applications of free radical chemiques in the synthesisation of seven to nine-memered rings are discussed.
Journal ArticleDOI
Chemie und Biologie von Taxol
TL;DR: Taxus brevifolia, e.g., polyoxygeniertes Diterpen aus der Pazifischen Eibe, wurde in den spaten sechziger Jahren bei einer umfassenden Untersuchung pflanzlicher Stoffe auf antineoplastische Wirkstoffe entdeckt, an which es scheint, das die Medien aufmerksam geworden sind and jede neue Entwicklung gespannt er
Reference EntryDOI
Radical Cyclization Reactions
TL;DR: Radical cyclization reactions are among the most powerful and versatile methods for the construction of mono-and polycyclic systems as discussed by the authors, which offer high functional group tolerance and mild reaction conditions combined with high levels of regio- and stereochemistry.
References
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Journal ArticleDOI
Inside−outside stereoisomerism. II: Synthesis of the carbocyclic ring system of the ingenane diterpenes via the intramolecular dioxolenone photocycloaddition
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Stereospecific synthesis of the C30-C43 segment of palytoxin by macrocyclically controlled remote asymmetric induction
W. Clark Still,Igor Galynker +1 more
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A route for the construction of the taxane BC substructure
Journal ArticleDOI
Stereochemical control of transannular radical cyclizations. A new approach to the synthesis of linearly fused cyclopentanoids
Jeffrey D. Winkler,V. Sridar +1 more
TL;DR: Construction d'un cyclopenta [a] pentalene carboxylate-3 d'ethyle precurseur de la corioline as discussed by the authors, a cyclopentina is constructed by the construction of cyclopenia.
Journal ArticleDOI
Conformational analysis—CVI: On the 1,5-cyclooctadiene ring
Norman L. Allinger,J.T. Sprague +1 more
TL;DR: In this paper, the relative stabilities of the various conformations and the energy surfaces which interconnect them found from the calculations are used to interpret the available experimental data, and are attributed largely to the difference in torsional barriers of a saturated carbon bond when attached to a double bond, as opposed to being attached to an aromatic ring.
Related Papers (5)
Formation of a trans-bicyclo[3.3.0]Octane by tandem anionic cyclization: evidence for the highly stereoselective irreversible nature of 5-hexen-1-yllithium cyclizations
Interconversion of bicyclooctadienes and cyclooctatrienes formed by intramolecular photocycloaddition of phenyl ketones containing remote double bonds
Peter J. Wagner,Keepyung Nahm +1 more