Emerging potential mechanisms and predispositions to the neurological manifestations of COVID-19.
TLDR
In this paper, a review of the evolving molecular, cellular and systemic mechanisms of NeuroCOVID-19 is presented, which have been classified as the acute and long-term neurological effects of COVID, with particular emphasis on cerebrovascular, demyelinating and encephalitic presentations.About:
This article is published in Journal of the Neurological Sciences.The article was published on 2021-09-15 and is currently open access. It has received 13 citations till now.read more
Citations
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Long COVID and neuropsychiatric manifestations (Review)
Vasiliki Efstathiou,Maria-Ioanna Stefanou,Marina Demetriou,Nikolaos Siafakas,Michael Makris,Georgios Tsivgoulis,Vassilis Zoumpourlis,Stylianos Kympouropoulos,James T. Tsoporis,Demetrios A. Spandidos,Nikolaos Smyrnis,Emmanouil Rizos +11 more
TL;DR: Interdisciplinary cooperation for the early identification of patients who are at a high risk of persistent neuropsychiatric presentations, beyond COVID-19 recovery, is crucial to ensure that appropriate integrated physical and mental health support is provided, with the aim of mitigating the risks of long-term disability at a societal and individual level.
Journal ArticleDOI
Long COVID and the cardiovascular system—elucidating causes and cellular mechanisms in order to develop targeted diagnostic and therapeutic strategies: a joint Scientific Statement of the ESC Working Groups on Cellular Biology of the Heart and Myocardial and Pericardial Diseases
Mariann Gyöngyösi,Pilar Alcaide,Folkert W. Asselbergs,Bianca J. J. M. Brundel,Giovanni G. Camici,Paula A. da Costa Martins,Péter Ferdinandy,Marianna Fontana,Henrique Girão,Massimiliano Gnecchi,Can Gollmann-Tepeköylü,Petra Kleinbongard,Thomas Krieg,Rosalinda Madonna,M. Paillard,Antonis Pantazis,R. Perrino,Maurizio Pesce,Gabriele G. Schiattarella,Joost P.G. Sluijter,Sabine Steffens,Carsten Tschöpe,Sophie Van Linthout,Sean M. Davidson +23 more
TL;DR: In this article , the authors aim to provide insight into the possible causes and therapeutic options available for the cardiovascular manifestations of long COVID, including chronic fatigue, chest pain, ECG abnormalities, postural orthostatic tachycardia, or newly developed supraventricular or ventricular arrhythmias.
Posted ContentDOI
Profiling post-COVID syndrome across different variants of SARS-CoV-2
L. Canas,Emanuela Molteni,Juan Deng,C. Sudre,Benjamin J. Murray,Eric Kerfoot,Michela Antonelli,Lu Chen,Khaled Rjoob,Joan Capdevila Pujol,Luigi Polidori,Anna May,Marc F. Osterdahl,Ronan Whiston,Nathan J. Cheetham,Victoria L. Bowyer,Tim D. Spector,Alida Hammers,E. Loverne Duncan,Sebastien Ourselin,C. Steves,Marc Modat +21 more
TL;DR: It is evident that post-COVID syndrome presents with heterogeneous profiles, which need characterisation to enable personalised care among the most affected survivors, and how they relate to different viral variants and vaccination status is described.
Journal ArticleDOI
“Long COVID” results after hospitalization for SARS-CoV-2 infection
Marta Rigoni,Emanuele Torri,Giandomenico Nollo,Livia Delle Donne,Sebastiano Rizzardo,Lorenza Lenzi,Andrea Falzone,S Cozzio +7 more
TL;DR: In this article , the authors performed a prospective cohort study on consecutively hospitalized SARS-CoV-2 patients (March-May 2020) for evaluating COVID-19 outcomes at 6 and 12 months.
Journal ArticleDOI
“Long COVID” results after hospitalization for SARS-CoV-2 infection
Marta Rigoni,Emanuele Torri,Giandomenico Nollo,Livia Delle Donne,Sebastiano Rizzardo,Lorenza Lenzi,Andrea Falzone,S Cozzio +7 more
TL;DR: In this article , the authors performed a prospective cohort study on consecutively hospitalized SARS-CoV-2 patients (March-May 2020) for evaluating COVID-19 outcomes at 6 and 12 months.
References
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SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor
Markus Hoffmann,Hannah Kleine-Weber,Simon Schroeder,Nadine Krüger,Tanja Herrler,Sandra Erichsen,Tobias S. Schiergens,Georg Herrler,Nai Huei Wu,Andreas Nitsche,Marcel A. Müller,Christian Drosten,Christian Drosten,Stefan Pöhlmann +13 more
TL;DR: It is demonstrated that SARS-CoV-2 uses the SARS -CoV receptor ACE2 for entry and the serine protease TMPRSS2 for S protein priming, and it is shown that the sera from convalescent SARS patients cross-neutralized Sars-2-S-driven entry.
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Neurologic Manifestations of Hospitalized Patients With Coronavirus Disease 2019 in Wuhan, China.
Ling Mao,Huijuan Jin,Mengdie Wang,Yu Hu,Shengcai Chen,Quan-Wei He,Jiang Chang,Candong Hong,Yifan Zhou,David Z. Wang,Xiaoping Miao,Yanan Li,Bo Hu +12 more
TL;DR: During the epidemic period of COVID-19, clinicians should suspect severe acute respiratory syndrome coronavirus 2 infection as a differential diagnosis to avoid delayed diagnosis or misdiagnosis and lose the chance to treat and prevent further transmission.
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Endothelial cell infection and endotheliitis in COVID-19.
Zsuzsanna Varga,Andreas J. Flammer,Peter Steiger,Martina Haberecker,Rea Andermatt,Annelies S. Zinkernagel,Mandeep R. Mehra,Reto A. Schuepbach,Frank Ruschitzka,Holger Moch +9 more
TL;DR: The vascular endothelium is an active paracrine, endocrine, and Endothelial cell infection and endotheliitis in COVID-19 and recruitment of immune cells can result in widespread endothelial dysfunction associated with apoptosis.
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Dexamethasone in Hospitalized Patients with Covid-19
Peter Horby,Wei Shen Lim,Jonathan Emberson,M Mafham,Jennifer L Bell,Louise Linsell,Natalie Staplin,Christopher E. Brightling,Andrew Ustianowski,E Elmahi,B Prudon,Christopher A Green,Timothy Felton,David Chadwick,K Rege,C Fegan,Lucy C Chappell,Saul N. Faust,Thomas Jaki,Katie Jeffery,Alan A Montgomery,Kathryn M Rowan,Edmund Juszczak,J K Baillie,Richard Haynes,Martin J Landray +25 more
TL;DR: In patients hospitalized with Covid-19, the use of dexamethasone resulted in lower 28-day mortality among those who were receiving either invasive mechanical ventilation or oxygen alone at randomization but not among those receiving no respiratory support.
Journal ArticleDOI
Persistent Symptoms in Patients After Acute COVID-19.
TL;DR: This case series describes COVID-19 symptoms persisting a mean of 60 days after onset among Italian patients previously discharged from CO VID-19 hospitalization.
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