Journal ArticleDOI
Encecalol angelate, an unstable chromene from Ageratum conyzoides L.: Total synthesis and investigation of its antiprotozoal activity
Dipak Harel,Sami A. Khalid,Marcel Kaiser,Marcel Kaiser,Reto Brun,Reto Brun,Bernhard Wünsch,Thomas J. Schmidt +7 more
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TLDR
Encecalol angelate, however, is most likely not responsible for the high antitrypanosomal activity of the freshly prepared dichloromethane extract of A. conyzoides, and the synthetic approach applied here for the first time provides access to the related bioactive chromenes encecalin andEncecalol with improved yields compared with reported methods.About:
This article is published in Journal of Ethnopharmacology.The article was published on 2011-09-01. It has received 34 citations till now. The article focuses on the topics: Ageratum conyzoides & Antiprotozoal.read more
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The Potential of Secondary Metabolites from Plants as Drugs or Leads Against Protozoan Neglected Diseases – Part I
Thomas J. Schmidt,Sami A. Khalid,Alvaro J. Romanha,T. Ma. Alves,Maique W. Biavatti,Reto Brun,FB Da Costa,S. L. De Castro,Vitor F. Ferreira,M. V. G. de Lacerda,João Henrique G. Lago,Leonor L. Leon,Norberto Peporine Lopes,R. C. das Neves Amorim,Michael Niehues,Ifedayo Victor Ogungbe,Adrian Martin Pohlit,Marcus Tullius Scotti,William N. Setzer,M. de N. C. Soeiro,M. Steindel,Andre G. Tempone +21 more
TL;DR: The current review attempts to give an overview on the potential of such plant-derived natural products as antiprotozoal leads and/or drugs in the fight against NTDs.
Journal ArticleDOI
Ethnopharmacological survey of native remedies commonly used against infectious diseases in the tropical island of Mauritius
TL;DR: It is obvious that the indigenous population of Mauritius still relies to a great extent on NRs which need to be preserved and used sustainably, and further research is needed to probe the possible active constituents that could be the basis of an evidence based investigation to discover new drugs.
Journal ArticleDOI
Antioxidant capacity and phenolic content of commonly used anti-inflammatory medicinal plants in Colombia
Nora Jiménez,Luis Carrillo-Hormaza,Andrea Pujol,Fernando Alzate,Edison Osorio,Oscar J. Lara-Guzmán +5 more
TL;DR: In this article, the antioxidant capacity profile of 11 species used in traditional medicine as anti-inflammatories were determined by using different methodologies that consider electron transfer mechanisms, such as stabilization of the DPPH radical, ferric reducing antioxidant power (FRAP), Trolox equivalent antioxidant capacity (TEAC), and hydrogen atom transfer mechanisms (HAT) such as oxygen radical absorption capacity (ORAC) and the inhibition of lipid peroxidation of lipoproteins.
Journal ArticleDOI
Natural product derived antiprotozoal agents: synthesis, biological evaluation, and structure-activity relationships of novel chromene and chromane derivatives.
TL;DR: The chromene and chromane derived amines 12, 14, and 15 revealed promising antiprotozoal activity and represent novel lead compounds and were unexpectedly 10- to 25-fold more potent than chloroquine with selectivity indexes of 6760 and 1818, respectively.
Journal ArticleDOI
Antiprotozoal activity of Achillea ptarmica (Asteraceae) and its main alkamide constituents.
TL;DR: In the course of the ongoing screening of plants of the family Asteraceae for antiprotozoal activity, a CH2Cl2-extract from the flowering aerial parts of Achillea ptarmica L. b.
References
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Journal ArticleDOI
Synergy and other interactions in phytomedicines.
TL;DR: Positive and negative aspects of interactions are discussed together with the methods used to identify and measure synergy, and the evidence is divided into experimental, in vitro instances, as well as clinical examples where available.
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Ethnopharmacology and systems biology: a perfect holistic match.
TL;DR: Metabolomics will be a major tool in recognizing compounds connected with activity in the traditional medicines, and will also be very useful in recognizing the effect on the test organism, which can be the patient in case of clinical trials with well established traditional medicines.
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Ageratum conyzoides L.: A review on its phytochemical and pharmacological profile
Anjoo Kamboj,Ajay Kumar Saluja +1 more
TL;DR: Particular attention has been given to analgesic and anti-infl ammatory, antibacterial and wound healing properties, radioprotective, antifungal, anthelmintic and nematicidal, insecticidal activities of Ageratum conyzoides presented in this review such that the potential use of this plant either in pharmaceutics or as an agricultural resource can be evaluated.
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Antiprotozoal and cytotoxic naphthalene derivatives from Diospyros assimilis
TL;DR: The naphthalene derivatives 1-5 were evaluated for their in vitro antiprotozoal activity against protozoan parasites belonging to the genera Trypanosoma, Leishmania and Plasmodium and showed moderate inhibition of the growth of the parasites, T. brucei, L. donovani and L. cruzi.