Endocrine and metabolic aspects of the COVID-19 pandemic.
TLDR
Endocrine treatment modifications as a consequence of COVID-19 infection are required in a proactive manner, in order to avoid decompensation and eventual hospital admission in patients with diabetes and adrenal insufficiency.Abstract:
COVID-19 infection has tremendously impacted our daily clinical practice as well as our social living organization. Virtually all organs and biological systems suffer from this new coronavirus infection, either because the virus targets directly specific tissues or because of indirect effects. Endocrine diseases are not an exception and some of endocrine organs are at risk of direct or indirect lesion by COVID-19. Although there is still no evidence of higher predisposition to contract the infection in patients with diabetes and/or obesity, the coexistence of these conditions contributes to a worse prognosis because both conditions confer an impaired immunologic system. Cytokines storm can be amplified by these two latter conditions thereby leading to multisystemic failure and death. Glycaemic control has been demonstrated to be crucial to avoiding long hospital stays, ICU requirement and also prevention of excessive mortality. Endocrine treatment modifications as a consequence of COVID-19 infection are required in a proactive manner, in order to avoid decompensation and eventual hospital admission. This is the case of diabetes and adrenal insufficiency in which prompt increase of insulin dosage and substitutive adrenal steroids through adoption of the sick day's rules should be warranted, as well as easy contact with the health care provider through telematic different modalities. New possible endocrinological targets of COVID-19 have been recently described and warrant a full study in the next future.read more
Citations
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Vitamin D deficiency aggravates COVID-19: systematic review and meta-analysis.
Marcos Emanoel Pereira,Alialdo Dantas Damascena,Laylla Mirella Galvão Azevedo,Tarcio de Almeida Oliveira,Jerusa da Mota Santana +4 more
TL;DR: A positive association between vitamin D deficiency and the severity of the disease was observed and was identified that severe cases of COVID-19 present 64% (or 1.64; 95% CI = 1.30–2.09) moreitamin D deficiency compared with mild cases.
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Impact of COVID-19 on the thyroid gland: an update.
TL;DR: The literature search provided greater evidence that the thyroid gland and the entire hypothalamic–pituitary–thyroid (HPT) axis could be relevant targets of damage by SARS-CoV-2.
Journal ArticleDOI
COVID-19 and endocrine and metabolic diseases. An updated statement from the European Society of Endocrinology.
TL;DR: In this article, the authors have been appointed by the European Society of Endocrinology (ESE) to update with the current statement ESE members and the whole endocrine community on the emerging endocrine phenotype of COVID-19 and its implication for the prevention and management of the disease.
Journal ArticleDOI
Radiological Thoracic Vertebral Fractures are Highly Prevalent in COVID-19 and Predict Disease Outcomes
Luigi di Filippo,Anna Maria Formenti,Mauro Doga,Erika Pedone,Patrizia Rovere-Querini,Andrea Giustina +5 more
TL;DR: VFs may integrate the cardiorespiratory risk of COVID-19 patients, being a useful and easy to measure clinical marker of fragility and poor prognosis, and it is suggested that morphometric thoracic vertebral evaluation should be performed in all suspected COVID -19 patients undergoing chest x-rays.
Journal ArticleDOI
COVID-19 and the pituitary.
TL;DR: In this article, the authors reviewed the main endocrine manifestations of COVID-19 with their possible implications for pituitary diseases, the possible direct and indirect involvement of the pituitar gland in COVID, and the impact of the severe respiratory virus infection on the management of established Pituitary disease which can be already at increased risk for worse outcomes.
References
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