Journal ArticleDOI
Enhancement of natural and antibody-dependent lymphocyte cytotoxicity by drugs which inhibit prostaglandin production by tumor target cells☆
Michael J. Droller,Michael J. Droller,Peter Perlmann,Peter Perlmann,Michael Schneider,Michael Schneider +5 more
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TLDR
Evidence supports the suggestion of a mechanism in which tumor cells may prevent the effect of a cellular immune response by producing inhibitory levels of prostaglandins and suggests that manipulation of this mechanism can enhance the effectiveness of the lymphocyte response.About:
This article is published in Cellular Immunology.The article was published on 1978-08-01. It has received 100 citations till now. The article focuses on the topics: Lymphocyte & Prostaglandin.read more
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Exercise and the Immune System: Regulation, Integration, and Adaptation
TL;DR: Con considerations of the clinical ramifications of exercise in the prevention of diseases for which the immune system has a role is of importance, and the interactions between exercise and infectious diseases as well as exercise and neoplasia within the context of both aging and nutrition are addressed.
Journal ArticleDOI
Regulation of the immune response by prostaglandins.
TL;DR: A substantial body of evidence implicates prostaglandins E1 and E2 as local feedback inhibitors of T-cell activation in vitro and in vivo and results in an enhanced cellular immune response in a number of different experimental systems.
Journal ArticleDOI
Aspirin use, cancer, and polyps of the large bowel
TL;DR: The effect of aspirin use on 490 patients with cancer of the colon, 340 withcancer of the rectum as the first primary site, and 212 patients with polyps having no coexisting malignancies was compared with that of two groups of control subjects that consisted of 524 hospital patients having no cancers and no diseases of the digestive organs.
Journal ArticleDOI
Do natural killer cells engage in regulated reactions against self to ensure homeostasis
TL;DR: It is proposed that the suppression of NK cytolysis demonstrated in vitro was a manifestation of regulatory mechanisms modulating the level of NK activity in vivo.
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Inhibition of development of methylnitrosourea-induced rat colon tumors by indomethacin treatment.
TL;DR: It is postulated that indomethacin treatment may effectively prevent the development of colonic cancer in patients at high risk of Colonic adenomatosis and carcinomatsosis.
References
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Journal ArticleDOI
Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs
TL;DR: Experiments with guinea-pig lung suggest that some of the therapeutic effects of sodium salicylate and aspirin-like drugs are due to inhibition of the synthesis of prostaglandins.
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Established cell line of urinary bladder carcinoma (T24) containing tumour-specific antigen.
TL;DR: The permanent presence of tumour‐specific antigen (TSA) in this carcinoma cell line suggests that the TSA is a genetically determined characteristic of T24 cells.
Journal ArticleDOI
A possible role of prostaglandins in the inhibition of natural and antibody-dependent cell-mediated cytotoxicity against tumor cells.
Michael J. Droller,Michael J. Droller,Michael Schneider,Michael Schneider,Peter Perlmann,Peter Perlmann +5 more
TL;DR: It appears that the production of prostaglandins by tumor cells may constitute a means by which the tumor cells subvert the effect of a cellular immune response that is directed against them.
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Inhibition of tumour growth in vivo and in vitro by prostaglandin E
TL;DR: It is shown that subcutaneous administration of 16,16-dimethyl-PGE2-methyl ester significantly inhibits tumour growth in vivo, and the observations on the effects of exogenous PGE1 are extended.
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Stimulation and desensitization of macrophage adenylate cyclase by prostaglandins and catecholamines.
TL;DR: It was concluded that these two classes of hormones interact with separate receptor sites, but it is still unclear whether they affect the same or different catalytic sites.