Enteropathogen detection in children with diarrhoea, or vomiting, or both, comparing rectal flocked swabs with stool specimens: an outpatient cohort study
Stephen B. Freedman,Jianling Xie,Alberto Nettel-Aguirre,Bonita E. Lee,Linda Chui,Xiao-Li Pang,Ran Zhuo,Brendon Parsons,James A. Dickinson,Otto G. Vanderkooi,Samina Ali,Lara Osterreicher,Karen Lowerison,Phillip I. Tarr,Anderson Chuck,Gillian Currie,Mohamed Eltorki,Timothy A.D. Graham,Jason Jiang,David W. Johnson,James D. Kellner,Martin Lavoie,Marie Louie,Judy MacDonald,Shannon E. MacDonald,Kimberley Simmonds,Lawrence W. Svenson,Raymond Tellier,Steven J. Drews,James Talbot +29 more
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TLDR
Rectal swabs should be done when enteropathogen identification and rapid detection are needed, appropriate molecular diagnostic technology is available, and a stool specimen is not immediately available, in view of their high yield.About:
This article is published in The Lancet Gastroenterology & Hepatology.The article was published on 2017-09-01 and is currently open access. It has received 33 citations till now.read more
Citations
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Lactobacillus rhamnosus GG versus placebo for acute gastroenteritis in children.
David Schnadower,Phillip I. Tarr,T. Charles Casper,Marc H. Gorelick,J. Michael Dean,Karen J. O'Connell,Prashant Mahajan,Adam C. Levine,Seema Bhatt,Cindy G. Roskind,Elizabeth C. Powell,Alexander J. Rogers,Cheryl Vance,Robert E Sapien,Cody S. Olsen,Melissa Metheney,Viani P Dickey,Carla Hall-Moore,Stephen B. Freedman +18 more
TL;DR: Among preschool children with acute gastroenteritis, those who receive a 5‐day course of L. rhamnosus GG did not have better outcomes than those who received placebo, and the rate of household transmission was unchanged.
Journal ArticleDOI
Multicenter Trial of a Combination Probiotic for Children with Gastroenteritis.
Stephen B. Freedman,Sarah Williamson-Urquhart,Ken J. Farion,Serge Gouin,Andrew R. Willan,Naveen Poonai,Katrina F. Hurley,Philip M. Sherman,Yaron Finkelstein,Bonita E. Lee,Xiao-Li Pang,Linda Chui,David Schnadower,Jianling Xie,Marc H. Gorelick,Suzanne Schuh +15 more
TL;DR: In children who presented to the emergency department with gastroenteritis, twice‐daily administration of a combined L. rhamnosus–L.
Journal ArticleDOI
Comparative Evaluation of Enteric Bacterial Culture and a Molecular Multiplex Syndromic Panel in Children with Acute Gastroenteritis.
Thomas Kellner,Brendon Parsons,Linda Chui,Byron M. Berenger,Jianling Xie,Carey-Ann D. Burnham,Phillip I. Tarr,Bonita E. Lee,Alberto Nettel-Aguirre,Alberto Nettel-Aguirre,Jonas Szelewicki,Otto G. Vanderkooi,Xiao-Li Pang,Nathan Zelyas,Stephen B. Freedman +14 more
TL;DR: GPP and culture have excellent overall agreement; however, for specific pathogens, GPP is less sensitive than culture and, notably, identifies samples false positive for Salmonella spp.
Journal ArticleDOI
A randomized trial evaluating virus-specific effects of a combination probiotic in children with acute gastroenteritis
Stephen B. Freedman,Jianling Xie,Alberto Nettel-Aguirre,Xiao-Li Pang,Linda Chui,Sarah Williamson-Urquhart,David Schnadower,Suzanne Schuh,Philip M. Sherman,Bonita E. Lee,Serge Gouin,Ken J. Farion,Naveen Poonai,Katrina F. Hurley,Yuanyuan Qiu,Binal Ghandi,Colin Lloyd,Yaron Finkelstein +17 more
TL;DR: The data do not support routine probiotic administration to children with acute gastroenteritis, regardless of the infecting virus, and no virus-specific beneficial effects attributable to the probiotic are reported, either in reducing clinical symptoms or clearance of viral nucleic acid from stool specimens.
Journal ArticleDOI
Relationship between enteric pathogens and acute gastroenteritis disease severity: a prospective cohort study.
Jianling Xie,Alberto Nettel-Aguirre,Bonita E. Lee,Linda Chui,Linda Chui,Xiao-Li Pang,Xiao-Li Pang,Ran Zhuo,Brendon Parsons,Otto G. Vanderkooi,Phillip I. Tarr,Samina Ali,James A. Dickinson,E. Hagen,Lawrence W. Svenson,Shannon E. MacDonald,Shannon E. MacDonald,Steven J. Drews,Steven J. Drews,Raymond Tellier,Raymond Tellier,Timothy A.D. Graham,Timothy A.D. Graham,Marc C. Lavoie,Judy MacDonald,Stephen B. Freedman +25 more
TL;DR: In children presenting for emergency department care with acute gastroenteritis, pathogens identified were predominantly viruses, and several of which were associated with severe disease.
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Alfredo Guarino,Shai Ashkenazi,Dominique Gendrel,Andrea Lo Vecchio,Raanan Shamir,Hania Szajewska +5 more
TL;DR: In this paper, the authors present evidence-based indications for the management of children with acute gastroenteritis in Europe, including oral rehydration with hypoosmolar solution is the major treatment and should start as soon as possible.
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Better tests, better care: improved diagnostics for infectious diseases.
Angela M. Caliendo,David N. Gilbert,David N. Gilbert,Christine C. Ginocchio,Kimberly E. Hanson,Larissa S May,Thomas C. Quinn,Thomas C. Quinn,Fred C. Tenover,David Alland,Anne J. Blaschke,Robert A. Bonomo,Karen C. Carroll,Mary Jane Ferraro,Lisa R. Hirschhorn,W. Patrick Joseph,Tobi Karchmer,Ann T MacIntyre,L. Barth Reller,Audrey F. Jackson +19 more
TL;DR: The current diagnostic landscape, including unmet needs and emerging technologies, and the challenges to the development and clinical integration of improved tests are reviewed, and recommendations that address a host of identified barriers are presented.