Establishment of a neonatal rhesus macaque model to study Mycobacterium tuberculosis infection.
Magdalena Cepeda,Mary Salas,Jessica Folwarczny,Ana Cristina C. S. Leandro,Vida L. Hodara,Melissa De La Garza,Edward J. Dick,Michael A. Owston,Lisa Y. Armitige,Marie Claire Gauduin +9 more
Reads0
Chats0
TLDR
An aerosol newborn/infant model in neonatal nonhuman primates (NHPs) is established that mimics clinical and bacteriological characteristics of Mtb infection as seen in human newborns/infants and allows the establishment of a TB coinfection model of pediatric AIDS.About:
This article is published in Tuberculosis.The article was published on 2013-12-01 and is currently open access. It has received 14 citations till now. The article focuses on the topics: Tuberculosis & Pediatric AIDS.read more
Citations
More filters
Journal ArticleDOI
Monkey Models of Tuberculosis: Lessons Learned
TL;DR: This review focuses on published major studies which illustrate how the rhesus and cynomolgus macaques have enriched and may continue to advance the field of global tuberculosis research.
Journal ArticleDOI
Non-Human Primate Models of Tuberculosis
Juliet C. Peña,Wen-Zhe Ho +1 more
TL;DR: This review focuses on published major studies that exemplify how the rhesus and cynomolgus macaques have enhanced and may continue to advance global efforts in TB research.
Journal ArticleDOI
TNF-α blockade impairs in vitro tuberculous granuloma formation and down modulate Th1, Th17 and Treg cytokines.
Djalma Alexandre Alves da Silva,Marcos Vinicius da Silva,Cleyson C Oliveira Barros,Patricia B. D. Alexandre,Rodolfo Pessato Timóteo,Jonatas da Silva Catarino,Helioswilton Sales-Campos,Juliana Reis Machado,Denise Bertulucci Rocha Rodrigues,Carlo José Freire Oliveira,Virmondes Rodrigues +10 more
TL;DR: It is demonstrated that TNF-α blockade by Infliximab directly influenced the structure of granuloma only in the treated TB group, but negatively modulated the production of Th1, Th17 and regulatory T cytokines in the three groups analyzed.
Journal ArticleDOI
One Size Fits All? Not in In Vivo Modeling of Tuberculosis Chemotherapeutics.
TL;DR: A review of vertebrate animal models used in evaluating compound activity against Mycobacterium tuberculosis (Mtb) and the disease presentation that develops is presented in this article.
Journal ArticleDOI
Neonatal and infant immunity for tuberculosis vaccine development: importance of age-matched animal models.
TL;DR: The animal models of neonatal and infant immunity are compared and the potential of piglets as important models for vaccine development is highlighted, to encourage the development of Neonatal animal models for TB, especially the use of pigs.
References
More filters
Journal ArticleDOI
WHO guidelines for the programmatic management of drug-resistant tuberculosis: 2011 update
Dennis Falzon,Ernesto Jaramillo,Holger J. Schünemann,Matthew Arentz,Melissa Bauer,Jaime Bayona,Léopold Blanc,Jose A. Caminero,Charles L. Daley,Chris Duncombe,Christopher Fitzpatrick,Agnes Gebhard,Haileyesus Getahun,Myriam Henkens,Timothy H. Holtz,J. Keravec,S. Keshavjee,Aamir J. Khan,R. Kulier,Vaira Leimane,Christian Lienhardt,Chunling Lu,Mar'iandyshev Ao,Giovanni Battista Migliori,Fuad Mirzayev,Carole D. Mitnick,Paul Nunn,G. Nwagboniwe,Olivia Oxlade,Domingo Palmero,Patricia B Pavlinac,M. I. D. Quelapio,Mario C. Raviglione,Michael Rich,S. Royce,Sabine Rüsch-Gerdes,A. Salakaia,R. Sarin,Delphine Sculier,Francis Varaine,Marco Vitoria,Judd L. Walson,Fraser Wares,Karin Weyer,Richard A. White,Matteo Zignol +45 more
TL;DR: The guidelines promote the early use of antiretroviral agents for TB patients with HIV on second-line drug regimens and systems that primarily employ ambulatory models of care are recommended over others based mainly on hospitalisation.
Journal ArticleDOI
Experimental Mycobacterium tuberculosis infection of cynomolgus macaques closely resembles the various manifestations of human M. tuberculosis infection.
Saverio Capuano,Denise A. Croix,Santosh Pawar,Angelica Zinovik,Amy J. Myers,Philana Ling Lin,Stephanie J. Bissel,Carl R. Fuhrman,Edwin Klein,JoAnne L. Flynn +9 more
TL;DR: Low-dose infection of cynomolgus macaques appears to represent the full spectrum of human M. tuberculosis infection and will be an excellent model for the study of pathogenesis and immunology of this infection.
Journal ArticleDOI
Detection and Molecular Characterization of 9000-Year-Old Mycobacterium tuberculosis from a Neolithic Settlement in the Eastern Mediterranean
Israel Hershkovitz,Helen D. Donoghue,David E. Minnikin,Gurdyal S. Besra,Oona Y.-C. Lee,Angela M. Gernaey,Ehud Galili,Vered Eshed,Charles L. Greenblatt,Eshetu Lemma,Gila Kahila Bar-Gal,Mark Spigelman,Mark Spigelman +12 more
TL;DR: Human tuberculosis was confirmed by morphological and molecular methods in a population living in one of the first villages with evidence of agriculture and animal domestication and gave support to the theory of a long-term co-existence of host and pathogen.
Journal ArticleDOI
Tuberculosis in children.
TL;DR: The result is a readable book, well illustrated and simple but comprehensive and authorita tive, the weakest part is that on cardiac surgery, but this is understandable, since rapid developments had out distanced the written account by the time the book had been printed and published.
Journal ArticleDOI
Dissemination of Mycobacterium tuberculosis is influenced by host factors and precedes the initiation of T-cell immunity.
TL;DR: It is reported that dissemination of Mycobacterium tuberculosis in the mouse is under host control and precedes the initiation of T-cell immunity, and it is hypothesize that this early initiation of immunity following inoculation with M. tuberculosis may contribute to the superior resistance of C57BL/6 mice.
Related Papers (5)
Differential virulence and disease progression following Mycobacterium tuberculosis complex infection of the common marmoset (Callithrix jacchus).
Laura E. Via,Danielle M. Weiner,Daniel Schimel,Philana Ling Lin,Emmanuel Dayao,Sarah L. Tankersley,Ying Cai,M. Teresa Coleman,Jaime Tomko,Praveen Paripati,Marlene Orandle,Robin J. Kastenmayer,Michael Tartakovsky,Alex Rosenthal,Damien Portevin,Seok Yong Eum,Saher Lahouar,Sebastien Gagneux,Douglas B. Young,JoAnne L. Flynn,Clifton E. Barry +20 more