Estrogen Receptor Beta 1: A Potential Therapeutic Target for Female Triple Negative Breast Cancer.
Parama Dey,Alexander Wang,Yvonne S. Ziegler,Sandeep Kumar,Shunchao Yan,Sung H. Kim,John A. Katzenellenbogen,Benita S. Katzenellenbogen +7 more
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TLDR
Gene expression analysis revealed that treatment with CLI, an ERβ selective agonist ligand often enhanced the suppressive activity of ERβ1 in T NBCs in vivo or in TNBC cells in culture, suggesting the potential utility of ER β1 and ERβ ligand in improving TNBC treatment.Abstract:
Triple Negative Breast Cancer (TNBC) is an aggressive subtype of breast cancer characterized by the absence of estrogen receptor alpha, progesterone receptor, and HER2. These receptors often serve as targets in breast cancer treatment. As a result, TNBCs are difficult to treat and have a high propensity to metastasize to distant organs. For these reasons, TNBCs are responsible for over 50% of all breast cancer mortalities while only accounting for 15% - 20% of breast cancer cases. However, estrogen receptor beta 1 (ERβ1), an isoform of the ESR2 gene, has emerged as a potential therapeutic target in the treatment of TNBCs. Using an in vivo xenograft preclinical mouse model with human TNBC, we found that expression of ERβ1 significantly reduced both primary tumor growth and metastasis. Moreover, TNBCs with elevated levels of ERβ1 showed reduction in epithelial-to-mesenchymal transition (EMT) markers and breast cancer stem cell (BCSC) markers, and increases in the expression of genes associated with inhibition of cancer cell invasiveness and metastasis, suggesting possible mechanisms underlying the antitumor activity of ERβ1. Gene expression analysis by qPCR and RNA-seq revealed that treatment with CLI, an ERβ selective agonist ligand often enhanced the suppressive activity of ERβ1 in TNBCs in vivo or in TNBC cells in culture, suggesting the potential utility of ERβ1 and ERβ ligand in improving TNBC treatment. The findings enable understanding of the mechanisms by which ERβ1 impedes TNBC growth, invasiveness and metastasis and consideration of ways by which treatments involving ERβ might improve TNBC patient outcome.read more
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Estrogen Receptor Beta 1: A Potential Therapeutic Target for Female Triple Negative Breast Cancer.
Parama Dey,Alexander Wang,Yvonne S. Ziegler,Sandeep Kumar,Shunchao Yan,Sung H. Kim,John A. Katzenellenbogen,Benita S. Katzenellenbogen +7 more
TL;DR: Gene expression analysis revealed that treatment with CLI, an ERβ selective agonist ligand often enhanced the suppressive activity of ERβ1 in T NBCs in vivo or in TNBC cells in culture, suggesting the potential utility of ER β1 and ERβ ligand in improving TNBC treatment.
Journal ArticleDOI
Anticancer or carcinogenic? The role of estrogen receptor β in breast cancer progression.
TL;DR: Wang et al. as discussed by the authors reviewed the anticancer and oncogenic effects of ERβ on breast cancer progression in the past ten years, discuss the mechanism respectively, analyze the main reasons for the inconsistency and update ERβ selective ligand library.
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Updates on Triple-Negative Breast Cancer in Type 2 Diabetes Mellitus Patients: From Risk Factors to Diagnosis, Biomarkers and Therapy
TL;DR: In this article , the authors provide up-to-date information related to epidemiology and clinicopathological features, risk factors, diagnosis, biomarkers, and current therapy/clinical trials for triple negative breast cancer patients with Type 2 diabetes mellitus compared to non-diabetic counterparts.
Journal ArticleDOI
Potential Therapeutic Targets for Luminal Androgen Receptor Breast Cancer: What We Know so Far
Stefania Stella,Federica Martorana,Michele Massimino,Silvia Rita Vitale,Livia Manzella,Paolo Vigneri +5 more
TL;DR: In this paper , the authors explored combinations of anti-androgen agents with other targeted therapies, including PI3K/mToR, HER2, BRCA1, cell cycle and immune modulation, to find new and effective therapeutic targets, eventually improving patients' outcomes.
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Estrogen Receptor β4 Regulates Chemotherapy Resistance and Induces Cancer Stem Cells in Triple Negative Breast Cancer
TL;DR: In this paper , the role of ERβ1 and ERβ4 in influencing chemotherapy sensitivity has been studied, and it was shown that the truncated ERβ 1 LBD in a variety of mutant p53 TNBC cell lines had increased resistance to Paclitaxel, whereas the ERβ 4 knockdown cell line was sensitized to Pac Litaxel.
References
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