Journal ArticleDOI
Evaluation of ethyl gallate for its antioxidant and anticancer properties against chemical-induced tongue carcinogenesis in mice.
TLDR
Acacia nilotica (L.) leaf extract and ethyl gallate (EG), a phenolic compound present in AN, shows strong hope as drugs against oral cancer progression and the involvement of apoptosis in vivo is brought out.Abstract:
Cancer arising in the oral cavity is one of the major causes of mortality worldwide and demands immediate attention. Regardless of the use of advanced treatment for oral cancer, successful treatment resulting in cancer survival is low. Currently available drugs are ineffective and are toxic. Therefore, successful treatment without toxic effects remains essential. This is quite challenging, leading to the identification of natural bioactive compounds for oral cancer treatment. Thus, a plant extract rich in phenolics is preferred for studying the cellular, biochemical and molecular changes associated with oral carcinogenesis.The present study aims to deal with the above need using Acacia nilotica (L.) leaf extract (AN) and ethyl gallate (EG), a phenolic compound present in AN against oral carcinogenesis. Extension of a tumor cell line to a mouse model was investigated with 4-nitroquinoline 1-oxide (4-NQO) as carcinogen, a surrogate for tobacco. The progression of squamous cell carcinoma (SCC) was achieved through hyperplasia and dysplasia after 4-NQO induction in Swiss albino mice. Administration of AN and EG to animals undergoing dysplasia led to the inhibition of SCC, thereby reducing the tumor burden. The antioxidant capacity of AN and EG was also brought out via biochemical analysis. Further investigation of biomarkers in tongue tissues revealed the involvement of apoptosis in vivo Moreover, no adverse or toxic effect was observed earlier in rats upon oral administration of AN and EG. Thus, AN and EG shows strong hope as drugs against oral cancer progression.read more
Citations
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Journal ArticleDOI
Inhibitory Effects of Ethyl Gallate on Streptococcus mutans Biofilm Formation by Optical Profilometry and Gene Expression Analysis.
Vika Gabe,Tomas Kacergius,Saleh Abu-Lafi,Povilas Kalesinskas,Mahmud Masalha,Mizied Falah,Mizied Falah,Basheer Abu-Farich,Andrius Melninkaitis,Mouhammad Zeidan,Anwar Rayan +10 more
TL;DR: EG has the capacity to inhibit S. mutans biofilm formation on solid surfaces (polystyrene, glass), as well as acidogenicity, and might be used as an antibiofilm and/or anticaries agent for oral formulations in order to reduce the prevalence of dental caries.
Journal ArticleDOI
LC-ESI-QTOF-MS for the Profiling of the Metabolites and in Vitro Enzymes Inhibition Activity of Bryophyllum pinnatum and Oxalis corniculata Collected from Ramechhap District of Nepal.
TL;DR: The finding suggested that these two plant species have high medicinal importance and are potential source of inhibitors for modern pharmaceuticals, nutraceuticals and cosmetics industries.
Journal ArticleDOI
The Potential of Flavonoids and Tannins from Medicinal Plants as Anticancer Agents.
TL;DR: The cytostatic/antitumor effect of the individual compounds extracted from plants and/or of the plants polyphenolic extracts are considered, in order to point out the most significant constituents or plants with anticancer potential.
Journal ArticleDOI
Ethyl gallate as a novel ERK1/2 inhibitor suppresses patient-derived esophageal tumor growth.
Feifei Liu,Xueyin Zu,Xiaomeng Xie,Kangdong Liu,H. S. Chen,Ting Wang,Fangfang Liu,Ann M. Bode,Yan Zheng,Zigang Dong,Dong Joon Kim +10 more
TL;DR: Ethyl gallate is a novel ERK1/2 inhibitor that suppresses esophageal cancer growth in vitro and in vivo and could be useful for treating esophagal cancer.
Journal ArticleDOI
Integration of medicinal plants into the traditional system of medicine for the treatment of cancer in Sokoto State, Nigeria.
Ibrahim Malami,Nasiru Muhammad Jagaba,Ibrahim Babangida Abubakar,Aliyu Muhammad,Alhassan Muhammad Alhassan,Peter Maitama Waziri,Ibrahim Zakiyya Yakubu Yahaya,Halilu E. Mshelia,Sylvester Nefy Mathias +8 more
TL;DR: The present study provides a baseline for future pharmacological investigations into the beneficial effects of such medicinal plants for the treatment of cancer and explores and record various medicinal plants integrated into the traditional system of medicine of Sokoto state.
References
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