Evidence of a causal relationship between body mass index and psoriasis: A mendelian randomization study
Ashley Budu-Aggrey,Ben Michael Brumpton,Jess Tyrrell,Jess Tyrrell,Sarah H Watkins,Ellen Heilmann Modalsli,Carlos Celis-Morales,Lyn D. Ferguson,Gunnhild Åberge Vie,Tom Palmer,Lars G. Fritsche,Mari Løset,Jonas B. Nielsen,Wei Zhou,Lam C. Tsoi,Andrew R. Wood,Samuel E. Jones,Robin N Beaumont,Marit Saunes,Pål Richard Romundstad,Stefan Siebert,Iain B. McInnes,James T. Elder,James T. Elder,George Davey Smith,Timothy M. Frayling,Bjørn Olav Åsvold,Sara J. Brown,Sara J. Brown,Naveed Sattar,Lavinia Paternoster +30 more
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TLDR
Evidence that higher BMI leads to a higher risk of psoriasis is provided, which supports the prioritization of therapies and lifestyle interventions aimed at controlling weight for the prevention or treatment of this common skin disease.Abstract:
In a mendelian randomization study, Ashley Budu-Aggrey and co-workers study the influence of body mass index on psoriasis.read more
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Obesity a Risk Factor for Severe COVID-19 Infection: Multiple Potential Mechanisms
TL;DR: It is suggested obesity or excess ectopic fat deposition may be a unifying risk factor for severe COVID-19 infection, reducing protective cardiorespiratory reserve as well as potentiating the immune dysregulation that appears to mediate the progression to critical illness and organ failure in a proportion of patients with CO VID-19.
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Obesity in COVID-19 era, implications for mechanisms, comorbidities, and prognosis: a review and meta-analysis.
Seyed Morsal Mosallami Aghili,Mahbube Ebrahimpur,Babak Arjmand,Zhaleh Shadman,Mahnaz Pejman Sani,Mostafa Qorbani,Bagher Larijani,Moloud Payab +7 more
TL;DR: In this article, the authors reviewed clinical studies to clarify the obesity relationship with COVID-19 severity, comorbidities, and discussing possible mechanisms, and found that obese patients had a longer virus shedding.
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The current landscape of psoriasis genetics in 2020.
Kotaro Ogawa,Yukinori Okada +1 more
TL;DR: The current and future landscape of psoriasis genetics is detailed and the cutting-edge use of large-scale GWAS data, especially in the Japanese population is introduced.
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Cardiometabolic comorbidities in RA and PsA: lessons learned and future directions.
TL;DR: Patients with RA have a higher risk of cardiovascular disease than individuals of the general population; however, some of this increased risk might be driven by steroid use, and weight loss might reduce disease severity and/or risk of PsA development, but future prospective studies are needed to assess the effects of lifestyle interventions and/ or pharmacologically induced weight loss.
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Immune-mediated inflammatory disease therapeutics: past, present and future.
TL;DR: McInnes and Gravallese as mentioned in this paper highlighted the remarkable progress made over the past 20 years in treating immune-mediated inflammatory diseases and highlighted key advances and lessons that drove this remarkable progress and thereafter reflect on the next steps in this ongoing journey.
References
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Genetic studies of body mass index yield new insights for obesity biology
Glgc,Icbp,Magic Investigators +2 more
TL;DR: A genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals provide strong support for a role of the central nervous system in obesity susceptibility.
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Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression
TL;DR: An adaption of Egger regression can detect some violations of the standard instrumental variable assumptions, and provide an effect estimate which is not subject to these violations, and provides a sensitivity analysis for the robustness of the findings from a Mendelian randomization investigation.
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