Journal ArticleDOI
Excitatory actions of gaba during development: the nature of the nurture.
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This work proposes that GABA becomes inhibitory by the delayed expression of a chloride exporter, leading to a negative shift in the reversal potential for choride ions, and provides a solution to the problem of how to excite developing neurons to promote growth and synapse formation.Abstract:
In the immature brain, GABA (gamma-aminobutyric acid) is excitatory, and GABA-releasing synapses are formed before glutamatergic contacts in a wide range of species and structures. GABA becomes inhibitory by the delayed expression of a chloride exporter, leading to a negative shift in the reversal potential for choride ions. I propose that this mechanism provides a solution to the problem of how to excite developing neurons to promote growth and synapse formation while avoiding the potentially toxic effects of a mismatch between GABA-mediated inhibition and glutamatergic excitation. As key elements of this cascade are activity dependent, the formation of inhibition adds an element of nurture to the construction of cortical networks.read more
Citations
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Model of autism: increased ratio of excitation/inhibition in key neural systems
TL;DR: In this paper, a model that postulates that some forms of autism are caused by an increased ratio of excitation/inhibition in sensory, mnemonic, social and emotional systems is proposed.
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Variations on an inhibitory theme : phasic and tonic activation of GABA(A) receptors
Mark Farrant,Zoltan Nusser +1 more
TL;DR: This review considers the distinct roles of synaptic and extrasynaptic GABA receptor subtypes in the control of neuronal excitability in the adult mammalian brain.
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Synaptic mechanisms of synchronized gamma oscillations in inhibitory interneuron networks
TL;DR: Experimental analysis in the hippocampus and the neocortex and computational analysis suggests that synaptic specialization turns interneuron networks into robust gamma frequency oscillators.
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Adult neurogenesis and functional plasticity in neuronal circuits
TL;DR: This work has shown that in two areas of the adult brain, new neurons are generated throughout life and form an integral part of the normal functional circuitry, revealing a plastic mechanism by which the brain's performance can be optimized for a given environment.
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Epigenetic Regulations of GABAergic Neurotransmission: Relevance for Neurological Disorders and Epigenetic Therapy
TL;DR: How various genetic and epigenetic events regulate the GABAergic genes in pre- and postnatal brain contribute to the pathogenesis of neurological disorders and can be used in the development of potential epigenetic therapy for these diseases.
References
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Journal ArticleDOI
Activity‐ and age‐dependent GABAergic synaptic plasticity in the developing rat hippocampus
TL;DR: The results show that long‐term changes in GABAergic synaptic activity can be induced during a restricted period of development by a conditioning protocol relevant to the physiological condition.
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Development of spinal motor networks in the chick embryo
Michael J. O'Donovan,Evelyne Sernagor,Gerald Sholomenko,Stephen M. Ho,Miklós Antal,Wayne Yee +5 more
TL;DR: The findings suggest that functional descending connections from the brainstem to the lumbar cord are present by E7, although activation of ascending axons or electrical synapses cannot be eliminated.
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Spontaneous activity in developing turtle retinal ganglion cells: Pharmacological studies
TL;DR: It is concluded that correlated SBA in immature turtle GCs requires both cholinergic nicotinic and glutamatergic (mainly through AMPA/kainate receptors) synaptic transmission, which modulates the intensity and the duration of the bursts.
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Pharmacological evidence for GABAergic regulation of specific behaviors in Drosophila melanogaster.
TL;DR: The existence of experimentally accessible GABA transporters in Drosophila that share conserved pharmacological properties with their mammalian counterparts has resulted in the identification of specific behaviors that are modulated by GABA.
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Temporal Patterns and Depolarizing Actions of Spontaneous GABAA Receptor Activation in Granule Cells of the Early Postnatal Dentate Gyrus
TL;DR: The results show that the spontaneous activation of GABAA receptors in immature dentate granule cells displays unique properties that are distinct from the temporal patterns and biophysical features of spontaneous GAB AA receptor activation taking place in the developing Ammon's horn and in the adult dentate gyrus.