Journal ArticleDOI
Excitatory actions of gaba during development: the nature of the nurture.
Reads0
Chats0
TLDR
This work proposes that GABA becomes inhibitory by the delayed expression of a chloride exporter, leading to a negative shift in the reversal potential for choride ions, and provides a solution to the problem of how to excite developing neurons to promote growth and synapse formation.Abstract:
In the immature brain, GABA (gamma-aminobutyric acid) is excitatory, and GABA-releasing synapses are formed before glutamatergic contacts in a wide range of species and structures. GABA becomes inhibitory by the delayed expression of a chloride exporter, leading to a negative shift in the reversal potential for choride ions. I propose that this mechanism provides a solution to the problem of how to excite developing neurons to promote growth and synapse formation while avoiding the potentially toxic effects of a mismatch between GABA-mediated inhibition and glutamatergic excitation. As key elements of this cascade are activity dependent, the formation of inhibition adds an element of nurture to the construction of cortical networks.read more
Citations
More filters
Journal ArticleDOI
Age-dependent Spontaneous Hyperexcitability and Impairment of GABAergic Function in the Hippocampus of Mice Lacking trkB
Maria A. Carmona,Esther Pozas,Albert Martínez,Juan F. Espinosa-Parrilla,Eduardo Soriano,Fernando Aguado +5 more
TL;DR: The results indicate that the lack of TrkB signaling during development impairs GABAergic neurotransmission, thereby leading to an age-dependent decrease followed by an increase in the intrinsic excitability of neuronal circuits.
Journal ArticleDOI
Neurons on the move: migration and lamination of cortical interneurons.
TL;DR: The notion of additional sources of interneuron progenitors found in human and non-human primates are discussed and the disruption of early developmental events can instigate a loss in GABAergic function are illustrated.
Journal ArticleDOI
Sex-dependent effects of nicotine on the developing brain.
TL;DR: It is shown that gonadal hormone‐mediated sexual differentiation of the brain may be an important determinant of sex differences in the effects of nicotine, and the importance of including these factors in preclinical research that models tobacco dependence is stressed.
Journal ArticleDOI
Restoring GABAergic inhibition rescues memory deficits in a Huntington’s disease mouse model
Zahra Dargaei,Jee Yoon Bang,Vivek Mahadevan,C. Sahara Khademullah,Simon Bedard,Gustavo M. Parfitt,Jun Chul Kim,Melanie A. Woodin +7 more
TL;DR: It is demonstrated that the action of the neurotransmitter GABA has switched from inhibitory to excitatory, and by treating HD mice with a clinically used diuretic (bumetanide), which restores inhibitory GABA, rescued the learning and memory deficits.
Journal ArticleDOI
Intracellular chloride ions regulate the time-course of GABA-mediated inhibitory synaptic transmission
TL;DR: The decay time course of GABAergic inhibitory synaptic currents is considerably faster when recorded with physiological internal Cl− concentrations than with symmetrical Cl− solutions, due to a direct modulation of the GABAA receptor.
References
More filters
Journal ArticleDOI
The K+/Cl- co-transporter KCC2 renders GABA hyperpolarizing during neuronal maturation.
Claudio Rivera,Juha Voipio,John A. Payne,Eva Ruusuvuori,Hannele Lahtinen,Karri Lamsa,Ulla Pirvola,Mart Saarma,Kai Kaila +8 more
TL;DR: It is shown that, in pyramidal neurons of the rat hippocampus, the ontogenetic change in GABAA-mediated responses from depolarizing to hyperpolarizing is coupled to a developmental induction of the expression of the neuronal Cl−-extruding K+/Cl − co-transporter, KCC2 (ref. 7).
Journal ArticleDOI
Gamma (40-100 Hz) oscillation in the hippocampus of the behaving rat
TL;DR: It is suggested that gamma oscillation emerges from an interaction between intrinsic oscillatory properties of interneurons and the network properties of the dentate gyrus and that Gamma oscillation in the CA3-CA1 circuitry is suppressed by either the hilar region or the entorhinal cortex.
Journal ArticleDOI
Synaptic Assembly of the Brain in the Absence of Neurotransmitter Secretion
Matthijs Verhage,Ascanio S. Maia,Jaap J. Plomp,Arjen B. Brussaard,J H Heeroma,H. Vermeer,Ruud F. Toonen,Robert E. Hammer,T K van den Berg,Markus Missler,Hans J. Geuze,Thomas C. Südhof +11 more
TL;DR: Synaptic connectivity does not depend on neurotransmitter secretion, but its maintenance does, and neurotransmitter secretion probably functions to validate already established synaptic connections.
Journal ArticleDOI
Giant synaptic potentials in immature rat CA3 hippocampal neurones.
TL;DR: In neurones in which evoked GDPs were blocked by bicuculline, a NMDA‐mediated component was revealed by increasing the strength or the frequency of stimulation, and during the second week of postnatal life, superfusion with bicuciulline induced, as in adult slices, interictal discharges.