Journal ArticleDOI
Excitatory actions of gaba during development: the nature of the nurture.
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This work proposes that GABA becomes inhibitory by the delayed expression of a chloride exporter, leading to a negative shift in the reversal potential for choride ions, and provides a solution to the problem of how to excite developing neurons to promote growth and synapse formation.Abstract:
In the immature brain, GABA (gamma-aminobutyric acid) is excitatory, and GABA-releasing synapses are formed before glutamatergic contacts in a wide range of species and structures. GABA becomes inhibitory by the delayed expression of a chloride exporter, leading to a negative shift in the reversal potential for choride ions. I propose that this mechanism provides a solution to the problem of how to excite developing neurons to promote growth and synapse formation while avoiding the potentially toxic effects of a mismatch between GABA-mediated inhibition and glutamatergic excitation. As key elements of this cascade are activity dependent, the formation of inhibition adds an element of nurture to the construction of cortical networks.read more
Citations
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The Interesting Interplay Between Interneurons and Adult Hippocampal Neurogenesis
TL;DR: This work focuses on activity- and signaling-dependent mechanisms, as well as research on human diseases that could provide better insight into how interneurons in general might add to the comprehension of the regulation and function of adult hippocampal neurogenesis.
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General Anesthetics and Neurotoxicity: How Much Do We Know?
TL;DR: An overview of anesthesia-induced developmental neurotoxicity and commentary on the effects of general anesthesia on the aging brain are provided.
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Spontaneous Network Activity and Synaptic Development
TL;DR: Common mechanisms and patterns of spontaneous activity in emerging neural networks are reviewed and recent insights into their contribution to synaptic development are discussed.
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Molecular and functional expression of cation-chloride cotransporters in dorsal root ganglion neurons during postnatal maturation
Shihong Mao,Tomas Garzon-Muvdi,Mauricio Di Fulvio,Yanfang Chen,Eric Delpire,Francisco J. Alvarez,Francisco J. Alvarez-Leefmans +6 more
TL;DR: Immunolabeling with validated antibodies revealed ubiquitous expression of NKCC1 in DRG neurons irrespective of postnatal age and phenotype, and mechanisms underlying PANs' developmental changes in Cl(-) homeostasis are discussed and compared with those of central neurons.
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Identification of neuronal network properties from the spectral analysis of calcium imaging signals in neuronal cultures.
TL;DR: In this article, the authors use spectral analysis to characterize global dynamical and structural traits of the neuronal cultures and show that the power spectrum can be used as a signature of the state of the network, for instance when inhibition is active or silent, as well as a measure of the connectivity strength.
References
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Journal ArticleDOI
The K+/Cl- co-transporter KCC2 renders GABA hyperpolarizing during neuronal maturation.
Claudio Rivera,Juha Voipio,John A. Payne,Eva Ruusuvuori,Hannele Lahtinen,Karri Lamsa,Ulla Pirvola,Mart Saarma,Kai Kaila +8 more
TL;DR: It is shown that, in pyramidal neurons of the rat hippocampus, the ontogenetic change in GABAA-mediated responses from depolarizing to hyperpolarizing is coupled to a developmental induction of the expression of the neuronal Cl−-extruding K+/Cl − co-transporter, KCC2 (ref. 7).
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Gamma (40-100 Hz) oscillation in the hippocampus of the behaving rat
TL;DR: It is suggested that gamma oscillation emerges from an interaction between intrinsic oscillatory properties of interneurons and the network properties of the dentate gyrus and that Gamma oscillation in the CA3-CA1 circuitry is suppressed by either the hilar region or the entorhinal cortex.
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Synaptic Assembly of the Brain in the Absence of Neurotransmitter Secretion
Matthijs Verhage,Ascanio S. Maia,Jaap J. Plomp,Arjen B. Brussaard,J H Heeroma,H. Vermeer,Ruud F. Toonen,Robert E. Hammer,T K van den Berg,Markus Missler,Hans J. Geuze,Thomas C. Südhof +11 more
TL;DR: Synaptic connectivity does not depend on neurotransmitter secretion, but its maintenance does, and neurotransmitter secretion probably functions to validate already established synaptic connections.
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Giant synaptic potentials in immature rat CA3 hippocampal neurones.
TL;DR: In neurones in which evoked GDPs were blocked by bicuculline, a NMDA‐mediated component was revealed by increasing the strength or the frequency of stimulation, and during the second week of postnatal life, superfusion with bicuciulline induced, as in adult slices, interictal discharges.