Journal ArticleDOI
Experimental Campylobacter jejuni Infection in Humans
Robert E. Black,Myron M. Levine,Myron M. Levine,Mary Lou Clements,Mary Lou Clements,Timothy P. Hughes,Timothy P. Hughes,Martin J. Blaser,Martin J. Blaser +8 more
TLDR
Two strains of Campylobacter jejuni ingested by 111 adult volunteers, in doses ranging from 8 x 10(2) to 2x 10(9) organisms, caused diarrheal illnesses that indicates that the pathogenesis of C.Jejuni infection includes tissue inflammation.Abstract:
Two strains of Campylobacter jejuni ingested by 111 adult volunteers, in doses ranging from 8 x 10(2) to 2 x 10(9) organisms, caused diarrheal illnesses. Rates of infection increased with dose, but development of illness did not show a clear dose relation. Resulting illnesses with strain A3249 ranged from a few loose stools to dysentery, with an average of five diarrheal stools and a volume of 509 mL. Infection with strain 81-176 was more likely to cause illness, and these illnesses were more severe, with an average of 15 stools and 1484 mL of total stool volume. All patients had fecal leukocytes. The dysenteric nature of the illness indicates that the pathogenesis of C. jejuni infection includes tissue inflammation. Ill volunteers developed a serum antibody response to the C. jejuni group antigen and were protected from subsequent illness but not infection with the same strain.read more
Citations
More filters
Book
Recent Advances in Animal Nutrition
TL;DR: In this article, the authors investigated the effect of nutrition on stress and immunity in dairy cows and discussed the potential applications of GM technology on pig performance and piglet starter feeding in a changing business environment, with special emphasis on tryptophan and valine.
Journal ArticleDOI
Campylobacter jejuni Infections: Update on Emerging Issues and Trends
TL;DR: Infection with Campylobacter jejuni is one of the most common causes of gastroenteritis worldwide; it occurs more frequently than do infections caused by Salmonella species, Shigella species, or Escherichia coli O157:H7.
Journal ArticleDOI
Fresh produce: a growing cause of outbreaks of foodborne illness in the United States, 1973 through 1997.
TL;DR: Foodborne outbreaks associated with fresh produce in the United States have increased in absolute numbers and as a proportion of all reported foodborne outbreaks, and Cyclospora and Escherichia coli O157:H7 were newly recognized as causes of foodborne illness.
Journal ArticleDOI
Global Epidemiology of Campylobacter Infection
TL;DR: Overall, campylobacteriosis is still one of the most important infectious diseases that is likely to challenge global health in the years to come.
Journal ArticleDOI
Campylobacter jejuni—An Emerging Foodborne Pathogen
TL;DR: M Mishandling of raw poultry and consumption of undercooked poultry are the major risk factors for human campylobacteriosis, and efforts to prevent human illness are needed throughout each link in the food chain.
References
More filters
Journal ArticleDOI
Campylobacter Enteritis: Clinical and Epidemiologic Features
TL;DR: Review of 35 cases of campylobacter enteritis identified a typical clinical syndrome with acute onset of diarrhea, abdominal pain, fever, and constitutional symptoms, and Epidemiologic investigation strongly suggested an external source for the infection in 22 of 35 patients.
Journal ArticleDOI
Production of Shigella dysenteriae Type 1-Like Cytotoxin by Escherichia coli
TL;DR: Strains of Escherichia coli previously implicated or proven to be causes of diarrhea were examined for production of a toxin similar to that of Shigella dysenteriae type 1 (Shiga), suggesting that Shiga-like toxin may be another heretofore undiscovered factor in the pathogenesis of diarrhea caused by some E. coli strains.
Journal ArticleDOI
A Point-Source Outbreak of Campylobacteriosis Associated with Consumption of Raw Milk
TL;DR: After a one-day field trip to a Minnesota farm, 22 (45%) of 49 third-grade students and three (14%) of 21 adult chaperones developed campylobacteriosis and excreted the organism for at least two weeks, but less than six weeks.
Journal ArticleDOI
Related vibrio in stools
TL;DR: A systematic search for vibrio in the stools of 1,000 children without diarrhea revealed 13 carriers, and by means of a filtration technique for coproculture, relatively easy to isolate related vibrios from stool samples, using a medium containing antibiotics.
Related Papers (5)
The genome sequence of the food-borne pathogen Campylobacter jejuni reveals hypervariable sequences
Julian Parkhill,Brendan W. Wren,Karen Mungall,Julian M. Ketley,Carol Churcher,D. Basham,Tracey Chillingworth,Robert L. Davies,Theresa Feltwell,S. Holroyd,Kay Jagels,Andrey V. Karlyshev,Sharon Moule,Mark J. Pallen,Charles W. Penn,Michael A. Quail,Marie-Adèle Rajandream,Kim Rutherford,A. H. M. van Vliet,Sally Whitehead,Bart Barrell +20 more