Journal ArticleDOI
Experimental vaccine protection against feline immunodeficiency virus.
Janet K. Yamamoto,Takiko Okuda,Christopher D. Ackley,Harry Louie,Erin Pembroke,Howard Zochlinski,Robert J. Munn,Murray B. Gardner +7 more
TLDR
The results indicate that vaccine prophylaxis against natural FIV infection should be achievable and enhance optimism of the prospect of developing an effective AIDS vaccine for humans.Abstract:Â
Infection of domestic cats with the feline immunodeficiency virus (FIV) represents an important veterinary health problem and a useful animal model for the development of vaccines against acquired immunodeficiency syndrome (AIDS). Two experimental FIV vaccines have been developed; one consisting of fixed infected cells (Vaccine 1), the other of inactivated whole virus (Vaccine 2). After 4-6 immunizations over 2-5 months, both vaccines induced a strong FIV-specific immune response including neutralizing antibody and T-cell proliferation. Vaccine 1 protected 6 of 9 and Vaccine 2 protected 5 of 6 recipient cats against any detectable infection with a low dose (10 animal ID50) of FIV given intraperitoneally 2 weeks after the final boost. One additional cat in each vaccine group had a transient infection at 5-7 weeks postchallenge following which virus could no longer be detected. Thus, a total of 13 of 15 vaccinated cats were protected against persistent infection. By contrast, 13 of 13 controls were persistently infected by this challenge. The infected cell vaccine failed to protect against a higher dose (5 x 10(4) ID50) of FIV. These results indicate that vaccine prophylaxis against natural FIV infection should be achievable and enhance optimism of the prospect of developing an effective AIDS vaccine for humans.read more
Citations
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Journal ArticleDOI
Feline immunodeficiency virus: an interesting model for AIDS studies and an important cat pathogen.
Mauro Bendinelli,Mauro Pistello,S Lombardi,Alessandro Poli,Carlo Garzelli,Donatella Matteucci,Luca Ceccherini-Nelli,Gino Malvaldi,F. Tozzini +8 more
TL;DR: It is concluded that in many respects FIV is an ideal model for AIDS studies because its susceptibility to antiviral agents is similar to that of HIV, thus providing a valuable system for in vivo preclinical evaluation of therapies.
Journal ArticleDOI
Fusion-Competent Vaccines: Broad Neutralization of Primary Isolates of HIV
Rachel A. LaCasse,Kathryn E. Follis,Meg Trahey,John D. Scarborough,Dan R. Littman,Jack H. Nunberg +5 more
TL;DR: "fusion-competent"
Journal ArticleDOI
FIV infection of the domestic cat: an animal model for AIDS
TL;DR: It is shown that the induction of protective immunity to FIV infection using inactivated virus vaccines offers hope for the development of a successful vaccine for AIDS.
Journal ArticleDOI
Nucleotide sequence of feline immunodeficiency virus: classification of Japanese isolates into two subtypes which are distinct from non-Japanese subtypes.
TL;DR: Phylogenetic analyses of complete env gene sequences demonstrate that worldwide isolates are classified into three subtypes: Japanese TM2, Japanese Shizuoka, and non-Japanese subtypes (U.S. and European isolates), with 20% amino acid distances from each other, which indicates that an evolutionary radiation of these three sub types of FIV occurred at approximately the same time.
Journal ArticleDOI
Enhancement of feline immunodeficiency virus infection after immunization with envelope glycoprotein subunit vaccines.
Kees H.J. Siebelink,Edwin Tijhaar,Robin C. Huisman,Willem Huisman,A. de Ronde,I.H. Darby,M.J. Francis,Guus F. Rimmelzwaan,Albert D. M. E. Osterhaus +8 more
TL;DR: In this article, the authors showed that immunization with recombinant vaccinia virus (rVV)-expressed glycoprotein of FIV results in enhanced infectivity of cats.
References
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Journal Article
T Cell Growth Factor: Parameters of Production and a Quantitative Microassay for Activity
TL;DR: This highly reproducible, quantitative assay for T cell growth factor (TCGF), based upon the tritiated-thymidine incorporation of continuous murine tumor-specific cytotoxic T cell lines (CTLL), has revealed that T lymphocytes are required for its production.
Journal ArticleDOI
Isolation of a T-lymphotropic virus from domestic cats with an immunodeficiency-like syndrome.
TL;DR: A highly T-lymphotropic virus was isolated from cats in a cattery in which all the animals were seronegative for feline leukemia virus, and appears to be antigenically distinct from human immunodeficiency virus.
Journal ArticleDOI
Protection of chimpanzees from infection by HIV-1 after vaccination with recombinant glycoprotein gp120 but not gp160
Phillip W. Berman,Tim Gregory,Lavon Riddle,Gerald R. Nakamura,Mark Champe,James P. Porter,Florian M. Wurm,Robert D. Hershberg,Cobb Ek,Jorg W. Eichberg +9 more
TL;DR: It is demonstrated that recombinant gp120, formulated in an adjuvant approved for human use, can elicit protective immunity against a homologous strain of HIV-1.
Journal ArticleDOI
A formalin-inactivated whole SIV vaccine confers protection in macaques
Michael Murphey-Corb,Louis N. Martin,Billie Davison-Fairburn,Ronald C. Montelaro,Mark A. Miller,Melanie West,Susumu Ohkawa,Gary B. Baskin,Jing Yu Zhang,Scott D. Putney,Anthony C. Allison,Deborah A. Eppstein +11 more
TL;DR: Results demonstrate that a whole virus vaccine is highly effective in inducing immune responses that can protect against lentivirus infection and AIDS-like disease.
Journal Article
Epidemiologic and clinical aspects of feline immunodeficiency virus infection in cats from the continental United States and Canada and possible mode of transmission.
Janet K. Yamamoto,H. Hansen,E. W. Ho,T. Y. Morishita,T. Okuda,T. R. Sawa,R. M. Nakamura,Niels C Pedersen +7 more
TL;DR: The epidemiologic features of feline immunodeficiency virus (FIV) infection were evaluated in 2,765 cats from the United States and Canada and there was a pronounced linkage between FIV and feline syncytium-forming virus (FeSFV) infections.