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Brian J. Willett

Researcher at University of Glasgow

Publications -  143
Citations -  4682

Brian J. Willett is an academic researcher from University of Glasgow. The author has contributed to research in topics: Feline immunodeficiency virus & Virus. The author has an hindex of 33, co-authored 121 publications receiving 3640 citations. Previous affiliations of Brian J. Willett include Scripps Research Institute.

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Shared usage of the chemokine receptor CXCR4 by the feline and human immunodeficiency viruses.

TL;DR: It is demonstrated that cell culture-adapted strains of FIV are able to use the alpha-chemokine receptor CXCR4 for cell fusion, suggesting a close evolutionary link between FIV and HIV and a common mechanism of infection involving an interaction between the virus and a member of the seven-transmembrane domain chemokine receptors family of molecules.
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SARS-CoV-2 Omicron is an immune escape variant with an altered cell entry pathway

Brian J. Willett, +672 more
- 07 Jul 2022 - 
TL;DR: In this article , the authors demonstrate substantial evasion of neutralization by Omicron BA.1 and BA.2 variants in vitro using sera from individuals vaccinated with ChAdOx1, BNT162b2 and mRNA-1273.529.
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Use of CD134 as a primary receptor by the feline immunodeficiency virus.

TL;DR: A primary receptor for FIV is identified as CD134 (OX40), a T cell activation antigen and costimulatory molecule that promotes viral binding and renders cells permissive for viral entry, productive infection, and syncytium formation.
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FIV infection of the domestic cat: an animal model for AIDS

TL;DR: It is shown that the induction of protective immunity to FIV infection using inactivated virus vaccines offers hope for the development of a successful vaccine for AIDS.