Journal ArticleDOI
Exploration of the mechanism of Zisheng Shenqi decoction against gout arthritis using network pharmacology
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TLDR
The PPI network, GO enrichment analysis and KEGG pathway enrichment analysis suggested that ZSD can exerte anti-inflammatory and analgesic effects on the treatment of GA by reducing decreasing inflammatory reaction, alleviating ROS accumulation, and attenuating pain.About:
This article is published in Computational Biology and Chemistry.The article was published on 2021-02-01. It has received 30 citations till now. The article focuses on the topics: KEGG & GeneCards.read more
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Elaborate the Mechanism of Ancient Classic Prescriptions (Erzhi Formula) in Reversing GIOP by Network Pharmacology Coupled with Zebrafish Verification
Zhihui Cai,Huajun Wang,Junkang Jiang,Shichang Xiao,Jianpeng Xiao,Jinjin He,Zihan Zhao,Jiangning Yin +7 more
TL;DR: Erzhi formula (EZF) can promote bone formation and reversed GIOP through “multicomponent/multitarget/multipathway” and the medium dose of EZF may be the most suitable concentration for the treatment of GIOP in zebrafish model.
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Efficacy and Safety of Qinpi Tongfeng Formula Combined with Bloodletting Therapy in the Treatment of Acute Gouty Arthritis: A Study Protocol for a Randomized Controlled Trial
TL;DR: The results of this study will provide reliable clinical evidence for the clinical use of QPTFF combined with bloodletting in the treatment of AGA.
Journal ArticleDOI
Myrtenal and β-caryophyllene oxide screened from Liquidambaris Fructus suppress NLRP3 inflammasome components in rheumatoid arthritis.
TL;DR: In this paper, the active ingredients of liquidambaris fructus (LF) were investigated using network pharmacology and molecular docking methods, and their inhibition of NLRP3 inflammasome activation was verified in the human rheumatoid arthritis fibroblast-like synovial cells (RA-FLS) model.
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Integrated Chemical Molecular Docking with Network Pharmacology to Study the Molecular Mechanism of JianPi YiQi BuSui Method for Treating Myasthenia Gravis
Yibin Zhang,Yunus Emre Genç,Baitong Wang,Peng Xu,Zhiguo Lv,Dongmei Zhang,Qi Lu,Jing Lu,Li Jiang,Qingxia Huang,Ying Zhang,Tianye Lan,Jian Wang +12 more
TL;DR: The pharmacodynamic basis and action mechanism of JPYQBSM in the treatment of myasthenia gravis were predicted by computer network pharmacological technology and molecular docking technology of chemical composition.
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Integrated chemical molecular docking with network pharmacology to study the molecular mechanism of JianPi YiQi BuSui method for treating myasthenia gravis
TL;DR: Wang et al. as discussed by the authors provided new insights into specific mechanisms underlying JPYQBSM therapeutic effects for alleviating myasthenia gravis (MG), a chronic autoimmune neuromuscular disorder, which remains challenging due to side effects associated with modern medications which was used to treat the disease.
References
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The STRING database in 2017: quality-controlled protein-protein association networks, made broadly accessible.
Damian Szklarczyk,John H. Morris,Helen Cook,Michael Kuhn,Stefan Wyder,Milan Simonovic,Alberto Santos,Nadezhda Tsankova Doncheva,Alexander Roth,Peer Bork,Lars Juhl Jensen,Christian von Mering +11 more
TL;DR: In the latest version 10.5 of STRING, the biggest changes are concerned with data dissemination: the web frontend has been completely redesigned to reduce dependency on outdated browser technologies, and the database can now also be queried from inside the popular Cytoscape software framework.
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Gout-associated uric acid crystals activate the NALP3 inflammasome
TL;DR: It is shown that MSU and CPPD engage the caspase-1-activating NALP3 (also called cryopyrin) inflammasome, resulting in the production of active interleukin (IL)-1β and IL-18 in mice deficient in the IL-1β receptor.
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TCMSP: a database of systems pharmacology for drug discovery from herbal medicines.
Jinlong Ru,Peng Li,Wang Jinan,Wei Zhou,Bohui Li,Chao Huang,Pidong Li,Zihu Guo,Weiyang Tao,Yinfeng Yang,Xue Xu,Yan Li,Yonghua Wang,Ling Yang +13 more
TL;DR: The particular strengths of TCMSP are the composition of the large number of herbal entries, and the ability to identify drug-target networks and drug-disease networks, which will help revealing the mechanisms of action of Chinese herbs, uncovering the nature ofTCM theory and developing new herb-oriented drugs.
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The NLRP3 Inflammasome: A Sensor for Metabolic Danger?
TL;DR: It is proposed that the NLRP3 inflammasome contributes to the pathogenesis of T2DM and gout by functioning as a sensor for metabolic stress.
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NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux
TL;DR: In this paper, the authors identify NEK7, a member of the family of mammalian NIMA-related kinases (NEK proteins), as an NLRP3-binding protein that acts downstream of potassium efflux to regulate IL-1β and IL-18 proteins.