Exposure of CuO Nanoparticles Contributes to Cellular Apoptosis, Redox Stress, and Alzheimer's Aβ Amyloidosis.
TLDR
Evidence is provided that CuONP induces neuronal cell apoptosis, discerns a likely p53-dependent apoptosis pathway and builds out the relationship between nanoparticles and Alzheimer’s disease through the involvement of reactive oxygen species (ROS) and increased Aβ levels in SH-SY5Y and H4 cells.Abstract:
Fe2O3, CuO and ZnO nanoparticles (NP) have found various industrial and biomedical applications. However, there are growing concerns among the general public and regulators about their potential environmental and health impacts as their physio-chemical interaction with biological systems and toxic responses of the latter are complex and not well understood. Herein we first reported that human SH-SY5Y and H4 cells and rat PC12 cell lines displayed concentration-dependent neurotoxic responses to insults of CuO nanoparticles (CuONP), but not to Fe2O3 nanoparticles (Fe2O3NP) or ZnO nanoparticles (ZnONP). This study provides evidence that CuONP induces neuronal cell apoptosis, discerns a likely p53-dependent apoptosis pathway and builds out the relationship between nanoparticles and Alzheimer's disease (AD) through the involvement of reactive oxygen species (ROS) and increased Aβ levels in SH-SY5Y and H4 cells. Our results implicate that exposure to CuONP may be an environmental risk factor for AD. For public health concerns, regulation for environmental or occupational exposure of CuONP are thus warranted given AD has already become a pandemic.read more
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Antimicrobial Nano-Agents: The Copper Age.
TL;DR: In this paper, the authors present a critical review on the state of the art regarding the in vitro and in vivo evaluations of the antimicrobial activity of copper-based nanoparticles together with absorption, distribution, metabolism, excretion, and toxicity assessments.
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Exposure to CuO Nanoparticles Mediates NFκB Activation and Enhances Amyloid Precursor Protein Expression.
Xiaoyang Mou,Alexander Pilozzi,Breeya A Tailor,Jing Yi,Catherine M. Cahill,Jack T. Rogers,Xudong Huang +6 more
TL;DR: A low dose of CuONPs effectively activated the NFκB signaling pathway and increased APP expression and the inhibition of p65 expression using siRNA abolished CuONP-mediated APP expression, suggesting thatNFκB-regulated APP expression in response to CuONp exposure may be associated with AD pathology.
Journal ArticleDOI
Nuclear Factor kappa B activation by Ag, Au nanoparticles, CdTe quantum dots or their binary mixtures in HepG2 cells.
Lucyna Kapka-Skrzypczak,Sylwia Męczyńska-Wielgosz,Magdalena Matysiak-Kucharek,Magdalena Czajka,Krzysztof Sawicki,Marcin Kruszewski,Kamil Brzóska +6 more
TL;DR: Comparison of the NF-κB binding activity induced by the mixtures of NPs suggests that in some cases NF-πA binding activity might differ from that observed for the NPs alone, suggesting a similar mode of action.
Journal ArticleDOI
Copper Oxide Nanoparticles Exhibit Cell Death Through Oxidative Stress Responses in Human Airway Epithelial Cells: a Mechanistic Study
Nida N. Farshori,Maqsood A. Siddiqui,Mai M. Al-Oqail,Ebtesam S. Al-Sheddi,Shaza M. Al-Massarani,Maqusood Ahamed,Javed Ahmad,Abdulaziz A. Al-Khedhairy +7 more
TL;DR: It is demonstrated that CuONP can cause apoptosis in HEp-2 cells via oxidative stress; therefore, CuONPs may pose a risk to human health and should be handled and used with caution.
Journal ArticleDOI
The Potential Roles of Redox Enzymes in Alzheimer's Disease: Focus on Thioredoxin.
TL;DR: In this article, the role of the third redox enzyme thioredoxin (Trx), an important multifunctional protein regulating cellular redox status, has been discussed.
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