Journal ArticleDOI
Expression of 17β-hydroxysteroid dehydrogenase type 1 in gastric cancer.
Bartosz Adam Frycz,Dawid Murawa,Maciej Wysocki-Borejsza,Ryszard Marciniak,Paweł Murawa,Michał Drews,Paweł P. Jagodziński +6 more
TLDR
In this article, the effect of 5-Aza-2′-deoxycytidine (5-dAzaC) on the methylation status of HSD17B1 and its expression and conversion of E1 to E2 in HGC-27 and EPG 85-257 GC cells was investigated.About:
This article is published in Biomedicine & Pharmacotherapy.The article was published on 2013-09-01. It has received 13 citations till now. The article focuses on the topics: DNA methylation & DNA demethylation.read more
Citations
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Blocking oestradiol synthesis pathways with potent and selective coumarin derivatives.
Sanna Niinivehmas,Pekka A. Postila,Sanna Rauhamäki,Elangovan Manivannan,Sami Kortet,Mira Ahinko,Pasi Huuskonen,Niina Nyberg,Pasi Koskimies,Sakari Lätti,Elina Multamäki,Risto O. Juvonen,Hannu Raunio,Markku Pasanen,Juhani Huuskonen,Olli T. Pentikäinen +15 more
TL;DR: Coumarin core can be tailored with specific ring and polar moiety substitutions to block either the sulphatase pathway or the aromatase pathways for treating breast cancer and endometriosis.
Journal ArticleDOI
The clinicopathologic significance of estrogen receptors in human gastric carcinoma
TL;DR: In a recent study, it was indicated that sex steroid hormones and estrogen receptors are partly involved in gastric cancer but their clinicopathological significance still needs further investigation.
Journal ArticleDOI
Increased expression of 17-beta-hydroxysteroid dehydrogenase type 1 in non-small cell lung cancer.
Hanna Drzewiecka,Bartłomiej Gałęcki,Donata Jarmołowska-Jurczyszyn,Andrzej Kluk,Wojciech Dyszkiewicz,Paweł P. Jagodziński +5 more
TL;DR: Increased expression of HSD17B1 in NSCLC may contribute to an elevated intratissue level of E2 and consequently may support the development and spread of cancer.
Journal ArticleDOI
Characteristics and sex dimorphism of 17β-hydroxysteroid dehydrogenase family genes in the olive flounder Paralichthys olivaceus
Congcong Zou,Lijuan Wang,Yuxia Zou,Zhihao Wu,Wenxiang Wang,Shaoshuai Liang,Ling Wang,Feng You +7 more
TL;DR: The characteristics of the flounder Hsd17b in subfamily are introduced, which contribute to the understanding of the regulation of sex steroid hormone synthesis in fish gonadal development.
Journal ArticleDOI
Role of hydroxysteroid (17beta) dehydrogenase type 1 in reproductive tissues and hormone-dependent diseases
TL;DR: The role of the HSD17B1 enzyme in hormone-dependent diseases in women as evidenced by preclinical studies is summarized.
References
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Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
TL;DR: A new method of total RNA isolation by a single extraction with an acid guanidinium thiocyanate-phenol-chloroform mixture is described, providing a pure preparation of undegraded RNA in high yield and can be completed within 4 h.
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Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008.
TL;DR: The results for 20 world regions are presented, summarizing the global patterns for the eight most common cancers, and striking differences in the patterns of cancer from region to region are observed.
Book
Cancer Incidence in Five Continents
Freddie Bray,J. Ferlay,Mathieu Laversanne,David H. Brewster,C. Gombe Mbalawa,B. Kohler,Marion Piñeros,Eva Steliarova-Foucher,Rajaraman Swaminathan,Sebastien Antoni,Isabelle Soerjomataram,David Forman +11 more
TL;DR: The aim of this study was to establish a database of histological groups and to provide a level of consistency and quality of data that could be applied in the design of future registries.
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Guideline to reference gene selection for quantitative real-time PCR.
Aleksandar Radonic,Stefanie Thulke,Ian M. Mackay,Olfert Landt,Wolfgang Siegert,Andreas Nitsche,Andreas Nitsche +6 more
TL;DR: In this paper, quantitative real-time PCR was used to determine the mRNA transcription profiles of 13 putative reference genes, comparing their transcription in 16 different tissues and in CCRF-HSB-2 cells stimulated with 12-Otetradecanoylphorbol-13-acetate and ionomycin.
Journal ArticleDOI
Epidemiology of gastric cancer
TL;DR: Diverging trends in the incidence of gastric cancer by tumor location suggest that they may represent two diseases with different etiologies, and strategies for primary prevention are discussed.
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Blocking 17β‐hydroxysteroid dehydrogenase type 1 in endometrial cancer: a potential novel endocrine therapeutic approach
Gonda Konings,Gonda Konings,Karlijn M. C. Cornel,Karlijn M. C. Cornel,Sofia Xanthoulea,Sofia Xanthoulea,Bert Delvoux,Bert Delvoux,Margaretha A. Skowron,Loes F. S. Kooreman,Loes F. S. Kooreman,Pasi Koskimies,Camilla Krakstad,Camilla Krakstad,Helga B. Salvesen,Helga B. Salvesen,Kim van Kuijk,Kim van Kuijk,Yannick Schrooders,Yannick Schrooders,Marc Vooijs,Arjan J. Groot,Marlies Y. Bongers,Marlies Y. Bongers,Roy F.P.M. Kruitwagen,Roy F.P.M. Kruitwagen,Andrea Romano,Andrea Romano +27 more