Journal ArticleDOI
Expression profiles of genes involved in apoptosis and selenium metabolism in articular cartilage of patients with Kashin-Beck osteoarthritis.
Shi Xun Wu,Weizhuo Wang,Feng Zhang,Cuiyan Wu,Bannel S. Dennis,Chengjuan Qu,Yidong Bai,Xiong Guo +7 more
Reads0
Chats0
TLDR
The results suggest that abnormal regulation of selenium metabolism and apoptosis through the MYC mediated signaling pathway contributes to the pathogenesis of KBD, but the relationship between apoptosis gene and seenium gene was not found.About:
This article is published in Gene.The article was published on 2014-02-10. It has received 18 citations till now. The article focuses on the topics: Kashin–Beck disease & Microarray analysis techniques.read more
Citations
More filters
Journal ArticleDOI
Recent advances in the research of an endemic osteochondropathy in China: Kashin-Beck disease
TL;DR: Kashin-Beck disease (KBD) is an endemic chronic osteochondral disease, which has a high prevalence and morbidity in the Eastern Siberia of Russia, and in the broad diagonal, northern-east to southern-west belt in China and North Korea.
Journal ArticleDOI
Systems Biology of Selenium and Complex Disease.
Huimin Ying,Yan Zhang +1 more
TL;DR: Recent progress in large-scale and systematic analyses of the relationship between selenium status or selenoproteins and several complex diseases are reviewed, mainly including population-based cohort studies and meta-analyses, genetic association studies, and some other omics-based studies.
Journal ArticleDOI
Selenium Nanoparticles Dispersed in Phytochemical Exert Anti-Inflammatory Activity by Modulating Catalase, GPx1, and COX-2 Gene Expression in a Rheumatoid Arthritis Rat Model.
TL;DR: The results collectively suggest that SeNPs dispersed in CA can be an effective therapeutic agent for inflammatory disorders like acute gouty arthritis.
Journal ArticleDOI
CRISPR/Cas9 mediated generation of stable chondrocyte cell lines with targeted gene knockouts; analysis of an aggrecan knockout cell line
TL;DR: A stable RCS cell line (RCS Cas9) expressing the nuclease Cas9 that enables the editing of any target gene or non-coding RNA by simple transfection with a guide RNA is generated, providing new understanding of aggrecan function.
Journal ArticleDOI
Selenium and Iodine Levels in Subjects with Kashin-Beck Disease: a Meta-analysis.
TL;DR: The levels of selenium, but not iodine were significantly lower in subjects with KBD than that in healthy controls, and Selenium deficiency might be associated with the risk of KBD.
References
More filters
Journal ArticleDOI
Statistical analysis of real-time PCR data
TL;DR: Data quality control and analysis procedures presented here provide statistical elements for the estimation of the relative expression of genes using real-time PCR.
Journal ArticleDOI
Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics.
Anthony Letai,Michael C. Bassik,Loren D. Walensky,Mia D. Sorcinelli,Solly Weiler,Stanley J. Korsmeyer +5 more
TL;DR: A two-class model for BH3 domains is supported: BID-like domains that "activate" BAX, BAK and BAD-like domain that "sensitize" by occupying the pocket of antiapoptotic members.
Journal ArticleDOI
Apoptotic signaling by c-MYC
TL;DR: An overview of the function of the tumor suppressor gene product p53 in the c-MYC-mediated apoptotic response and how c- MYC amplifies the intrinsic mitochondrial pathway and triggers and/or amplifying the death receptor pathways is provided.
Journal ArticleDOI
Kashin–Beck Osteoarthropathy in Rural Tibet in Relation to Selenium and Iodine Status
Rodrigo Moreno-Reyes,C. Suetens,Françoise Mathieu,Françoise Begaux,Dun Zhu,Maria T. Rivera,Marleen Boelaert,Jean Neve,Noemi Perlmutter,Jean Vanderpas +9 more
TL;DR: In areas where severe selenium deficiency is endemic, iodine deficiency is a risk factor for Kashin-Beck disease and low urinary iodine, high serum thyrotropin, and low serum thyroxine-binding globulin values were associated with an increased risk of Kashin -Beck disease, but a low serum seenium concentration was not.
Journal ArticleDOI
Selenium and Inflammation: Underlying Anti-inflammatory Mechanisms
TL;DR: In patients with severe sepsis, characterized by an increase in reactive oxygen species and low endogenous anti-oxidative capacity, as well as in patients with systemic inflammatory response syndrome, Se supplementation may reduce mortality and improve the clinical outcome, respectively.
Related Papers (5)
Combined Transcriptome and Proteome Leukocyte's Profiling Reveals Up-Regulated Module of Genes/Proteins Related to Low Density Neutrophils and Impaired Transcription and Translation Processes in Clinical Sepsis
Giuseppe Gianini Figueirêdo Leite,Bianca Lima Ferreira,Alexandre Keiji Tashima,Erika S. Nishiduka,Edecio Cunha-Neto,Milena Karina Coló Brunialti,Murillo Santucci Cesar de Assunção,Luciano Cesar Pontes Azevedo,Flávio Geraldo Resende Freitas,Tom van der Poll,Brendon P. Scicluna,Brendon P. Scicluna,Reinaldo Salomão +12 more