Journal ArticleDOI
Extended interhuman transmission of monkeypox in a hospital community in the republic of the congo, 2003
Lynne A. Learned,Mary G. Reynolds,Demole Wassa Wassa,Yu Li,Victoria A. Olson,Kevin L. Karem,Linda L. Stempora,Zach Braden,Richard Kline,Anna Likos,F Libama,Henri Moudzeo,Jean Daniel Bolanda,Paul Tarangonia,Paul Boumandoki,Pierre Formenty,Joseph M. Harvey,Inger K. Damon +17 more
TLDR
This report describes the first reported outbreak of human monkeypox in the Republic of Congo, with up to six sequential transmissions of monkeypox virus from person to person hypothesized to have occurred, making this the longest uninterrupted chain of humanmonkeypox fully documented to date.Abstract:
This report describes the first reported outbreak of human monkeypox in the Republic of Congo. Eleven confirmed and probable monkeypox cases were observed during this outbreak, all were less than 18 years old, and most resided on the grounds of the Government Hospital in Impfondo. Molecular, virologic, and serologic, and diagnostic assays were used to detect evidence of monkeypox (or orthopox) virus infection in individuals with striking dermatologic and other clinical manifestations. The majority of cases in this outbreak experienced significant, symptomatic illnesses; there was one death, possibly involving secondary complications, and one instance of profound sequelae. Up to six sequential transmissions of monkeypox virus from person to person are hypothesized to have occurred, making this the longest uninterrupted chain of human monkeypox fully documented to date. The pattern of sustained human-to-human transmission observed during this outbreak may influence our current perception of the capacity for this zoonotic virus to adapt to humans.read more
Citations
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Journal ArticleDOI
2007 Guideline for Isolation Precautions: Preventing Transmission of Infectious Agents in Health Care Settings.
TL;DR: The ability of hospital ventilation systems to filter Aspergillus and other fungi following a building implosion and the impact of bedside design and furnishing on nosocomial infections are investigated.
Guideline for isolation precautions: preventing transmission of infectious agents in healthcare settings 2007.
TL;DR: The ability of hospital ventilation systems to filter Aspergillus and other fungi following a building implosion and the impact of bedside design and furnishing on nosocomial infections are investigated.
Journal ArticleDOI
The changing epidemiology of human monkeypox—A potential threat? A systematic review
TL;DR: A systematic review of peer-reviewed and grey literature on how monkeypox epidemiology has evolved, with particular emphasis on the number of confirmed, probable, and/or possible cases, age at presentation, mortality, and geographical spread was conducted in this article .
Journal ArticleDOI
Clinical features and management of human monkeypox: a retrospective observational study in the UK
Yi Wang,V. V. Kuryliak +1 more
TL;DR: In this paper , the authors report the clinical features, longitudinal virological findings, and response to off-label antivirals in seven patients with monkeypox who were diagnosed in the UK between 2018 and 2021, identified through retrospective case-note review.
Journal ArticleDOI
Clinical features and management of human monkeypox: a retrospective observational study in the UK
Hugh Adler,Susan M Gould,Paul Hine,Luke B Snell,Waison Wong,Catherine F Houlihan,Jane Osborne,Tommy Rampling,Mike B.J. Beadsworth,Christopher J A Duncan,Jake Dunning,Tom Fletcher,Ewan Hunter,Michael R. Jacobs,Saye Khoo,William Newsholme,David Porter,R Jefferson Porter,L. Ratcliffe,Matthias Schmid,Malcolm G Semple,Anne Tunbridge,Tom Wingfield,Nicholas Price,Michael Abouyannis,Asma Al-Balushi,Stephen Aston,Robert Ball,Nicholas J. Beeching,Tom Blanchard,Ffion Carlin,Geraint Davies,Angela Gillespie,Scott Rory Hicks,Marie-Claire Hoyle,C. Ilozue,L. Mair,Suzanne Marshall,Ann Neary,Emmanuel Nsutebu,Samantha Parker,Hannah Ryan,Lance Turtle,Christie A. Smith,Jon Jurriaan van Aartsen,N. Walker,Stephen D. Woolley,A. Chawla,Ian J Hart,Anna Smielewska,Elizabeth Joekes,Cathryn Benson,Cheryl Brindley,Urmi Das,Chin Kien Eyton-Chong,Claire Gnanalingham,Claire Halfhide,Beatriz Larru,Sarah Mayell,Joanna McBride,Claire Oliver,Princy Gupta and Satya Paul,Andrew Riordan,L. S. Sridhar,Megan Storey,Audrey Abdul,Jennifer Abrahamsen,Breda Athan,Sanjay Bhagani,Colin S Brown,Oliver L. Carpenter,Ian Cropley,Kerrie Frost,Susan Hopkins,Jessie Briggs Joyce,Lucy E Lamb,Adrian Lyons,Tabitha Mahungu,Stephen Mepham,Edina Mukwaira,Alison Rodger,Caroline Taylor,Simon Warren,Alan Williams,Debbie Levitt,D.O. Allen,Jill Dixon,Adam Evans,Paul McNicholas,Brendan A I Payne,David Price,Ulrich Schwab,Allison Sykes,Yusri Taha,Margaret May Ward,Marieke Emonts,Stephen Owens,A Botgros,Sam Douthwaite,Anna Goodman,Akish Luintel,Eithne MacMahon,G. Nebbia,Geraldine O’Hara,Joseph Parsons,Ashwin Sen,Daniel R Stevenson,Tadgh Sullivan,Usman Taj,Claire van Nipsen tot Pannerden,Helen Winslow,Ewa Zatyka,Ekene Alozie-Otuka,C. Beviz,Yusupha Ceesay,Latchmin Gargee,M. Kabia,H. Mitchell,Shona Perkins,Mingaile Sasson,Kamal Sehmbey,Federico Tabios,Neil Wigglesworth,Emma Aarons,Tim Brooks,Matthew Dryden,Jenna Furneaux,Barry C. Gibney,Jennifer L. Small,Elizabeth C Truelove,Clare Warrell,Richard W. Firth,Gemma Louise Hobson,Christopher Johnson,A. Dewynter,S.G. Nixon,Oliver Spence,Joachim Jakob Bugert,Dennis E. Hruby +138 more
TL;DR: The longitudinal clinical course of monkeypox in a high-income setting, coupled with viral dynamics, and any adverse events related to novel antiviral therapies are described, to highlight the urgent need for prospective studies of antivirals for this disease.
References
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Journal ArticleDOI
The detection of monkeypox in humans in the Western Hemisphere.
Kurt D. Reed,John W. Melski,Mary Beth Graham,Russell L. Regnery,Mark J. Sotir,Mark V. Wegner,James J. Kazmierczak,Erik J. Stratman,Yu Li,Janet A. Fairley,Geoffrey R. Swain,Victoria A. Olson,Elizabeth K. Sargent,Sue C. Kehl,Michael Frace,Richard Kline,Seth Foldy,Jeffrey P. Davis,Inger K. Damon +18 more
TL;DR: This investigation documents the isolation and identification of monkeypox virus from humans in the Western Hemisphere and suggests that the prairie dogs had been exposed to at least one species of rodent recently imported into the United States from West Africa.
Journal ArticleDOI
The role of evolution in the emergence of infectious diseases
TL;DR: It is shown that an increase in R0, even when insufficient to generate an epidemic, nonetheless increases the number of subsequently infected individuals and subsequent disease emergence can increase markedly.
Journal Article
A human infection caused by monkeypox virus in Basankusu Territory, Democratic Republic of the Congo.
I. D. Ladnyj,P. Ziegler,E. Kima +2 more
TL;DR: Clinical and epidemiological information on a patient with smallpox-like disease, from whom a monkeypox- like virus was isolated, is presented, which was the first recognized human monkeypox case in medical history.
Journal ArticleDOI
The Transmission Potential of Monkeypox Virus in Human Populations
TL;DR: The findings support the recommendation of the Global Commission for the Certification of Smallpox Eradication to cease routine smallpox vaccination in monkeypox endemic areas, but to encourage continued epidemiological surveillance.
Journal ArticleDOI
Immunogenicity of a highly attenuated MVA smallpox vaccine and protection against monkeypox
Patricia L. Earl,Jeffrey L. Americo,Linda S. Wyatt,Leigh Anne Eller,J. Charles Whitbeck,Gary H. Cohen,Roselyn J. Eisenberg,Chris Hartmann,David L. Jackson,David A. Kulesh,Mark J. Martinez,David M. Miller,Eric M. Mucker,Joshua D. Shamblin,Susan H. Zwiers,John W. Huggins,Peter B. Jahrling,Bernard Moss +17 more
TL;DR: The highly attenuated modified vaccinia virus Ankara (MVA) with the licensed Dryvax vaccine in a monkey model is compared and unimmunized animals developed more than 500 pustular skin lesions and became gravely ill or died, whereas vaccinated animals were healthy and asymptomatic.
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