Fabrication of SnS/TiO2@GO Composite Coated Glassy Carbon Electrode for Concomitant Determination of Paracetamol, Tryptophan, and Caffeine in Pharmaceutical Formulations

TLDR: An electrochemical sensor via incorporating tin sulfide and titanium dioxide on graphene oxide (GO) sheets (SnS/TiO2@GO ternary composite) for their separate and simultaneous determination through cyclic voltammetry and differential pulsevoltammetry techniques holds great promise for identification and quantification of drugs in combination.

Abstract: Designing an electrochemical sensor which is simple, cheap, sensitive, fast, and accurate is inevitable, as it is important in drug quality control, point-of-care diagnosis, and other clinical studies. Sensors for simultaneous determination of paracetamol, tryptophan, and caffeine have not been reported so far, and we report an electrochemical sensor via incorporating tin sulfide (SnS) and titanium dioxide (TiO2) on graphene oxide (GO) sheets (SnS/TiO2@GO ternary composite) for their separate and simultaneous determination through cyclic voltammetry and differential pulse voltammetry techniques. The surface morphology and structural properties of the composite were characterized by analytical techniques. The electrochemical study of SnS/TiO2@GO composite modified glassy carbon electrode (GC-SnS/TiO2@GO) showed high activity toward the oxidation of paracetamol, tryptophan, and caffeine with significant decrease in overpotential due to large surface and high carrier mobility. The peak currents during separa...