Fabrication, Optimization, and Evaluation of Rotigotine-Loaded Chitosan Nanoparticles for Nose-To-Brain Delivery.
Angeline Shak Tzeyung,Shadab,Shadab,Subrat Kumar Bhattamisra,Thiagarajan Madheswaran,Nabil A. Alhakamy,Hibah M. Aldawsari,Ammu Kutty Radhakrishnan +7 more
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TLDR
The results indicated that rotigotine-loaded chitosan nanoparticles provide an efficient carrier for nose-to-brain delivery.Abstract:
The objective of the present study was to develop, optimize, and evaluate rotigotine-loaded chitosan nanoparticles (RNPs) for nose-to-brain delivery. Rotigotine-loaded chitosan nanoparticles were prepared by the ionic gelation method and optimized for various parameters such as the effect of chitosan, sodium tripolyphosphate, rotigotine concentration on particle size, polydispersity index (PDI), zeta potential, and entrapment efficiency. The prepared nanoparticles were characterized using photon correlation spectroscopy, transmission electron microscopy, scanning electron microscopy, atomic force microscopy, fourier-transform infrared spectroscopy, and X-ray diffraction. The developed RNPs showed a small hydrodynamic particle size (75.37 ± 3.37 nm), small PDI (0.368 ± 0.02), satisfactory zeta potential (25.53 ± 0.45 mV), and very high entrapment efficiency (96.08 ± 0.01). The 24-h in vitro release and ex vivo nasal permeation of rotigotine from the nanoparticles were 49.45 ± 2.09% and 92.15 ± 4.74% while rotigotine solution showed corresponding values of 95.96 ± 1.79%and 58.22 ± 1.75%, respectively. The overall improvement ratio for flux and permeability coefficient were found to be 4.88 and 2.67 when compared with rotigotine solution. A histopathological study showed that the nanoparticulate formulation produced no toxicity or structural damage to nasal mucosa. Our results indicated that rotigotine-loaded chitosan nanoparticles provide an efficient carrier for nose-to-brain delivery.read more
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Chitosan-based (Nano)materials for Novel Biomedical Applications.
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Synthesis, Bioapplications, and Toxicity Evaluation of Chitosan-Based Nanoparticles.
TL;DR: A comprehensive overview of recent advances in chitosan derivatives and nanoparticle synthesis, as well as emerging applications in medicine, tissue engineering, drug delivery, gene therapy, and cancer therapy are presented.
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Chitosan Nanoparticles-Insight into Properties, Functionalization and Applications in Drug Delivery and Theranostics.
TL;DR: In this article, a review of chitosan nanoparticles is presented to provide an insight into the chemistry, properties, drug release mechanisms, preparation techniques and the vast evolving landscape of diverse applications across disease categories leading to development of better therapeutics and superior clinical outcomes.
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Potential of Chitosan and Its Derivatives for Biomedical Applications in the Central Nervous System.
Doddy Denise Ojeda-Hernández,Alejandro A. Canales-Aguirre,Jorge Matías-Guiu,Ulises Gómez-Pinedo,Juan Carlos Mateos-Díaz +4 more
TL;DR: This review aims to bring together recent works that highlight the potential of chitosan and its derivatives as adequate biomaterials for applications directed toward the central nervous system.
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Nose to brain delivery of rotigotine loaded chitosan nanoparticles in human SH-SY5Y neuroblastoma cells and animal model of Parkinson's disease.
Subrat Kumar Bhattamisra,Angeline Tzeyung Shak,Lim Wen Xi,Nurul Hasyanazifa Safian,Hira Choudhury,Wei-Meng Lim,Naiyer Shahzad,Nabil A. Alhakamy,Khalid Anwer,Ammu Kutty Radhakrishnan,Shadab +10 more
TL;DR: Results from the animal model of PD show that intranasally-administered RNPs enhanced brain targeting efficiency and drug bioavailability and RNPs for nose-to-brain delivery has significant potential to be developed as a treatment approach for PD.
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