Journal ArticleDOI
Familial Hypercholesterolemia: Screening, diagnosis and management of pediatric and adult patients: Clinical guidance from the National Lipid Association Expert Panel on Familial Hypercholesterolemia
Anne C. Goldberg,Paul N. Hopkins,Peter P. Toth,Christie M. Ballantyne,Daniel J. Rader,Jennifer G. Robinson,Stephen R. Daniels,Samuel S. Gidding,Sarah D. de Ferranti,Matthew K. Ito,Mary P. McGowan,Patrick M. Moriarty,William C. Cromwell,Joyce L. Ross,Paul Ziajka +14 more
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TLDR
This report goes beyond previously published guidelines by providing specific clinical guidance for the primary care clinician and lipid specialist with the goal of improving care of patients with FH and reducing their elevated risk for CHD.About:
This article is published in Journal of Clinical Lipidology.The article was published on 2011-05-01. It has received 560 citations till now. The article focuses on the topics: Familial hypercholesterolemia & Lomitapide.read more
Citations
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Journal ArticleDOI
Referral Patterns and Cascade Screening for Familial Hypercholesterolemia in a Pediatric Lipid Clinic.
TL;DR: Charts of 42 children with familial hypercholesterolemia from a dyslipidemia clinic were reviewed for initial cholesterol screen indication and cascade screening results.
Journal ArticleDOI
Lipoprotein Apheresis
Vijay Bhoj,Bruce S. Sachais +1 more
TL;DR: Lipoprotein apheresis is an extracorporeal therapy whereby apo B-containing lipoproteins (LDL, vLDL and Lp(a)) are selectively removed from the plasma of a patient as discussed by the authors.
Journal Article
Liquorice beverage effect on the pharmacokinetic parameters of atorvastatin, simvastatin, and lovastatin by liquid chromatography-mass spectroscopy/mass spectroscopy
TL;DR: In this paper, the effects of pre-consumption of freshly prepared liquorice beverage (4 ml/kg) on the pharmacokinetic (PK) parameters of (80 mg/kg), simvastatin, and lovastatin in healthy rats plasma were examined.
Journal ArticleDOI
Familial hypercholesterolemia: Detect, treat, and ask about family
TL;DR: Familial hypercholesterolemia is an autosomal dominant disorder that affects the metabolism of low-density lipoprotein cholesterol through mutations in the gene for LDL receptor (LDLR), and less commonly in those for apolipoprotein B, proprotein convertase subtilisin-kexin type 9 (PCSK9), and others.
Journal ArticleDOI
Electronic health records to facilitate continuous detection of familial hypercholesterolemia
Shari Pepplinkhuizen,Shirin Ibrahim,Rutger Vink,Bas Groot,Erik S.G. Stroes,Willem A. Bax,Jan H. Cornel +6 more
TL;DR: It is concluded that automated medical record-based integration of LDL-C, LLT and patient- and family history can provide a crucial signal to facilitate identification of FH patients.
References
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Journal ArticleDOI
Hyperlipidemia in Coronary Heart Disease II. GENETIC ANALYSIS OF LIPID LEVELS IN 176 FAMILIES AND DELINEATION OF A NEW INHERITED DISORDER, COMBINED HYPERLIPIDEMIA
TL;DR: The combined disorder was shown to be genetically distinct from familial hypercholesterolemia and familial hypertriglyceridemia for the following reasons: the distribution pattern of cholesterol and triglyceride levels in relatives of probands was unique.
Journal ArticleDOI
Lipid Screening and Cardiovascular Health in Childhood
TL;DR: The need for prevention of cardiovascular disease by following Dietary Guidelines for Americans and increasing physical activity is reemphasized and the need for pharmacologic agents and indications for treating dyslipidemia in children are reviewed.
Journal ArticleDOI
Efficacy of statins in familial hypercholesterolaemia: a long term cohort study
Jorie Versmissen,Daniëlla M. Oosterveer,Mojgan Yazdanpanah,Joep C. Defesche,Dick C. Basart,Anho H Liem,Jan Heeringa,Jacqueline C.M. Witteman,P. J. Lansberg,John J.P. Kastelein,Eric J.G. Sijbrands +10 more
TL;DR: Lower statin doses than those currently advised reduced the risk of coronary heart disease to a greater extent than anticipated in patients with familial hypercholesterolaemia.
Journal ArticleDOI
Genetic Causes of Monogenic Heterozygous Familial Hypercholesterolemia: A HuGE Prevalence Review
TL;DR: The clinical phenotype of heterozygous familial hypercholesterolemia (FH) is characterized by increased plasma levels of total cholesterol and low density lipoprotein cholesterol, tendinous xanthomata, and premature symptoms of coronary heart disease.
Journal ArticleDOI
Guidelines for the diagnosis and management of heterozygous familial hypercholesterolemia.
TL;DR: These guidelines have been elaborated by a group of international experts with the intention to answer the main questions about heterozygous FH (heFH) subjects that physicians worldwide face in the diagnosis and management of these patients.
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