Journal ArticleDOI
Family history study of the restless legs syndrome.
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TLDR
The results are consistent with a genetic etiology for RLS, but they do not support the presence of one simple, Mendelian-inherited major gene in most RLS families.About:
This article is published in Sleep Medicine.The article was published on 2002-11-01. It has received 107 citations till now. The article focuses on the topics: Population.read more
Citations
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Restless legs syndrome: diagnostic criteria, special considerations, and epidemiology. A report from the restless legs syndrome diagnosis and epidemiology workshop at the National Institutes of Health.
Richard P. Allen,Daniel L. Picchietti,Wayne A. Hening,Claudia Trenkwalder,Arthur S. Walters,Jacques Montplaisi +5 more
TL;DR: Modification of the criteria for the diagnosis of restless legs syndrome is modified to better reflect that increased body of knowledge, as well as to clarify slight confusion with the wording of the original criteria.
Journal ArticleDOI
Restless legs syndrome/Willis-Ekbom disease diagnostic criteria: updated International Restless Legs Syndrome Study Group (IRLSSG) consensus criteria--history, rationale, description, and significance.
Richard P. Allen,Daniel L. Picchietti,Diego Garcia-Borreguero,William G. Ondo,Arthur S. Walters,John W. Winkelman,Marco Zucconi,Raffaele Ferri,Claudia Trenkwalder,Hochang B. Lee +9 more
TL;DR: The IRLSSG consensus criteria for RLS/WED represent an international, interdisciplinary, and collaborative effort intended to improve clinical practice and promote further research.
Journal ArticleDOI
Epidemiology of restless legs syndrome in French adults: A nationwide survey: The INSTANT Study
TL;DR: Restless legs syndrome (RLS) is often underdiagnosed and few subjects receive recommended RLS drug treatment, and the prevalence decreases after the age of 64.
Journal ArticleDOI
MRI-determined regional brain iron concentrations in early- and late-onset restless legs syndrome.
TL;DR: The current MRI results in combination with previous autopsy data support the role of low brain iron in the SN in at least those with early-onset RLS symptoms.
Journal ArticleDOI
Epidemiology of restless legs syndrome: The current status
TL;DR: In summary, epidemiological evidence suggests that RLS is a common neurological disorder-with high impact on many aspects of the life of those affected.
References
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Journal ArticleDOI
The Future of Genetic Studies of Complex Human Diseases
TL;DR: The identification of the genetic basis of complex human diseases such as schizophrenia and diabetes has proven difficult as mentioned in this paper, and Risch and Merikangas proposed that they can best accomplish this goal by combining the power of the human genome project with association studies.
Journal Article
Linkage strategies for genetically complex traits. I. Multilocus models.
TL;DR: It is shown in the second paper of this series that lambda R is the critical parameter in determining power to detect linkage by using affected relative pairs in multilocus models of inheritance.
Journal ArticleDOI
Toward a better definition of the restless legs syndrome
Arthur S. Walters,Michael S. Aldrich,Richard P. Allen,Sonia Ancoli-Israel,David W. Buchholz,Sudhansu Chokroverty,Giorgio Coccagna,Christopher J. Earley,Bruce L. Ehrenberg,T. G. Feest,Wayne A. Hening,Neil B. Kavey,Gilles Lavigne,Joseph F. Lipinski,Elio Lugaresi,Pasquale Montagna,Jacques Montplaisir,Sarah S. Mosko,Wolfgang H. Oertel,Daniel L. Picchietti,Thomas Pollmächer,Renata Shafor,Robert C. Smith,Wenche Telstad,C. Trenkwalder,C. Trenkwalder,Christian von Scheele,J. Catesby Ware,Marco Zucconi +28 more
TL;DR: A large International Restless Legs Syndrome (RLS) Study Group has been formed as discussed by the authors, which has taken upon itself the role of definig the clinical features of the RLS, including sleep disturbance, periodic limb movements in sleep and similar involuntary movements while awake, a normal neurological examination in the idiopathic from, a tendency for the symptoms to be worse in middle to older age, and a family history suggestive of an autosomal dominant mode of inheritance.
Journal ArticleDOI
Clinical, polysomnographic, and genetic characteristics of restless legs syndrome: A study of 133 patients diagnosed with new standard criteria
Jacques Montplaisir,Sylvie Boucher,Gaétan Poirier,Gilles Lavigne,Odile Lapierre,Paul Lespérance +5 more
TL;DR: A strong relationship was found between these complaints and polysomnographic findings; increasing sleep latency and number of awakenings and decreasing sleep efficiency were associated with worsening symptoms.
Journal ArticleDOI
Epidemiology of Restless Legs Symptoms in Adults
TL;DR: The prevalence of restless legs in the general adult population is high and may be associated with decreased well-being, emphasizing the need for further research and greater medical recognition of this condition.
Related Papers (5)
Toward a better definition of the restless legs syndrome
Arthur S. Walters,Michael S. Aldrich,Richard P. Allen,Sonia Ancoli-Israel,David W. Buchholz,Sudhansu Chokroverty,Giorgio Coccagna,Christopher J. Earley,Bruce L. Ehrenberg,T. G. Feest,Wayne A. Hening,Neil B. Kavey,Gilles Lavigne,Joseph F. Lipinski,Elio Lugaresi,Pasquale Montagna,Jacques Montplaisir,Sarah S. Mosko,Wolfgang H. Oertel,Daniel L. Picchietti,Thomas Pollmächer,Renata Shafor,Robert C. Smith,Wenche Telstad,C. Trenkwalder,C. Trenkwalder,Christian von Scheele,J. Catesby Ware,Marco Zucconi +28 more