Journal ArticleDOI
Febrile seizures : recognition and management
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TLDR
The majority of all febrile seizures represent a benign syndrome that does not require extensive testing or long term medication, and those infants and children with this syndrome are identified.Abstract:
The majority of all febrile seizures represent a benign syndrome that does not require extensive testing or long term medication. A careful history of the febrile seizure, family history, developmental history and physical examination can identify those infants and children with this syndrome. While one-third of this group will experience additional febrile seizures, there is no significant increase in the incidence of later epilepsy or neurological sequelae. The parents of these children need to be reassured and educated about this syndrome. They should understand the emergency treatment of seizures and aggressively treat fever. The more difficult task for the physician is to correctly identify those children who experience nonbenign seizures. Careful history and physical examination can accurately identify this group. Further evaluation including neuroimaging, electroencephalogram and developmental assessment may be necessary. In those children with a high risk of later epilepsy, treatment with an antiepileptic drug should be considered.read more
Citations
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Journal ArticleDOI
Clinical Report—Fever and Antipyretic Use in Children
TL;DR: The primary goal of treating the febrile child should be to improve the child's overall comfort rather than focus on the normalization of body temperature, and Pediatricians should also promote patient safety by advocating for simplified formulations, dosing instructions, and dosing devices.
Journal ArticleDOI
The role of inflammation in the development of epilepsy
Amna Z Rana,Alberto E. Musto +1 more
TL;DR: Understanding the neurobiology of inflammation in epileptogenesis will contribute to the development of new biomarkers for better screening of patients at risk for epilepsy and new therapeutic targets for both prophylaxis and treatment of epilepsy.
Journal ArticleDOI
Summary of recommendations for the management of infantile seizures: Task Force Report for the ILAE Commission of Pediatrics.
Jo M. Wilmshurst,William D. Gaillard,Kollencheri Puthenveettil Vinayan,Tammy Tsuchida,Perrine Plouin,Patrick Van Bogaert,Jaime Carrizosa,Maurizio Elia,Dana Craiu,Nebojša Jović,Doug Nordli,Deborah Hirtz,Virginia Wong,Virginia Wong,Tracy A. Glauser,Eli M. Mizrahi,J. Helen Cross +16 more
TL;DR: The report contains recommendations for different levels of care, noting which would be regarded as standard care, compared to optimal care, or “state of the art” interventions, and levels of evidence to support recommendations and statements.
Journal ArticleDOI
Incidence, prevalence and aetiology of seizures and epilepsy in children
Peter Camfield,Carol Camfield +1 more
TL;DR: The incidence and prevalence of epilepsy in children appears to be lower in developed countries and highest in rural areas of underdeveloped countries, and the reasons for these trends are not well established.
Journal ArticleDOI
Microglia-Neuron Communication in Epilepsy.
TL;DR: This review highlights microglial reaction to experimental seizures, discusses microglian control of neuronal activities, and proposes the functions of microglia during acute epileptic phenotypes, delayed neurodegeneration, and aberrant neurogenesis.
References
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Journal ArticleDOI
Physiological and pathophysiological roles of excitatory amino acids during central nervous system development
TL;DR: Potential therapeutic approaches may be rationally devised based on recent information about the developmental regulation of EAA receptors and their involvement in the pathogenesis of these disorders.
Journal ArticleDOI
Excitotoxity and the NMDA receptor
Steven M. Rothman,John W. Olney +1 more
TL;DR: Evidence is accumulating that the brain damage associated with anoxia, stroke, hypoglycemia, epilepsy, and perhaps neurodegenerative illnesses such as Huntington's disease may be at least partially produced by excessive activation of NMDA receptors.
Book
The genuine works of Hippocrates
TL;DR: The genuine works of Hippocrates are described in detail in "Hippocrates’s Enquiries", 2nd Ed.
Journal ArticleDOI
Predictors of epilepsy in children who have experienced febrile seizures
TL;DR: Epilepsy developed in children whose neurologic or developmental status was suspect or abnormal before any seizure and whose first seizure was complex (longer than 15 minutes, multiple or focal) epilepsy developed at a rate 18 times higher than in children with no febrile seizures.