Fertility preservation in adolescent males: experience over 22 years at Rouen University Hospital
S. Menon,N. Rives,N. Mousset-Siméon,Louis Sibert,J.P. Vannier,Sophie Mazurier,L. Massé,V. Duchesne,Bertrand Macé +8 more
TLDR
Semen cryopreservation is possible for most adolescents and, regardless of disease type, may be a means of preserving fertility prior to gonadotoxic treatment that might impair the spermatogenesis process.Abstract:
BACKGROUND Sperm banking is a suitable procedure to prevent infertility after cancer therapy in male adolescents. We evaluated the feasibility of semen preservation in 156 adolescents aged between 13 and 20 years and then we assessed fertility outcome after treatment. METHODS Age, urogenital history, indications for cryopreservation, histological diagnosis and semen parameters were recorded. Fertility status after treatment was assessed by a questionnaire addressed to those patients who had utilized sperm storage. Post-treatment semen analysis was performed for 22 patients. RESULTS Cryopreservation was possible in 88.5% of cases. Azoospermia was detected in 2.6% of the patients at the time of diagnosis. Malignant disease accounted for 84% of our male adolescents. In this type of disease, semen parameters were significantly altered only among patients with metastatic malignant bone tumour. After treatment, nine patients presented azoospermia, five patients achieved pregnancy spontaneously, two achieved it after assisted reproductive technique using fresh ejaculated spermatozoa and one following sperm donation. Three failed with cryopreserved sperm. CONCLUSIONS Semen cryopreservation is possible for most adolescents and, regardless of disease type, may be a means of preserving fertility prior to gonadotoxic treatment that might impair the spermatogenesis process.read more
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A European perspective on testicular tissue cryopreservation for fertility preservation in prepubertal and adolescent boys
Helen M. Picton,Christine Wyns,Christine Wyns,Richard A. Anderson,Ellen Goossens,Kirsi Jahnukainen,Kirsi Jahnukainen,Sabine Kliesch,Rod T. Mitchell,Guido Pennings,Natalie Rives,Herman Tournaye,Ans M.M. van Pelt,Ursula Eichenlaub-Ritter,Stefan Schlatt +14 more
TL;DR: An algorithm for the cryopreservation of sperm and testicular tissue is proposed for prepubertal boys and adolescent males at high risk of fertility loss and after consideration of the relevant ethical and legal challenges.
Journal ArticleDOI
Testicular function and fertility preservation in male cancer patients.
TL;DR: This review aims to present an overview of the current state of knowledge in mechanisms how human spermatogonia proliferate and differentiate and how cancer therapy affects germ cells, what are the options for fertility preservation andWhat are the clinical risks and limitations related to such procedures.
Journal ArticleDOI
Fertility preservation during cancer treatment: clinical guidelines
TL;DR: The current status of fertility preservation methods when infertility risks are related to surgical oncologic treatments, radiation therapy, or chemotherapy is discussed.
Journal ArticleDOI
Fertile offspring derived from mouse spermatogonial stem cells cryopreserved for more than 14 years
Xin Wu,Shaun M. Goodyear,Lara K. Abramowitz,Marisa S. Bartolomei,John W. Tobias,Mary R. Avarbock,Ralph L. Brinster +6 more
TL;DR: It is demonstrated that long-term cryopreservation of testis cells from mouse, rat, rabbit and baboon safeguards SSC viability, and that these cells can colonize the seminiferous tubules of recipient testes and provide a platform for fertility preservation in prepubertal boys undergoing gonadotoxic treatments.
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Sperm cryopreservation in adolescents and young adults with cancer: results of the French national sperm banking network (CECOS).
Myriam Daudin,Nathalie Rives,Marie Walschaerts,Véronique Drouineaud,Ethel Szerman,Isabelle Koscinski,Florence Eustache,Jacqueline Saïas-Magnan,Aline Papaxanthos-Roche,Rosalie Cabry-Goubet,Florence Brugnon,Dominique Le Lannou,Claire Barthélémy,Jean-Marc Rigot,Thomas Fréour,Isabelle Berthaut,Sandrine Giscard d'Estaing,Françoise Touati,Marie-Claude Mélin-Blocquaux,Oxana Blagosklonov,Claire Thomas,Mohamed Benhamed,Françoise Schmitt,Jean-Marie Kunstmann,Patrick Thonneau,Louis Bujan +25 more
TL;DR: The results emphasize the need for decisive changes in public health policy to facilitate the access to reproductive health-care for young cancer patients.
References
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Oncologists’ Attitudes and Practices Regarding Banking Sperm Before Cancer Treatment
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Ashok Agarwal,Pavithra Ranganathan,Namita Kattal,Fabio F. Pasqualotto,Jorge Hallak,Saba Khayal,Edward J. Mascha +6 more
TL;DR: The findings emphasize the need for physicians to discuss the issue of semen cryopreservation with all men of reproductive age who have cancer before antineoplastic therapy is started.
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Sperm Banking for Adolescent and Young Adult Cancer Patients: Sperm Quality, Patient, and Parent Perspectives
Jill P. Ginsberg,Sue Ogle,Lisa Tuchman,Claire A. Carlson,Maureen Reilly,Wendy L. Hobbie,Mary T. Rourke,Huaqing Zhao,Anna T. Meadows +8 more
TL;DR: It is aimed to evaluate feasibility of offering newly diagnosed patients the opportunity to bank sperm and to determine the beliefs and decision‐making processes of patients and their parents who considered sperm banking.