Film-Spotting chiral miniPEG-γPNA array for BRCA1 gene mutation detection.
Bo Dong,Kaixuan Nie,Huanhuan Shi,Lemeng Chao,Mingyang Ma,Fengxiao Gao,Bo Liang,Wei Chen,Mengqiu Long,Zhengchun Liu +9 more
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TLDR
This work provides an effective avenue for the diagnosis of breast cancer biomarker and expands the application of miniPEG-γPNA in the field of biochip.About:
This article is published in Biosensors and Bioelectronics.The article was published on 2019-07-01 and is currently open access. It has received 11 citations till now. The article focuses on the topics: Biochip & Peptide nucleic acid.read more
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Numerical investigation of the secondary flow effect of lateral structure of micromixing channel on laminar flow
TL;DR: In this article, a numerical investigation of secondary flow effect generated by lateral structure on laminar flows is presented, where the semicircular lateral structure was respectively applied to T-shape, Zig-zag and Spit and Recombine micromixers.
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Mixing enhancement via a serpentine micromixer for real-time activation of carboxyl
Huanhuan Shi,Huanhuan Shi,Kaixuan Nie,Bo Dong,Lemeng Chao,Fengxiao Gao,Mingyang Ma,Mengqiu Long,Zhengchun Liu +8 more
TL;DR: In this paper, a serpentine mixing channel was proposed for real-time amide condensation reaction in microfluidic mixing devices, where the high specific surface area of microchannel enables traditional chemical reactions to be accomplished efficiently and quickly using only trace amounts of reagents in real time.
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Multifunctional Delivery Systems for Peptide Nucleic Acids.
TL;DR: A review of the available carriers for peptide nucleic acids (PNAs)-oligonucleotide analogs with a polyamide backbone-with a particular emphasis on newly developed multi-component and multifunctional vehicles which boosted PNA research in recent years is presented in this article.
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Walking through the wonder years of artificial DNA: peptide nucleic acid.
TL;DR: A review article summarizes few of the structural modifications that are performed with PNA, methods used to improve their cellular uptake and shedding light on the applications of PNA in various prospects in biological sciences.
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Perspectives on conformationally constrained peptide nucleic acid (PNA): insights into the structural design, properties and applications
TL;DR: This review focuses on attempts towards the rational design of new generation PNAs with superior performance by introducing conformational constraints such as a ring or a chiral substituent in the PNA backbone.
References
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Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries
Freddie Bray,Jacques Ferlay,Isabelle Soerjomataram,Rebecca L. Siegel,Lindsey A. Torre,Ahmedin Jemal +5 more
TL;DR: A status report on the global burden of cancer worldwide using the GLOBOCAN 2018 estimates of cancer incidence and mortality produced by the International Agency for Research on Cancer, with a focus on geographic variability across 20 world regions.
Journal ArticleDOI
Sequence-selective recognition of DNA by strand displacement with a thymine-substituted polyamide
TL;DR: The results show that the backbone of DNA can be replaced by a polyamide, with the resulting oligomer retaining base-specific hybridization.
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Solid phase peptide synthesis utilizing 9‐fluorenylmethoxycarbonyl amino acids
Gregg B. Fields,Richard L. Noble +1 more
TL;DR: The great variety of conditions under which Fmoc solid phase peptide synthesis may be carried out represents a truly "orthogonal" scheme, and thus offers many unique opportunities for bioorganic chemistry.
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PNA hybridizes to complementary oligonucleotides obeying the Watson–Crick hydrogen-bonding rules
Michael Egholm,Ole Buchardt,Leif Christensen,Carsten Behrens,Susan M. Freier,David A. Driver,Rolf H. Berg,Seog K. Kim,Bengt Nordén,Peter E. Nielsen +9 more
TL;DR: It is reported here that PNA containing all four natural nucleobases hybridizes to complementary oligonucleotides obeying the WatsonCrick base-pairing rules, and thus is a true DNA mimic in terms of base- Pair recognition.
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Cancer Incidence in BRCA1 Mutation Carriers
TL;DR: In carriers of BRCA1 mutations, the overall increased risk of cancer at sites other than breast and ovary is small and is observed in women but generally not in men.